Details of Disease

General Information of Disease (ID: DISAEGPH)

• Disease Name: Immune system disorder
• Synonyms: immune system disease or disorder; immune dysfunction; disease or disorder of immune system; immune disorder; disease of immune system; immune system disorder; immune disease; disorder of immune system
• Definition: A disorder resulting from an abnormality in the immune system.
• Disease Hierarchy:
  DISH7H5I: Human disease
  DISAEGPH: Immune system disorder
• Disease Identifiers:
  MONDO ID: MONDO_0005046
  MESH ID: D007154
  UMLS CUI: C0021053
  MedGen ID: 5759
  SNOMED CT ID: 41266007

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 59 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADA	TTLP57V	Limited	Genetic Variation	[1]
ADORA3	TTJFY5U	Limited	Biomarker	[2]
AGRP	TT4DE1O	Limited	Biomarker	[3]
BTK	TTGM6VW	Limited	Biomarker	[4]
CDK8	TTBJR4L	Limited	Altered Expression	[5]
DPP4	TTDIGC1	Limited	Biomarker	[6]
HTT	TTIWZ0O	Limited	Biomarker	[7]
IL23R	TT6H4QR	Limited	Biomarker	[8]
LILRB2	TTHC6XU	Limited	Altered Expression	[9]
NLRC5	TTWZC78	Limited	Altered Expression	[10]
ORAI1	TTE76YK	Limited	Biomarker	[11]
OXTR	TTSCIUP	Limited	Altered Expression	[12]
PLA2R1	TTHKW7D	Limited	Altered Expression	[13]
PNP	TTMCF1Y	Limited	Biomarker	[14]
TIGIT	TTWNL74	Limited	Biomarker	[15]
TSLP	TTHMW3T	Limited	Biomarker	[16]
ADAM33	TTQICM2	moderate	Biomarker	[17]
C9orf72	TTA4SHR	moderate	Genetic Variation	[18]
CLEC12A	TT70N8V	moderate	Biomarker	[19]
CTSC	TT4H0V2	moderate	Biomarker	[20]
DCLK3	TTMYK4Z	moderate	Genetic Variation	[21]
DUSP10	TTF3RJ0	moderate	Biomarker	[22]
ETS1	TTTGPSD	moderate	Genetic Variation	[23]
FCGR1A	TTZK4I3	moderate	Altered Expression	[24]
FOXP3	TT1X3QF	moderate	Altered Expression	[5]
GP6	TTTJUVZ	moderate	Genetic Variation	[25]
HPN	TT25MVL	moderate	Biomarker	[26]
ICOSLG	TTB9Z8R	moderate	Genetic Variation	[23]
IDO2	TTALN9W	moderate	Biomarker	[27]
IL19	TT87RWS	moderate	Biomarker	[28]
IL2RB	TT9721Y	moderate	Genetic Variation	[23]
ITK	TT3C80U	moderate	Genetic Variation	[29]
KIF5A	TTCJPAH	moderate	Genetic Variation	[23]
KLRG1	TT299E6	moderate	Altered Expression	[30]
MOG	TTQAFX5	moderate	Biomarker	[31]
PPP2CA	TTHTKNY	moderate	Genetic Variation	[32]
PRCP	TTTJZ4M	moderate	Biomarker	[33]
PTPN2	TTY8PUS	moderate	Genetic Variation	[23]
RBCK1	TTIKUVC	moderate	Genetic Variation	[34]
REL	TT1ZCTH	moderate	Genetic Variation	[23]
RHBDF2	TTH1ZOP	moderate	Biomarker	[35]
SH2B3	TT36N7Z	moderate	Genetic Variation	[23]
ARG1	TT7ZQEV	Strong	Biomarker	[36]
CCR3	TTD3XFU	Strong	Genetic Variation	[23]
CCR6	TTFDB30	Strong	Genetic Variation	[37]
CD40	TT1ERKL	Strong	Genetic Variation	[23]
CNR2	TTMSFAW	Strong	Biomarker	[38]
EIF2AK4	TT9U4EP	Strong	Biomarker	[36]
ENTPD1	TTYM8DJ	Strong	Biomarker	[39]
ICOS	TTE5VP6	Strong	Genetic Variation	[23]
IL2RA	TT10Y9E	Strong	Genetic Variation	[23]
MBL2	TTMQDZ5	Strong	Biomarker	[40]
POMC	TT21AKM	Strong	Biomarker	[41]
TRPM7	TTFPVZO	Strong	Biomarker	[42]
APCS	TTB7VAT	Definitive	Biomarker	[43]
CD28	TTQ13FT	Definitive	Biomarker	[44]
CD74	TTCMYP9	Definitive	Biomarker	[45]
CRLF2	TTRMZ0N	Definitive	Biomarker	[16]
TNFSF13	TTOI1RM	Definitive	Biomarker	[46]

