Details of Disease

General Information of Disease (ID: DIS3K4KK)

• Disease Name: Alcohol-related disorders
• Synonyms: disorder, alcohol-related; alcohol related disorders; alcohol-related disorder; disorders, alcohol-related
• Definition: Disorders related to or resulting from abuse or mis-use of alcohol.
• Disease Hierarchy:
  :
  DIS3K4KK: Alcohol-related disorders
• Disease Identifiers:
  MONDO ID: MONDO_0021698
  MESH ID: D019973
  UMLS CUI: C0236664
  MedGen ID: 68632

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALDH2	TTFLN4T	Limited	Biomarker	[1]
ESRRG	TT9ZRHB	moderate	Genetic Variation	[2]
FTO	TTFW3BT	moderate	Genetic Variation	[3]
GRK5	TTTCXO0	moderate	Genetic Variation	[4]
KCNJ6	TTTIBVP	moderate	Genetic Variation	[5]
MBNL2	TTH9OLG	moderate	Genetic Variation	[6]
SEMA3A	TTVKD3S	moderate	Genetic Variation	[2]
NPR1	TTM9IYA	Strong	Biomarker	[7]
NPY	TT64REZ	Strong	Biomarker	[8]
AVPR1B	TTL9MHW	Definitive	Biomarker	[9]
GGT1	TTZVT7O	Definitive	Biomarker	[10]
SLC29A1	TTLXAKE	Definitive	Biomarker	[11]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A8	DTLPQGT	moderate	Genetic Variation	[3]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH1C	DEM1HNL	moderate	Genetic Variation	[3]
ADH4	DEOCWU3	moderate	Genetic Variation	[3]
ADH1B	DEEN9RD	Strong	Genetic Variation	[3]

This Disease Is Related to 25 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGBL4	OTOX2H61	moderate	Genetic Variation	[12]
ANKS1B	OT26DGM9	moderate	Genetic Variation	[12]
ARL15	OT00YSWZ	moderate	Genetic Variation	[13]
BRAP	OTB7BAFQ	moderate	Genetic Variation	[14]
CCSER1	OTVLD4J3	moderate	Genetic Variation	[4]
CSRNP3	OTOANEHZ	moderate	Genetic Variation	[4]
CTNNA2	OTJ8G92T	moderate	Genetic Variation	[12]
FAM162A	OT882DND	moderate	Genetic Variation	[4]
FSTL5	OT18C29S	moderate	Genetic Variation	[4]
GCKR	OTSIWXGG	moderate	Genetic Variation	[3]
IGSF22	OTQRM8GQ	moderate	Genetic Variation	[4]
IGSF9B	OTNOMYYQ	moderate	Genetic Variation	[2]
KLF12	OTVH4KD4	moderate	Genetic Variation	[2]
LHPP	OT9AGAIJ	moderate	Genetic Variation	[15]
MICB	OTS2DVDW	moderate	Genetic Variation	[3]
MREG	OT0LUIRG	moderate	Genetic Variation	[16]
NCALD	OTJZ8UEL	moderate	Genetic Variation	[2]
NRXN1	OTJN1JQA	moderate	Genetic Variation	[17]
PECR	OT5MS8EM	moderate	Genetic Variation	[16]
PLGRKT	OT5ITHAW	moderate	Genetic Variation	[4]
PPP1R16B	OTZJFX5C	moderate	Genetic Variation	[18]
RHBDL2	OTJPJ8N6	moderate	Genetic Variation	[2]
SERINC2	OTZ039U0	moderate	Genetic Variation	[19]
STAG3	OTEV0AOD	moderate	Genetic Variation	[2]
CARTPT	OTTE4V9S	Strong	Biomarker	[20]

References

• [1] Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees.Drug Alcohol Depend. 2015 Feb 1;147:130-6. doi: 10.1016/j.drugalcdep.2014.11.034. Epub 2014 Dec 13.
• [2] Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275.
• [3] Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Nat Commun. 2019 Apr 2;10(1):1499. doi: 10.1038/s41467-019-09480-8.
• [4] Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Am J Med Genet B Neuropsychiatr Genet. 2017 Dec;174(8):846-853. doi: 10.1002/ajmg.b.32604. Epub 2017 Oct 9.
• [5] Family-based genome-wide association study of frontal oscillations identifies potassium channel gene KCNJ6.Genes Brain Behav. 2012 Aug;11(6):712-9. doi: 10.1111/j.1601-183X.2012.00803.x. Epub 2012 May 31.
• [6] A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Biol Psychiatry. 2011 Sep 15;70(6):513-8. doi: 10.1016/j.biopsych.2011.02.028. Epub 2011 May 6.
• [7] Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors.Alcohol Alcohol. 2010 Jan-Feb;45(1):13-6. doi: 10.1093/alcalc/agp065. Epub 2009 Oct 13.
• [8] Neuropeptide y: role in emotion and alcohol dependence.CNS Neurol Disord Drug Targets. 2006 Apr;5(2):181-95. doi: 10.2174/187152706776359592.
• [9] Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats.Addict Biol. 2012 Jan;17(1):76-85. doi: 10.1111/j.1369-1600.2010.00291.x. Epub 2011 Feb 11.
• [10] Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism.Pharmacol Biochem Behav. 1980;13 Suppl 1:95-9. doi: 10.1016/s0091-3057(80)80015-3.
• [11] The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.Nat Neurosci. 2004 Aug;7(8):855-61. doi: 10.1038/nn1288. Epub 2004 Jul 18.
• [12] Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Mol Psychiatry. 2021 Apr;26(4):1152-1161. doi: 10.1038/s41380-019-0497-y. Epub 2019 Aug 28.
• [13] Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Drug Alcohol Depend. 2014 Sep 1;142:56-62. doi: 10.1016/j.drugalcdep.2014.05.023. Epub 2014 Jun 11.
• [14] Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.Transl Psychiatry. 2019 Oct 7;9(1):249. doi: 10.1038/s41398-019-0586-3.
• [15] The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.Neuropsychopharmacology. 2017 Feb;42(3):598-605. doi: 10.1038/npp.2016.153. Epub 2016 Aug 17.
• [16] Genome-wide association study of alcohol dependence.Arch Gen Psychiatry. 2009 Jul;66(7):773-84. doi: 10.1001/archgenpsychiatry.2009.83.
• [17] A genome-wide association study of behavioral disinhibition.Behav Genet. 2013 Sep;43(5):363-73. doi: 10.1007/s10519-013-9606-x. Epub 2013 Aug 14.
• [18] Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.Genes (Basel). 2017 Jul 17;8(7):183. doi: 10.3390/genes8070183.
• [19] NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.Drug Alcohol Depend. 2013 May 1;129(3):254-64. doi: 10.1016/j.drugalcdep.2013.02.006. Epub 2013 Feb 28.
• [20] Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.Addict Biol. 2014 Mar;19(2):175-84. doi: 10.1111/j.1369-1600.2012.00475.x. Epub 2012 Jul 24.