Details of Disease

General Information of Disease (ID: DISBY81U)

• Disease Name: Adult teratoma
• Synonyms: teratoma; teratoma of adults; adult teratoma
• Definition: A teratoma that occurs in an adult.
• Disease Hierarchy:
  DIS6ICY4: Teratoma
  DISJUCQ7: Adult germ cell tumor
  DISBY81U: Adult teratoma
• Disease Identifiers:
  MONDO ID: MONDO_0003516
  UMLS CUI: C1368898
  MedGen ID: 277966

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ifosfamide	DMCT3I8	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PSMD10	TT2H4LN	Limited	Altered Expression	[2]
DNMT3L	TT3FDAV	Strong	Altered Expression	[3]
GMNN	TT390KA	Strong	Biomarker	[4]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CHAC2	DEB4JZV	Strong	Altered Expression	[5]

This Disease Is Related to 25 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DND1	OTHLC8TA	moderate	Biomarker	[6]
ALPG	OTCIM29R	Strong	Altered Expression	[7]
ASXL3	OTNDJWEZ	Strong	Biomarker	[8]
ATN1	OTNZFLKY	Strong	Biomarker	[9]
CALD1	OTNJKJ6Q	Strong	Biomarker	[10]
CBX5	OT8VYY84	Strong	Biomarker	[11]
CREG1	OTRHJ8HK	Strong	Biomarker	[12]
DMRT1	OT5PU9U1	Strong	Genetic Variation	[13]
ELF4	OT167PR5	Strong	Biomarker	[14]
FMOD	OT9EJ5H8	Strong	Biomarker	[15]
GFI1B	OTRDW8YO	Strong	Altered Expression	[16]
GFRA1	OT3WBVYB	Strong	Genetic Variation	[17]
GPC4	OTUJ14DW	Strong	Biomarker	[18]
ITFG1	OTX0PCR3	Strong	Genetic Variation	[19]
LSM2	OTHL77NY	Strong	Genetic Variation	[20]
MESD	OT3B2H8F	Strong	Genetic Variation	[21]
METTL8	OT7E09Y4	Strong	Genetic Variation	[19]
MNX1	OTXP9FH1	Strong	Biomarker	[22]
NANOG	OTUEY1FM	Strong	Posttranslational Modification	[23]
NANOS3	OTGX9IQU	Strong	Genetic Variation	[17]
PLAA	OTZ7NJGA	Strong	Altered Expression	[7]
PRPF4	OTK0XRQN	Strong	Biomarker	[24]
TCF12	OTZVONNU	Strong	Altered Expression	[25]
TFAP2C	OTUDIW05	Strong	Altered Expression	[7]
TIPRL	OTS2FZ8O	Strong	Genetic Variation	[19]

