Details of Disease

General Information of Disease (ID: DISGVGNQ)

• Disease Name: Penile cancer
• Synonyms: penile neoplasm; penis cancer; penile cancer; penile Ca; malignant tumour of the penis; malignant tumour of penis; malignant tumor of the penis; malignant tumor of penis; malignant penis neoplasm; malignant penile tumour; malignant penile tumor; malignant penile neoplasm; malignant neoplasm of the penis; malignant neoplasm of penis; malignant neoplasm of body of penis; cancer of penis; Ca penis
• Definition: A primary or metastatic malignant neoplasm that affects the penis. Representative examples include penile carcinoma and penile sarcoma.
• Disease Hierarchy:
  DISAT1Z9: Advanced cancer
  DIS0RQDP: Male reproductive organ cancer
  DISFKEQJ: Penile neoplasm
  DISGVGNQ: Penile cancer
• Disease Identifiers:
  MONDO ID: MONDO_0001325
  MESH ID: D010412
  UMLS CUI: C0153601
  MedGen ID: 102277
  Orphanet ID: 398043
  SNOMED CT ID: 363516004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bleomycin	DMNER5S	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KRAS	TTM8FR7	Limited	Biomarker	[2]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CEACAM19	OTMECF5R	Strong	Altered Expression	[3]
CSN1S1	OTXOW6XJ	Strong	Genetic Variation	[4]
GPS1	OT97FRYE	Strong	Genetic Variation	[4]
RASSF2	OT2JHDO4	Strong	Posttranslational Modification	[5]
RPS29	OTCC1872	Strong	Genetic Variation	[6]

References

• [1] Bleomycin FDA Label
• [2] PIK3CA, HRAS and KRAS gene mutations in human penile cancer.J Urol. 2008 May;179(5):2030-4. doi: 10.1016/j.juro.2007.12.040. Epub 2008 Mar 19.
• [3] Aberrant CEACAM19 expression is associated with metastatic phenotype in penile cancer.Cancer Manag Res. 2019 Jan 14;11:715-725. doi: 10.2147/CMAR.S192385. eCollection 2019.
• [4] CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.Cancer Res. 2016 Aug 15;76(16):4720-4727. doi: 10.1158/0008-5472.CAN-15-3134. Epub 2016 Jun 20.
• [5] Differential gene hypermethylation in genital lichen sclerosus and cancer: a comparative study.Histopathology. 2013 Nov;63(5):659-69. doi: 10.1111/his.12204. Epub 2013 Sep 2.
• [6] Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.Sex Transm Infect. 2019 Feb;95(1):28-35. doi: 10.1136/sextrans-2018-053606. Epub 2018 Sep 21.