Details of Disease

General Information of Disease (ID: DISBPYCZ)

• Disease Name: Spondyloarthropathy
• Synonyms: spondylarthropathy; spondylarthrosis; spondarthropathy; spondyloarthritis; seronegative spondyloarthropathy
• Definition: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.
• Disease Hierarchy:
  DISVEERK: Arthropathy
  DISAEGPH: Immune system disorder
  DISBPYCZ: Spondyloarthropathy
• Disease Identifiers:
  MONDO ID: MONDO_0005095
  MESH ID: D025242
  UMLS CUI: C0949691
  MedGen ID: 181888
  SNOMED CT ID: 372109003

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL23A	TTC1GLB	Limited	Biomarker	[1]
ENPP1	TTZTIWS	moderate	Biomarker	[2]
ERAP1	TT60XFL	moderate	Genetic Variation	[3]
GEM	TTAZF9M	moderate	Biomarker	[4]
SLC14A1	TTWVJU1	Definitive	Biomarker	[5]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACAN	OTUOCW8K	moderate	Biomarker	[6]
KIR3DL1	OTPOSXFX	moderate	Biomarker	[4]
ALDOA	OTWRFTIB	Strong	Altered Expression	[7]
CD5L	OTPY4WQR	Strong	Biomarker	[8]
CDKAL1	OTA0SGNE	Definitive	Genetic Variation	[9]
HSPA1L	OTC2V1K6	Definitive	Genetic Variation	[10]
IL27RA	OTSQBAKI	Definitive	Biomarker	[11]
KREMEN1	OTGJFSAC	Definitive	Biomarker	[12]
MARCO	OT0NW2Q0	Definitive	Altered Expression	[13]
MRAP	OTLBWM7X	Definitive	Biomarker	[14]
PCBD2	OTXV0ZD0	Definitive	Biomarker	[15]
RIOX1	OTN41QXP	Definitive	Biomarker	[16]

References

• [1] IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota.Ann Rheum Dis. 2019 Apr;78(4):494-503. doi: 10.1136/annrheumdis-2018-214381. Epub 2019 Jan 30.
• [2] Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy).Eur J Histochem. 1997;41(3):191-202.
• [3] 'MHC-I-opathy'-unified concept for spondyloarthritis and Behet disease.Nat Rev Rheumatol. 2015 Dec;11(12):731-40. doi: 10.1038/nrrheum.2015.147. Epub 2015 Nov 3.
• [4] Killer immunoglobulin-like receptor genes in uveitis.Ocul Immunol Inflamm. 2011 Jun;19(3):192-201. doi: 10.3109/09273948.2010.538798.
• [5] Three-dimensional ultrashort echo time (3D UTE) MRI of Achilles tendon at 4.7T MRI with comparison to conventional sequences in an experimental murine model of spondyloarthropathy.J Magn Reson Imaging. 2019 Jul;50(1):127-135. doi: 10.1002/jmri.26569. Epub 2018 Dec 21.
• [6] Experimental spondyloarthropathies: animal models of ankylosing spondylitis.Curr Rheumatol Rep. 2006 Aug;8(4):267-74. doi: 10.1007/s11926-006-0007-5.
• [7] Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry.Proteomics. 2005 May;5(8):2247-57. doi: 10.1002/pmic.200401109.
• [8] Foot functions in ankylosing spondylitis.Clin Rheumatol. 2019 Apr;38(4):1083-1088. doi: 10.1007/s10067-018-4386-6. Epub 2018 Dec 3.
• [9] Different Contributions of CDKAL1, KIF21B, and LRRK2/MUC19 Polymorphisms to SAPHO Syndrome, Rheumatoid Arthritis, Ankylosing Spondylitis, and Seronegative Spondyloarthropathy.Genet Test Mol Biomarkers. 2017 Feb;21(2):122-126. doi: 10.1089/gtmb.2016.0112. Epub 2016 Dec 12.
• [10] Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies.Ann Rheum Dis. 2002 Jan;61(1):48-51. doi: 10.1136/ard.61.1.48.
• [11] A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
• [12] Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes.BMC Musculoskelet Disord. 2013 Dec 15;14:354. doi: 10.1186/1471-2474-14-354.
• [13] Expression of host defense scavenger receptors in spondylarthropathy.Arthritis Rheum. 2001 Apr;44(4):931-9. doi: 10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T.
• [14] HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides.Ann N Y Acad Sci. 2009 Sep;1173:570-4. doi: 10.1111/j.1749-6632.2009.04757.x.
• [15] Autoantibodies to the HLA-B27 sequence cross-react with the hypothetical peptide from the arthritis-associated Shigella plasmid.J Clin Invest. 1990 Oct;86(4):1193-203. doi: 10.1172/JCI114825.
• [16] Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the subpathway method.Mol Med Rep. 2018 Oct;18(4):3825-3833. doi: 10.3892/mmr.2018.9395. Epub 2018 Aug 17.