Details of Disease

General Information of Disease (ID: DISF9I3O)

• Disease Name: Paralysis
• Synonyms: tetraplegia; bilateral diplegia
• Disease Class: 8B60: Motor neuron disease
• Definition: Paralysis of all four limbs.
• Disease Hierarchy:
  DISH9EST: Palsy
  DISF9I3O: Paralysis
• ICD Code:
  ICD-11: ICD-11: 8B60
  ICD-10: ICD-10: G12.2
• Disease Identifiers:
  MONDO ID: MONDO_0001590
  MESH ID: D011782
  UMLS CUI: C0034372
  MedGen ID: 19617
  HPO ID: HP:0002445
  SNOMED CT ID: 11538006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ORG-9273	DMW1FT0	Discontinued in Phase 2	Small molecular drug	[1]
ANQ-9040	DMRQFIE	Discontinued in Phase 1	NA	[2]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ORG-9453	DM5X2RV	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC6A3	TTVBI8W	Strong	CausalMutation	[4]
ALDH3A2	TTB6UM0	Definitive	Altered Expression	[5]

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PMP22	OTXWYWCZ	Strong	Biomarker	[6]
TBCD	OTS4JKNQ	Strong	Biomarker	[7]
CENPJ	OTZCQZN5	Definitive	Biomarker	[8]
FXYD1	OTNKT6GP	Definitive	Biomarker	[9]
LDB1	OT20EAPR	Definitive	Genetic Variation	[10]
RANBP2	OTFG5CVF	Definitive	Genetic Variation	[11]
RPE	OT0XT3JU	Definitive	Biomarker	[12]

References

• [1] Dose-response relation, neuromuscular blocking action, intubation conditions, and cardiovascular effects of Org 9273, a new neuromuscular blocking agent. Anesth Analg. 1991 Jun;72(6):811-6.
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003547)
• [3] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [4] Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012;7(1):e28936. doi: 10.1371/journal.pone.0028936. Epub 2012 Jan 17.
• [5] Adeno-associated virus vectors are able to restore fatty aldehyde dehydrogenase-deficiency. Implications for gene therapy in Sjogren-Larsson syndrome.Arch Dermatol Res. 2005 Jun;296(12):568-72. doi: 10.1007/s00403-005-0556-x. Epub 2005 Apr 15.
• [6] Hereditary neuropathy with liability to pressure palsies emerging during vincristine treatment.Neurology. 2002 Nov 12;59(9):1470-1. doi: 10.1212/01.wnl.0000032505.45389.94.
• [7] Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy. Am J Hum Genet. 2016 Oct 6;99(4):962-973. doi: 10.1016/j.ajhg.2016.08.003. Epub 2016 Sep 22.
• [8] Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.Thorax. 2019 Mar;74(3):282-290. doi: 10.1136/thoraxjnl-2018-212319. Epub 2018 Dec 11.
• [9] Periodic limb movements in tetraplegia.J Spinal Cord Med. 2018 May;41(3):318-325. doi: 10.1080/10790268.2017.1320874. Epub 2017 May 2.
• [10] The graded redefined assessment of strength sensibility and prehension version 2 (GV2): Psychometric properties.J Spinal Cord Med. 2019 Oct;42(sup1):149-157. doi: 10.1080/10790268.2019.1616950.
• [11] Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis.J Neurol. 2013 Jun;260(6):1545-53. doi: 10.1007/s00415-012-6825-7. Epub 2013 Jan 18.
• [12] Modeling Perceived Exertion during Graded Arm Cycling Exercise in Spinal Cord Injury.Med Sci Sports Exerc. 2017 Jun;49(6):1190-1196. doi: 10.1249/MSS.0000000000001203.