Details of Disease

General Information of Disease (ID: DIS7D7QV)

• Disease Name: Oropharyngeal squamous cell carcinoma
• Synonyms: squamous cell carcinoma of the oropharynx; epidermoid carcinoma of the oropharynx; oropharyngeal squamous cell carcinoma; epidermoid carcinoma of oropharynx; oropharyngeal epidermoid carcinoma; oropharyngeal throat squamous cell cancer; squamous cell carcinoma of oropharynx
• Disease Class: 2B6A: Oropharyngeal cancer
• Definition: A squamous cell carcinoma that involves the oropharynx.
• Disease Hierarchy:
  DISQVIFL: Squamous cell carcinoma
  DIS7K3AI: Oropharyngeal carcinoma
  DISWZMVP: Pharyngeal squamous cell carcinoma
  DIS7D7QV: Oropharyngeal squamous cell carcinoma
• ICD Code:
  ICD-11: ICD-11: 2B6A.0
  ICD-9: ICD-9: 199
  Expand ICD-11: '2B6A.0
  Expand ICD-9: 199
• Disease Identifiers:
  MONDO ID: MONDO_0044704
  MESH ID: D000077195
  UMLS CUI: C0280313
  MedGen ID: 76094
  HPO ID: HP:0012182
  Orphanet ID: 500478
  SNOMED CT ID: 423464009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CUE-101	DMM10MW	Phase 2	Recombinant?protein	[1]
MEDI0457	DM2I30L	Phase 1/2	Vaccine	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TNFRSF10B	TTW20TU	Limited	SusceptibilityMutation	[3]
E2F2	TT5FYX0	Strong	Genetic Variation	[4]
KDM3A	TTKXS4A	Strong	Biomarker	[5]
MAGEA2	TTOZT28	Strong	Biomarker	[6]
TLR5	TTCXP8J	Strong	Altered Expression	[7]
TLR7	TTRJ1K4	Strong	Altered Expression	[7]

This Disease Is Related to 16 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ING1	OTEZBRKW	Limited	SomaticCausalMutation	[8]
CDK10	OTKP7TTR	Strong	Biomarker	[9]
CHFR	OTRAD2TT	Strong	Biomarker	[10]
CST6	OTZVHJTF	Strong	Altered Expression	[11]
CTRL	OTB6NA5O	Strong	Biomarker	[12]
DDX20	OT6G8YF3	Strong	Genetic Variation	[13]
HELLS	OTVVV668	Strong	Altered Expression	[14]
LCN1	OT8BWXTV	Strong	Biomarker	[15]
MYBBP1A	OTIVEMIU	Strong	Biomarker	[16]
MYOF	OTRFC3IJ	Strong	Altered Expression	[17]
NIPBL	OTF6OOLU	Strong	Biomarker	[18]
PEG3	OTHQW98S	Strong	Biomarker	[19]
RAB25	OTW0W6NP	Strong	Altered Expression	[20]
RAD18	OTQ9PLNT	Strong	Biomarker	[9]
RAP1GAP	OTC31ONQ	Strong	Biomarker	[21]
SMR3A	OT6NAJJI	Strong	Altered Expression	[22]

References

• [1] ClinicalTrials.gov (NCT04852328) Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma. U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT04001413) Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients. U.S. National Institutes of Health.
• [3] Causes of death in a cohort of 260 plutonium workers.Health Phys. 1998 Sep;75(3):236-40. doi: 10.1097/00004032-199809000-00001.
• [4] E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx.Mol Carcinog. 2017 Apr;56(4):1335-1343. doi: 10.1002/mc.22595. Epub 2017 Jan 2.
• [5] JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma.PLoS One. 2018 Mar 28;13(3):e0194884. doi: 10.1371/journal.pone.0194884. eCollection 2018.
• [6] Lymphatic mapping with SPECT-CT for evaluation of contralateral drainage in lateralized oropharyngeal cancers using an awake injection technique.Head Neck. 2020 Mar;42(3):385-393. doi: 10.1002/hed.26011. Epub 2019 Nov 28.
• [7] TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence.Acta Otolaryngol. 2019 Feb;139(2):206-210. doi: 10.1080/00016489.2018.1552014. Epub 2019 Feb 22.
• [8] Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.Cancer Res. 2000 Jun 15;60(12):3143-6.
• [9] Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection.Medicine (Baltimore). 2015 Dec;94(50):e2187. doi: 10.1097/MD.0000000000002187.
• [10] HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation.Cancer Med. 2014 Oct;3(5):1185-96. doi: 10.1002/cam4.313. Epub 2014 Jul 26.
• [11] Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis.Oral Oncol. 2003 Sep;39(6):559-68. doi: 10.1016/s1368-8375(03)00038-1.
• [12] Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma.Br J Cancer. 2018 Jul;119(1):89-95. doi: 10.1038/s41416-018-0143-5. Epub 2018 Jun 22.
• [13] Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.Oncotarget. 2016 Jun 7;7(23):35015-25. doi: 10.18632/oncotarget.9014.
• [14] Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma.Laryngoscope. 2011 Dec;121(12):2598-603. doi: 10.1002/lary.22379.
• [15] Elemental Zn and its Binding Protein Zinc-2-Glycoprotein are Elevated in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.Sci Rep. 2019 Nov 18;9(1):16965. doi: 10.1038/s41598-019-53268-1.
• [16] Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.Cancer Lett. 2015 Mar 28;358(2):191-199. doi: 10.1016/j.canlet.2014.12.042. Epub 2014 Dec 24.
• [17] High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status.Oncotarget. 2016 Apr 5;7(14):18665-77. doi: 10.18632/oncotarget.7625.
• [18] Extracellular vesicle microRNA cargo is correlated with HPV status in oropharyngeal carcinoma.J Oral Pathol Med. 2018 Nov;47(10):954-963. doi: 10.1111/jop.12781. Epub 2018 Oct 10.
• [19] Hypermethylation of a cluster of Krppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma.Am J Pathol. 2011 May;178(5):1965-74. doi: 10.1016/j.ajpath.2011.01.049.
• [20] RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.Epigenetics. 2016 Sep;11(9):653-663. doi: 10.1080/15592294.2016.1205176. Epub 2016 Jul 5.
• [21] Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma.Am J Pathol. 2006 Feb;168(2):585-96. doi: 10.2353/ajpath.2006.050132.
• [22] Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells.J Exp Clin Cancer Res. 2017 Feb 6;36(1):25. doi: 10.1186/s13046-017-0496-2.