Details of Disease

Disease Name

Rickettsiosis

infection, Rickettsia; Rickettsia infectious disease; Rickettsia disease or disorder; infections, Rickettsia; Rickettsia caused disease or disorder; Rickettsiosis; Rickettsial infectious disease; Rickettsiae disease; Rickettsial disease; Rickettsia infection; Rickettsial infectious disorder

Definition

A group of infectious diseases that is caused by Rickettsia.|We classify this using the NCBI Taxon for Rickettsiales to include ehlrichosis and scrub typhus

Disease Hierarchy

DIS5QJ9S: Bacterial infection

DISEM33Q: Infectious disease

DIS4GUSE: Rickettsiosis

Disease Identifiers

MONDO ID

MONDO_0006956

MESH ID

D012282

UMLS CUI

C0035585

MedGen ID

20584

Orphanet ID

102021

SNOMED CT ID

37246009

General Information of Disease (ID: DIS4GUSE)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chloramphenicol	DMFXEWT	Approved	Small molecular drug	[1]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[2]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CS	TTZA6B3	Strong	Genetic Variation	[4]
RAPGEF3	TTOE7I0	Strong	Biomarker	[5]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CFHR5	OT7BMOYE	Strong	Biomarker	[6]
SLC2A4RG	OTW3LX8D	Strong	Biomarker	[7]
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References

1	Chloramphenicol FDA Label
2	Doxycycline FDA Label
3	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
4	Identification of Rickettsial Infections (Rickettsia sp. TH2014) in Ctenocephalides orientis Fleas (Siphonaptera: Pulicidae).J Med Entomol. 2019 Feb 25;56(2):526-532. doi: 10.1093/jme/tjy169.
5	Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19615-20. doi: 10.1073/pnas.1314400110. Epub 2013 Nov 11.
6	Does complement Factor H-Related protein 5 Nephropathy (Troodos Nephropathy) protect from rickettsial infections?.Med Hypotheses. 2017 Jan;98:76-80. doi: 10.1016/j.mehy.2016.11.018. Epub 2016 Nov 27.
7	Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion.PLoS Pathog. 2015 Aug 20;11(8):e1005115. doi: 10.1371/journal.ppat.1005115. eCollection 2015 Aug.