Details of Disease | DrugMAP

General Information of Disease (ID: DISDR98B)

Disease Name	Digestive system neuroendocrine tumor, grade 1/2
Synonyms	GINET; malignant gastrointestinal neuroendocrine tumour; malignant gastrointestinal neuroendocrine tumor; gastrointestinal system neuroendocrine tumour; gastrointestinal system neuroendocrine tumor; gastrointestinal neuroendocrine tumours; gastrointestinal neuroendocrine tumour; gastrointestinal neuroendocrine tumors; gastrointestinal neuroendocrine tumor; gastrointestinal NET; gastroenteropancreatic neuroendocrine tumour; gastroenteropancreatic neuroendocrine tumor; gastroenteropancreatic NET; digestive system well differentiated neuroendocrine tumour; digestive system well differentiated neuroendocrine tumor; digestive system neuroendocrine tumour; digestive system neuroendocrine tumor; digestive system NET; alimentary part of gastrointestinal system neuroendocrine tumour; alimentary part of gastrointestinal system neuroendocrine tumor
Definition	A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas.
Disease Hierarchy	DISNPLOO: Neuroendocrine neoplasm DISRJKZM: Digestive system neuroendocrine neoplasm DISDR98B: Digestive system neuroendocrine tumor, grade 1/2
Disease Identifiers	MONDO ID MONDO_0000386 MESH ID C535650 UMLS CUI C2930967 MedGen ID 443945

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD86	TT53XHB	Strong	Biomarker	[1]
GATA3	TT45KOB	Strong	Biomarker	[1]
IKZF3	TTCZVFZ	Strong	Biomarker	[1]
IL2RB	TT9721Y	Strong	Biomarker	[1]
NOTCH2	TT82FVD	Strong	Biomarker	[1]
PTPRC	TTUS45N	Strong	Biomarker	[1]
RUNX3	TTKCVO7	Strong	Biomarker	[1]
SERPINA1	TTA7UJC	Strong	Biomarker	[1]
SST	TTWF7UG	Definitive	Biomarker	[2]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ORAI3	OTUP3OH3	Limited	Biomarker	[3]
ASCL1	OTI4X44G	Strong	Biomarker	[4]
CD53	OT9U5OXJ	Strong	Biomarker	[1]
CIITA	OTRJNZFO	Strong	Biomarker	[1]
EOMES	OTB9VQFA	Strong	Biomarker	[1]
GFI1	OT9HB9H8	Strong	Biomarker	[1]
IKZF1	OTCW1FKL	Strong	Biomarker	[1]
POU2F2	OTPV0J0C	Strong	Biomarker	[1]
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⏷ Show the Full List of 8 DOT(s)

References

1	A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.Nat Genet. 2018 Jul;50(7):979-989. doi: 10.1038/s41588-018-0138-4. Epub 2018 Jun 18.
2	Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis.JAMA Oncol. 2019 Apr 1;5(4):480-489. doi: 10.1001/jamaoncol.2018.6720.
3	Arachidonic acid-induced Ca(2+) entry and migration in a neuroendocrine cancer cell line.Cancer Cell Int. 2018 Mar 2;18:30. doi: 10.1186/s12935-018-0529-8. eCollection 2018.
4	Achaete-scute homolog 1 as a marker of poorly differentiated neuroendocrine carcinomas of different sites: a validation study using immunohistochemistry and quantitative real-time polymerase chain reaction on 335 cases.Hum Pathol. 2013 Jul;44(7):1391-9. doi: 10.1016/j.humpath.2012.11.013. Epub 2013 Jan 31.