Details of Disease

General Information of Disease (ID: DISFPH28)

• Disease Name: Alcohol withdrawal delirium
• Synonyms: alcohol withdrawal associated autonomic hyperactivity; delirium Tremens, alcohol withdrawal induced; alcohol withdrawal-induced delirium Tremens; hallucinosis, alcohol withdrawal; delirium, alcohol withdrawal; delirium Tremens; autonomic hyperactivity, alcohol withdrawal associated; alcohol withdrawal induced delirium Tremens; alcohol withdrawal hallucinosis
• Definition: An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include confusion; delusions; vivid hallucinations; tremor; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)
• Disease Hierarchy:
  DIS3K4KK: Alcohol-related disorders
  DIS7INCX: Alcohol withdrawal
  DISDPDYM: Alcohol-induced mental disorder
  DISFPH28: Alcohol withdrawal delirium
• Disease Identifiers:
  MONDO ID: MONDO_0006642
  MESH ID: D000430
  UMLS CUI: C0001957
  MedGen ID: 1398
  SNOMED CT ID: 8635005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chlordiazepoxide	DMTN5XI	Approved	Small molecular drug	[1]
Diazepam	DM08E9O	Approved	Small molecular drug	[2]
Oxazepam	DMXNZM4	Approved	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CCKAR	TTCG0AL	moderate	Genetic Variation	[4]
DRD3	TT4C8EA	Strong	Genetic Variation	[5]
GRIK3	TTNP6O2	Strong	Genetic Variation	[6]
GRM7	TT0I76D	Strong	Genetic Variation	[7]
SLC6A3	TTVBI8W	Strong	Genetic Variation	[8]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLOCK	OTNEOJY7	Strong	Biomarker	[9]

References

• [1] Chlordiazepoxide FDA Label
• [2] Diazepam FDA Label
• [3] Oxazepam FDA Label
• [4] Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism.Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):2S-5S. doi: 10.1097/01.ALC.0000026826.96191.FB.
• [5] The genetics of deliria.Int Rev Psychiatry. 2009 Feb;21(1):20-9. doi: 10.1080/09540260802675510.
• [6] Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics.Pharmacogenomics J. 2006 Jan-Feb;6(1):34-41. doi: 10.1038/sj.tpj.6500343.
• [7] No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.Alcohol Alcohol. 2002 Mar-Apr;37(2):174-8. doi: 10.1093/alcalc/37.2.174.
• [8] The association between the SLC6A3 VNTR 9-repeat allele and alcoholism-a meta-analysis.Alcohol Clin Exp Res. 2011 Sep;35(9):1625-34. doi: 10.1111/j.1530-0277.2011.01509.x. Epub 2011 May 9.
• [9] Reduced expression of circadian clock genes in male alcoholic patients.Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.