This Disease Is Related to 4 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Limited	Biomarker	[47]
SLC30A2	DTIAF6C	Limited	Biomarker	[48]
SLC39A4	DTEZCUM	Limited	Biomarker	[48]
SLC35A1	DTVZIRG	moderate	Biomarker	[49]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
TPMT	DEFQ8VO	Limited	Genetic Variation	[50]
ADH6	DE017IC	moderate	Biomarker	[51]
MMEL1	DEYCUQ2	moderate	Genetic Variation	[23]
PGPEP1	DEVDR46	moderate	Biomarker	[33]

This Disease Is Related to 99 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACSBG1	OTM040MW	Limited	Biomarker	[52]
ARTN	OTWIWGL6	Limited	Biomarker	[3]
CCL3L1	OTQXCYB1	Limited	Biomarker	[53]
CD81	OTQFXNAZ	Limited	Biomarker	[54]
CISH	OT8T5NYL	Limited	Biomarker	[55]
CLC	OTYMYR85	Limited	Altered Expression	[56]
FHL3	OTMPRLZ5	Limited	Genetic Variation	[57]
GIMAP4	OTEUZH06	Limited	Biomarker	[58]
GIMAP5	OTMND7IR	Limited	Biomarker	[58]
GSDMB	OTWA7P10	Limited	Biomarker	[59]
HOXC6	OTBCRAZV	Limited	Biomarker	[60]
IRF5	OT8SIIAP	Limited	Biomarker	[61]
NUDT15	OTX8SZOT	Limited	Genetic Variation	[50]
PLCG2	OTGVC9MY	Limited	Genetic Variation	[62]
PTPN4	OT6SXU5Y	Limited	Genetic Variation	[63]
RAB27A	OT9SQRWY	Limited	Genetic Variation	[64]
RAPH1	OTMQXW7S	Limited	Biomarker	[52]
SHARPIN	OTU1J2KH	Limited	Biomarker	[65]
SPACA9	OTVRFX49	Limited	Genetic Variation	[12]
SPG21	OTMKJSYS	Limited	Genetic Variation	[12]
TNFAIP8	OT1G9297	Limited	Altered Expression	[66]
TOM1	OT30QA56	Limited	Autosomal dominant	[67]
AFF3	OTR0705Z	moderate	Genetic Variation	[23]
ANKRD55	OT62KZII	moderate	Genetic Variation	[23]
ARHGAP31	OTUYTF4I	moderate	Genetic Variation	[23]
ARSD	OTAHW9M8	moderate	Biomarker	[68]
ATG5	OT4T5SMS	moderate	Genetic Variation	[23]
BACH2	OT17GS18	moderate	Genetic Variation	[23]
BAMBI	OTCEJ8W5	moderate	Biomarker	[69]
C4A	OTXMOYXU	moderate	Biomarker	[70]
CCDC88B	OTEDUI2J	moderate	Genetic Variation	[71]
CCL7	OTDIS99H	moderate	Altered Expression	[72]
CD247	OT45FGUX	moderate	Genetic Variation	[23]
CDSN	OTQW4HV6	moderate	Altered Expression	[73]
CLEC16A	OTLGV5SV	moderate	Biomarker	[74]
CRB1	OTXYUNG0	moderate	Biomarker	[75]
DDX3Y	OTKL1FNX	moderate	Biomarker	[76]
DDX6	OTKWXVDY	moderate	Genetic Variation	[23]
DENND1B	OT3VCNPE	moderate	Genetic Variation	[77]
DOCK8	OTNQLL21	moderate	Genetic Variation	[78]
EIF1AY	OTWVDOJU	moderate	Biomarker	[76]
ELMO1	OTY2ORXK	moderate	Genetic Variation	[23]
FAM107A	OTBG61YZ	moderate	Genetic Variation	[23]