References

• [1] Ifosfamide FDA Label
• [2] The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.BMC Cancer. 2019 Nov 19;19(1):1124. doi: 10.1186/s12885-019-6340-7.
• [3] DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.Jpn J Clin Oncol. 2016 May;46(5):475-81. doi: 10.1093/jjco/hyw012. Epub 2016 Feb 24.
• [4] Geminin Is Essential for Pluripotent Cell Viability During Teratoma Formation, but Not for Differentiated Cell Viability During Teratoma Expansion.Stem Cells Dev. 2017 Feb 15;26(4):285-302. doi: 10.1089/scd.2016.0260. Epub 2016 Nov 7.
• [5] CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.Free Radic Biol Med. 2017 Dec;113:439-451. doi: 10.1016/j.freeradbiomed.2017.10.345. Epub 2017 Oct 18.
• [6] Derivation of pluripotent stem cells from nascent undifferentiated teratoma.Dev Biol. 2019 Feb 1;446(1):43-55. doi: 10.1016/j.ydbio.2018.11.020. Epub 2018 Dec 5.
• [7] Diagnostic markers for germ cell neoplasms: from placental-like alkaline phosphatase to micro-RNAs.Folia Histochem Cytobiol. 2015;53(3):177-88. doi: 10.5603/FHC.a2015.0020. Epub 2015 Aug 26.
• [8] ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.Cancer Res. 2017 Nov 15;77(22):6267-6281. doi: 10.1158/0008-5472.CAN-17-0570. Epub 2017 Sep 21.
• [9] Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations.Front Mol Neurosci. 2019 Sep 11;12:212. doi: 10.3389/fnmol.2019.00212. eCollection 2019.
• [10] Vascular Smooth Muscle Cell Maturation Stage and Ki-67 Index are Diagnostic Biomarkers for Pathologic Grade of Ovarian Teratoma.Int J Gynecol Pathol. 2017 Nov;36(6):582-592. doi: 10.1097/PGP.0000000000000373.
• [11] Heterochromatin marks HP1, HP1 and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.Int J Androl. 2011 Aug;34(4 Pt 2):e103-13. doi: 10.1111/j.1365-2605.2010.01096.x. Epub 2010 Aug 1.
• [12] Transplantation of CREG modified embryonic stem cells improves cardiac function after myocardial infarction in mice.Biochem Biophys Res Commun. 2018 Sep 5;503(2):482-489. doi: 10.1016/j.bbrc.2018.04.160. Epub 2018 Jun 30.
• [13] Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.Nat Genet. 2010 Jul;42(7):604-7. doi: 10.1038/ng.607. Epub 2010 Jun 13.
• [14] Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation.J Biol Chem. 2016 Jan 8;291(2):752-61. doi: 10.1074/jbc.M115.659276. Epub 2015 Nov 23.
• [15] CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells.J Clin Invest. 2019 Jul 15;129(8):3236-3251. doi: 10.1172/JCI125015. eCollection 2019 Jul 15.
• [16] InVivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.Stem Cell Reports. 2017 Oct 10;9(4):1024-1033. doi: 10.1016/j.stemcr.2017.08.010. Epub 2017 Sep 21.
• [17] Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.Dev Biol. 2013 May 1;377(1):67-78. doi: 10.1016/j.ydbio.2013.02.014. Epub 2013 Mar 6.
• [18] Reducing glypican-4 in ES cells improves recovery in a rat model of Parkinson's disease by increasing the production of dopaminergic neurons and decreasing teratoma formation.J Neurosci. 2014 Jun 11;34(24):8318-23. doi: 10.1523/JNEUROSCI.2501-13.2014.
• [19] Surgical Management of Patients with Advanced Germ Cell Tumors Following Salvage Chemotherapy: Memorial Sloan Kettering Cancer Center (MSKCC) Experience.Urology. 2019 Feb;124:174-178. doi: 10.1016/j.urology.2018.09.024. Epub 2018 Oct 6.
• [20] The complete primary structure of the human snRNP E protein.Nucleic Acids Res. 1988 Nov 25;16(22):10593-605. doi: 10.1093/nar/16.22.10593.
• [21] Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).Hum Mol Genet. 2005 Jul 15;14(14):1955-63. doi: 10.1093/hmg/ddi200. Epub 2005 May 25.
• [22] Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p.Prenat Diagn. 2003 Dec 15;23(12):981-4. doi: 10.1002/pd.742.
• [23] Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.Genome Res. 2016 Nov;26(11):1490-1504. doi: 10.1101/gr.201293.115. Epub 2016 Oct 20.
• [24] Suppression of PRPF4 regulates pluripotency, proliferation, and differentiation in mouse embryonic stem cells.Cell Biochem Funct. 2019 Dec;37(8):608-617. doi: 10.1002/cbf.3437. Epub 2019 Sep 10.
• [25] Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.Stem Cell Reports. 2017 Sep 12;9(3):779-795. doi: 10.1016/j.stemcr.2017.07.011. Epub 2017 Aug 10.