Details of Disease

General Information of Disease (ID: DIS4IIDZ)

• Disease Name: Obstructive lung disease
• Synonyms: respiratory airway obstruction
• Disease Class: CA22: Chronic obstructive pulmonary disease
• Definition: Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent.
• Disease Hierarchy:
  DIS1LT8E: Lung disease
  DIS4IIDZ: Obstructive lung disease
• ICD Code:
  ICD-11: ICD-11: CA22.Z
  Expand ICD-11: 'CA22.Z
  Expand ICD-9: 4.90E+17
• Disease Identifiers:
  MONDO ID: MONDO_0002267
  MESH ID: D000402
  UMLS CUI: C0001883
  MedGen ID: 1387
  HPO ID: HP:0006536
  SNOMED CT ID: 79688008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ipratropium	DMFQ320	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SERPING1	TTVQ6R9	moderate	Biomarker	[2]
ADORA1	TTK25J1	Strong	Altered Expression	[3]
CCR8	TTE836A	Strong	Altered Expression	[4]
CHRNA1	TT54JVQ	Strong	Genetic Variation	[5]
F12	TTRJSMV	Strong	Genetic Variation	[6]
PLAT	TTXAGYU	Strong	Therapeutic	[7]
PTGFR	TTT2ZAR	Strong	Biomarker	[8]
SLC26A9	TTKRVU0	Strong	Biomarker	[9]
TFPI	TT068JH	Strong	Therapeutic	[10]
TSLP	TTHMW3T	Definitive	Biomarker	[11]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ATP12A	DT5NLZA	Strong	Biomarker	[12]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
AOC2	DE8DP90	Strong	Biomarker	[13]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS3	OT2U6VF5	Strong	Biomarker	[14]
ALKBH1	OTADGU5D	Strong	Genetic Variation	[15]
CA10	OTC3N1F6	Strong	Genetic Variation	[16]
CALML3	OTM8DNQU	Strong	Biomarker	[17]
COTL1	OT6YCNLF	Strong	Biomarker	[17]
CSRP3	OTECBJMV	Strong	Biomarker	[17]
DPH1	OT0QU3JY	Strong	Genetic Variation	[18]
FAM13A	OTZ6GN0Q	Strong	Genetic Variation	[19]
FEV	OTYEC4IR	Strong	Genetic Variation	[20]
KCNMB1	OTO4KNJ4	Strong	Genetic Variation	[21]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 325).
• [2] Therapeutic management of hereditary angioedema due to C1 inhibitor deficiency.Expert Rev Clin Immunol. 2013 May;9(5):477-88. doi: 10.1586/eci.13.22.
• [3] RASONs: a novel antisense oligonucleotide therapeutic approach for asthma. Expert Opin Biol Ther. 2001 Nov;1(6):979-83.
• [4] Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.J Immunol. 2005 Jun 15;174(12):8183-90. doi: 10.4049/jimmunol.174.12.8183.
• [5] Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.Respir Res. 2011 Dec 17;12(1):158. doi: 10.1186/1465-9921-12-158.
• [6] Treatment for hereditary angioedema with normal C1-INH and specific mutations in the F12 gene (HAE-FXII).Allergy. 2017 Feb;72(2):320-324. doi: 10.1111/all.13076. Epub 2016 Dec 1.
• [7] Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation.Toxicol Sci. 2015 Jan;143(1):178-84. doi: 10.1093/toxsci/kfu225. Epub 2014 Oct 20.
• [8] [Pharmacology of acebutolol in animals].Nouv Presse Med. 1975 Dec 31;4(46 Suppl):3217-21.
• [9] SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.J Clin Invest. 2012 Oct;122(10):3629-34. doi: 10.1172/JCI60429. Epub 2012 Sep 4.
• [10] Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation.Toxicol Appl Pharmacol. 2013 Oct 1;272(1):86-95. doi: 10.1016/j.taap.2013.05.020. Epub 2013 May 30.
• [11] Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa.J Immunol. 2018 Oct 15;201(8):2221-2231. doi: 10.4049/jimmunol.1800709. Epub 2018 Sep 5.
• [12] Increased expression of ATP12A proton pump in cystic fibrosis airways.JCI Insight. 2018 Oct 18;3(20):e123616. doi: 10.1172/jci.insight.123616.
• [13] Predictors of reversible airway obstruction with omalizumab in severe asthma: a real-life study.Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619841274. doi: 10.1177/1753466619841274.
• [14] An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndrome.PLoS Genet. 2019 May 16;15(5):e1008102. doi: 10.1371/journal.pgen.1008102. eCollection 2019 May.
• [15] Genetic-environmental interactions in chronic airways obstruction.Int J Epidemiol. 1986 Mar;15(1):65-72. doi: 10.1093/ije/15.1.65.
• [16] Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma.Immunogenetics. 2014 Mar;66(3):143-51. doi: 10.1007/s00251-013-0755-0. Epub 2014 Jan 10.
• [17] An algorithm for predicting Robin sequence from fetal MRI.Prenat Diagn. 2018 Apr;38(5):357-364. doi: 10.1002/pd.5239. Epub 2018 Mar 13.
• [18] Novel compound heterozygous DPH1 mutations in a patient with the unique clinical features of airway obstruction and external genital abnormalities. J Hum Genet. 2018 Apr;63(4):529-532. doi: 10.1038/s10038-017-0399-2. Epub 2018 Jan 23.
• [19] Genome-wide association study on the FEV(1)/FVC ratio in never-smokers identifies HHIP and FAM13A.J Allergy Clin Immunol. 2017 Feb;139(2):533-540. doi: 10.1016/j.jaci.2016.06.062. Epub 2016 Sep 6.
• [20] Dietary factors and lung function in the general population: wine and resveratrol intake.Eur Respir J. 2012 Feb;39(2):385-91. doi: 10.1183/09031936.00184110. Epub 2011 Aug 18.
• [21] An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.Hum Mol Genet. 2008 Sep 1;17(17):2681-90. doi: 10.1093/hmg/ddn168. Epub 2008 Jun 4.