Details of Disease

General Information of Disease (ID: DISAP982)

• Disease Name: Abscess
• Synonyms: abscess (disease)
• Definition: An inflammatory process characterized by the accumulation of pus within a newly formed tissue cavity which is the result of a bacterial, fungal, or parasitic infection or the presence of a foreign body.
• Disease Hierarchy:
  DISEM33Q: Infectious disease
  DISAP982: Abscess
• Disease Identifiers:
  MONDO ID: MONDO_0005227
  MESH ID: D000038
  UMLS CUI: C0000833
  MedGen ID: 1684
  HPO ID: HP:0025615
  SNOMED CT ID: 128477000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Metronidazole	DMTIVEN	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FKBP10	TT4P8O2	Strong	Biomarker	[2]
FKBP1A	TTMW94E	Strong	Biomarker	[2]
FKBP7	TTO1ENI	Strong	Biomarker	[2]
GALNS	TTT9YPO	Strong	Biomarker	[3]
LTB4R	TTN53ZF	Strong	Biomarker	[4]
NUCB1	TT6A5ZL	Strong	Altered Expression	[5]
TIRAP	TTKU0LS	Strong	Genetic Variation	[6]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC9A6	DTN0JXW	Strong	Biomarker	[7]

This Disease Is Related to 24 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PDCD10	OTCHJTSF	Limited	Genetic Variation	[8]
AZU1	OTHXU264	Strong	Biomarker	[9]
BET1	OTGX2557	Strong	Biomarker	[10]
CEACAM8	OTLL9WWO	Strong	Biomarker	[11]
FKBP1B	OT8CMPB2	Strong	Biomarker	[2]
FKBP2	OTHBZHX0	Strong	Biomarker	[2]
FKBP3	OT7ETKPE	Strong	Biomarker	[2]
FKBP9	OTGRFVKZ	Strong	Biomarker	[2]
HDLBP	OTKDEEYX	Strong	Biomarker	[9]
HEBP1	OTR9MPDX	Strong	Biomarker	[9]
MAPK8IP2	OTDUHLN0	Strong	Biomarker	[12]
NARS1	OTFS4J1W	Strong	Biomarker	[13]
NKTR	OTIADJNW	Strong	Biomarker	[2]
PAGR1	OTXR5PQ8	Strong	Biomarker	[3]
PPIL1	OTS5S837	Strong	Biomarker	[2]
PPIL2	OTL9Y4IO	Strong	Biomarker	[2]
PPIL3	OT0GPU73	Strong	Biomarker	[2]
PPIL4	OTFTLFJS	Strong	Biomarker	[2]
PPIL6	OTOZQMQE	Strong	Biomarker	[2]
SCO1	OTC45UGB	Strong	Biomarker	[14]
SLBP	OTVYYQRT	Strong	Biomarker	[9]
SPNS1	OTSJ3BJ2	Strong	Biomarker	[13]
STAM2	OT9OBWPH	Strong	Biomarker	[9]
PSTPIP1	OT4PGEAB	Definitive	Biomarker	[15]

References

• [1] Metronidazole FDA Label
• [2] Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl cis/trans Isomerase Enzymes in Staphylococcus aureus.Toxins (Basel). 2019 Jun 16;11(6):343. doi: 10.3390/toxins11060343.
• [3] Streptococcus pyogenes infections with limited emm-type diversity in the homeless population of Brussels, 2016-2018.Int J Infect Dis. 2019 Apr;81:52-56. doi: 10.1016/j.ijid.2019.01.026. Epub 2019 Jan 23.
• [4] Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice.JCI Insight. 2018 Sep 6;3(17):e120220. doi: 10.1172/jci.insight.120220. eCollection 2018 Sep 6.
• [5] A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues.J Vis Exp. 2019 Feb 19;(144):10.3791/59055. doi: 10.3791/59055.
• [6] Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections.Eur J Clin Microbiol Infect Dis. 2020 Feb;39(2):353-360. doi: 10.1007/s10096-019-03732-7. Epub 2019 Nov 30.
• [7] A case report of hepatic abscesses with soft tissue infection caused by methicillin resistant Staphylococcus aureus in a young child.Medicine (Baltimore). 2017 Dec;96(50):e9260. doi: 10.1097/MD.0000000000009260.
• [8] First case of neutropenia and thrombocytopenia in the setting of cerebral cavernous malformation 3.Int J Hematol. 2019 Jul;110(1):95-101. doi: 10.1007/s12185-019-02626-w. Epub 2019 Mar 23.
• [9] Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis.Infect Immun. 2002 Jan;70(1):5-10. doi: 10.1128/IAI.70.1.5-10.2002.
• [10] BET 1: Is routine irrigation of a cutaneous abscess necessary?.Emerg Med J. 2018 Feb;35(2):126-127. doi: 10.1136/emermed-2017-207424.2.
• [11] Immunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma.J Oral Pathol Med. 2018 Oct;47(9):856-863. doi: 10.1111/jop.12762. Epub 2018 Jul 18.
• [12] Long-term mortality and recurrence in patients treated for colonic diverticulitis with abscess formation: a nationwide register-based cohort study.Int J Colorectal Dis. 2018 Apr;33(4):431-440. doi: 10.1007/s00384-018-2990-1. Epub 2018 Mar 6.
• [13] Apremilast for moderate hidradenitis suppurativa: Results of a randomized controlled trial.J Am Acad Dermatol. 2019 Jan;80(1):80-88. doi: 10.1016/j.jaad.2018.06.046. Epub 2018 Jul 3.
• [14] Increased frequency of HLA-DR3 and complotype SCO1 in Mexican mestizo children with amoebic abscess of the liver.Parasite Immunol. 1996 Oct;18(10):491-8. doi: 10.1046/j.1365-3024.1996.d01-16.x.
• [15] Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients.Dig Dis Sci. 2010 Jun;55(6):1681-8. doi: 10.1007/s10620-009-0929-7.