Details of Disease | DrugMAP

General Information of Disease (ID: DIS2PJJM)

Disease Name	Plasma cell neoplasm
Synonyms	plasma cell disorder; plasma cell tumour; plasma cell neoplasm; plasma cell dyscrasia; plasmacytic tumor; plasmacytic tumour; plasmacytic neoplasm; plasma cell tumor; plasma cell tumor, malignant
Definition	A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance.\|See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/39
Disease Hierarchy	DISTBY9Z: Tumour DISKAXO0: Neoplasm of mature B-cells DIS2PJJM: Plasma cell neoplasm
Disease Identifiers	MONDO ID MONDO_0004959 MESH ID D054219 UMLS CUI C1959632 MedGen ID 368758 Orphanet ID 98282 SNOMED CT ID 127580003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PTPRC	TTUS45N	moderate	Genetic Variation	[1]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GATA1	OTX1R7O1	Disputed	Altered Expression	[2]
BCL10	OT47MCLI	moderate	Biomarker	[3]
BHLHA15	OTY7IER8	Strong	Altered Expression	[4]
MBD1	OTD19VO6	Strong	Genetic Variation	[5]
MYOM2	OTD2UOXW	Strong	Biomarker	[6]
PCM1	OTFM133C	Strong	Genetic Variation	[5]
PIGA	OT51UWUR	Strong	Genetic Variation	[7]
LDLRAP1	OT6QTX7R	Definitive	Biomarker	[8]
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⏷ Show the Full List of 8 DOT(s)

References

1	Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms.Leuk Lymphoma. 2018 Aug;59(8):1913-1919. doi: 10.1080/10428194.2017.1410885. Epub 2017 Dec 7.
2	Difference in megakaryocyte expression of GATA-1, IL-6, and IL-8 associated with maintenance of platelet counts in patients with plasma cell neoplasm with dysmegakaryopoiesis.Exp Hematol. 2019 May;73:13-17.e2. doi: 10.1016/j.exphem.2019.02.005. Epub 2019 Feb 27.
3	ABL-MYC retroviral infection elicits bone marrow plasma cell tumors in Bcl-X(L) transgenic mice.Leuk Res. 2005 Apr;29(4):435-44. doi: 10.1016/j.leukres.2004.09.007. Epub 2004 Dec 18.
4	Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.Physiol Genomics. 2011 Feb 11;43(3):174-86. doi: 10.1152/physiolgenomics.00084.2010. Epub 2010 Nov 23.
5	Biphenotypic plasma cell myeloma: two cases of plasma cell neoplasm with a coexpression of kappa and lambda light chains.Int J Clin Exp Pathol. 2015 Jul 1;8(7):8536-44. eCollection 2015.
6	POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.Am J Hematol. 2019 Jul;94(7):812-827. doi: 10.1002/ajh.25495. Epub 2019 May 23.
7	A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene.Mutat Res. 2010 Apr 1;686(1-2):1-8. doi: 10.1016/j.mrfmmm.2009.11.012. Epub 2010 Jan 8.
8	Heterotransplantation of human multiple myeloma cell lines in severe combined immunodeficiency (SCID) mice.Anticancer Res. 1993 May-Jun;13(3):593-7.