FCRL3	OTIFXFWL	moderate	Biomarker	[79]
GAL3ST1	OTSFFZRD	moderate	Biomarker	[49]
GPR83	OT7A2FE8	moderate	Altered Expression	[80]
HLA-DRB4	OTNXIHQU	moderate	Biomarker	[81]
IFI16	OT4SPU0U	moderate	Genetic Variation	[23]
IGSF6	OT5TUH02	moderate	Biomarker	[82]
IL17C	OTKXIVNQ	moderate	Biomarker	[83]
ITPA	OTQ47WVR	moderate	Biomarker	[84]
KLF13	OTMIKHZ4	moderate	Biomarker	[85]
KLRB1	OTQ2959Y	moderate	Biomarker	[86]
LCE3B	OT7X6LDK	moderate	Biomarker	[87]
LCE3C	OT3RWMGH	moderate	Biomarker	[87]
LPP	OT6TU8SE	moderate	Genetic Variation	[23]
LRBA	OTOUZN9G	moderate	Biomarker	[88]
MACIR	OTPSW8Y8	moderate	Genetic Variation	[23]
MEX3C	OT8AJG1I	moderate	Biomarker	[89]
NCF4	OTX007YL	moderate	Biomarker	[90]
NUP85	OTB5ZHC8	moderate	Altered Expression	[91]
ORMDL3	OTAB7MZF	moderate	Biomarker	[92]
OSCP1	OTZ4IFGJ	moderate	Biomarker	[93]
PHF19	OTF6RUCR	moderate	Genetic Variation	[23]
PLEK	OTB73XXA	moderate	Genetic Variation	[23]
PLEKHA1	OT66PF24	moderate	Genetic Variation	[23]
PUS10	OTFFJWZX	moderate	Genetic Variation	[23]
RCAN1	OT1MVXC7	moderate	Altered Expression	[94]
RMI2	OTA0HP4S	moderate	Genetic Variation	[23]
RPL17	OTTYMPS6	moderate	Biomarker	[95]
SPRED2	OTUX685J	moderate	Genetic Variation	[23]
STAT4	OTAK3VFR	moderate	Genetic Variation	[23]
TAGAP	OTHJNNO2	moderate	Genetic Variation	[23]
TIMD4	OTGGC20G	moderate	Biomarker	[96]
TRAF1	OTTLM5RU	moderate	Genetic Variation	[23]
TREX1	OTQG7K12	moderate	Biomarker	[97]
TTC34	OT6UGMDV	moderate	Genetic Variation	[23]
TTC7A	OTDHLPQM	moderate	Genetic Variation	[98]
ARHGEF5	OTUVGFT9	Strong	Genetic Variation	[99]
ARL6IP5	OTYZ6BEQ	Strong	Biomarker	[100]
ATF5	OT03QCLM	Strong	Biomarker	[101]
CD180	OTITK5E6	Strong	Biomarker	[102]
CNBP	OTTGM9NK	Strong	Genetic Variation	[103]
FSTL1	OT6KEZUD	Strong	Biomarker	[104]
GFI1B	OTRDW8YO	Strong	Biomarker	[105]
IL36A	OTHBEL5H	Strong	Biomarker	[106]
KIF3A	OTMUBSSK	Strong	Genetic Variation	[107]
MYH10	OTXN2WXS	Strong	Biomarker	[105]
PSD3	OTTN9B9O	Strong	Biomarker	[108]
PTPN22	OTDCNTC3	Strong	Biomarker	[109]
RAB6A	OTLS86J5	Strong	Biomarker	[110]
SH2D1A	OTLU49I5	Strong	Biomarker	[111]
SLAMF8	OTATVST8	Strong	Biomarker	[112]
SNRNP40	OTSRL6QO	Strong	Altered Expression	[113]
STIM1	OT8CLQ1W	Strong	Biomarker	[114]
TIMELESS	OTD8DCBJ	Strong	Genetic Variation	[99]
TNIP1	OTRAOTEW	Strong	Biomarker	[115]
ACP1	OTJ9CKLU	Definitive	Biomarker	[116]
HAVCR1	OT184CRZ	Definitive	Biomarker	[117]

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