Details of Disease | DrugMAP

General Information of Disease (ID: DISGLR2C)

Disease Name	Familial ovarian cancer
Synonyms	familial ovarian malignant tumour; hereditary ovarian cancer; familial ovarian malignant tumor; familial ovarian cancer
Definition	An instance of ovarian cancer that is caused by an inherited modification of the individual's genome.
Disease Hierarchy	DISYKSRF: Genetic disease DISZJHAP: Ovarian cancer DISGLR2C: Familial ovarian cancer
Disease Identifiers	MONDO ID MONDO_0016248 UMLS CUI C5679802 MedGen ID 1803368 Orphanet ID 213517 SNOMED CT ID 1196879002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 19 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
XRCC2	OTJB2PV4	No Known	Autosomal dominant	[1]
CDH1	OTFJMXPM	No Known	Autosomal dominant	[1]
CHEK1	OTTTI622	No Known	Autosomal dominant	[1]
GEN1	OT1XFQXF	No Known	Autosomal dominant	[1]
MCPH1	OTYT3TT5	No Known	Autosomal dominant	[1]
NF1	OTC29NHH	No Known	Autosomal dominant	[1]
PIK3CA	OTTOMI8J	No Known	Autosomal dominant	[1]
RECQL	OTPCH3JH	No Known	Autosomal dominant	[1]
RINT1	OTMO19ZD	No Known	Autosomal dominant	[1]
SLX4	OTF6236I	No Known	Autosomal dominant	[1]
STK11	OT1YZSP3	No Known	Autosomal dominant	[1]
MRE11	OTGU8TZM	Refuted	Autosomal dominant	[1]
RAD50	OTYMU9G1	Refuted	Autosomal dominant	[1]
ATM	OTQVOHLT	Limited	Autosomal dominant	[1]
BARD1	OTTC0Z9Y	Limited	Autosomal dominant	[1]
CHEK2	OT8ZPCNS	Disputed	Autosomal dominant	[1]
MUTYH	OTXTKI7Q	Disputed	Autosomal recessive	[1]
PALB2	OT6DNDBG	Moderate	Autosomal dominant	[1]
BRIP1	OT38QBD4	Definitive	Autosomal dominant	[1]
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⏷ Show the Full List of 19 DOT(s)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDH1	TTLAWO6	No Known	Autosomal dominant	[1]
CHEK1	TTTU902	No Known	Autosomal dominant	[1]
PIK3CA	TTEUNMR	No Known	Autosomal dominant	[1]
ATM	TTKBM7V	Limited	Autosomal dominant	[1]
CHEK2	TT9ABMF	Disputed	Autosomal dominant	[1]
MUTYH	TTNB0ZK	Disputed	Autosomal recessive	[1]
BRIP1	TTZV7LJ	Definitive	Autosomal dominant	[1]
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⏷ Show the Full List of 7 DTT(s)

References

1	Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.