General Information of Disease (ID: DISB9ZYC)

Disease Name Lymphoblastic lymphoma
Synonyms lymphoma, lymphoblastic; precursor lymphoblastic lymphoma; precursor cell lymphoblastic lymphoma; lymphoma, lymphoblastic, malignant; lymphoblastic lymphoma
Definition A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.
Disease Hierarchy
DIS1X51P: Precursor lymphoblastic lymphoma/leukemia
DISS2Y8A: Non-hodgkin lymphoma
DISB9ZYC: Lymphoblastic lymphoma
Disease Identifiers
MONDO ID
MONDO_0000873
UMLS CUI
C0079748
MedGen ID
42541
SNOMED CT ID
1217301006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
LMO2 TTFX379 Strong Biomarker [1]
SLC5A6 TT61XTV Strong Altered Expression [2]
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This Disease Is Related to 14 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CCDC88C OTIU02BS Limited Genetic Variation [3]
AIFM2 OT57XWXO Strong Biomarker [4]
ASPG OT5E2EKR Strong Biomarker [5]
CD79A OTOJC8DV Strong Altered Expression [6]
CDT1 OTVY53VG Strong Biomarker [7]
FIP1L1 OTF91GTL Strong Biomarker [8]
LMO1 OTB59SKB Strong Biomarker [1]
MPEG1 OT7DAO0F Strong Biomarker [9]
NFE2L3 OT1MGXT0 Strong Biomarker [10]
PICALM OTQVRPMQ Strong Altered Expression [11]
RPS27 OTFXKY7P Strong Biomarker [9]
STIL OT9799VN Strong Genetic Variation [12]
TLX1 OTVN0MNW Strong Biomarker [13]
FADD OTV7GFHH Definitive Biomarker [14]
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⏷ Show the Full List of 14 DOT(s)

References

1 T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes.Oncogene. 1992 Dec;7(12):2389-97.
2 Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human Jurkat lymphoblastoma cells.J Nutr. 2009 Jan;139(1):163-6. doi: 10.3945/jn.108.091967. Epub 2008 Dec 3.
3 Sustained Response to Imatinib in a Pediatric Patient with Concurrent Myeloproliferative Disease and Lymphoblastic Lymphoma Associated with a CCDC88C-PDGFRB Fusion Gene.Acta Haematol. 2019;141(2):119-127. doi: 10.1159/000495687. Epub 2019 Feb 6.
4 The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma.Int J Oncol. 2017 Jul;51(1):316-326. doi: 10.3892/ijo.2017.4006. Epub 2017 May 17.
5 Feasibility and safety of delivering full-dose anticoagulation therapy in children treated according to Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium therapy protocols.Pediatr Blood Cancer. 2019 Feb;66(2):e27483. doi: 10.1002/pbc.27483. Epub 2018 Oct 25.
6 Gene rearrangements in T-cell lymphoblastic lymphoma.J Pathol. 1999 Jul;188(3):267-70. doi: 10.1002/(SICI)1096-9896(199907)188:3<267::AID-PATH357>3.0.CO;2-N.
7 Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.Oncogene. 2005 Dec 8;24(55):8176-86. doi: 10.1038/sj.onc.1208881.
8 Synchronous FIP1L1-PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma: a bilineal clonal malignancy.Eur J Haematol. 2008 Jan;80(1):81-6. doi: 10.1111/j.1600-0609.2007.00973.x. Epub 2007 Nov 19.
9 Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13427-32. doi: 10.1073/pnas.1400892111. Epub 2014 Sep 2.
10 Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma.Blood. 2011 Feb 10;117(6):2005-8. doi: 10.1182/blood-2010-02-271460. Epub 2010 Dec 8.
11 Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens.Cancer Genet. 2020 Jan;240:40-44. doi: 10.1016/j.cancergen.2019.11.002. Epub 2019 Nov 9.
12 An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.EMBO J. 1997 May 1;16(9):2408-19. doi: 10.1093/emboj/16.9.2408.
13 A novel translocation, t(9;17)(q34;q23), in aggressive childhood lymphoblastic lymphoma.Leukemia. 1988 Nov;2(11):745-8.
14 S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma.Carcinogenesis. 2019 Oct 16;40(10):1260-1268. doi: 10.1093/carcin/bgz041.