Details of Disease

Disease Name

Q fever pneumonia; Coxiella burnetii fever; Coxiella burnetii disease or disorder; nine Mile fever; Coxiellosis; quadrilateral fever; Coxiella burnetii infectious disease; query fever; infection due to Coxiella burnetii; Coxiella burnetii caused disease or disorder

Definition

A bacterial infection caused by Coxiella burnetii. It is transmitted to humans by the inhalation of infected air particles or contact with fluids and feces of infected animals. Signs and symptoms include the abrupt onset of fever, headache, myalgias, and weakness.

Disease Hierarchy

DISGFCIX: Vector-borne disease

DIS8ZVFW: Primary bacterial infectious disease

DISEM33Q: Infectious disease

DISK1S90: Q fever

Disease Identifiers

MONDO ID

MONDO_0019186

MESH ID

D011778

UMLS CUI

C0034362

MedGen ID

48290

Orphanet ID

781

SNOMED CT ID

186788009

General Information of Disease (ID: DISK1S90)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Tetracycline	DMZA017	Approved	Small molecular drug	[7]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DHCR24	TTTK0NH	Limited	Biomarker	[8]
HMGCR	TTPADOQ	Limited	Biomarker	[8]
LDLR	TTH0DUS	Limited	Biomarker	[8]
LSS	TT7O8ZA	Limited	Biomarker	[8]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FLOT1	OT0JPPJZ	Limited	Biomarker	[8]
NUPR1	OT4FU8C0	Limited	Biomarker	[9]
RBBP8	OTRHJ3GI	Limited	Biomarker	[9]
SNRNP70	OTP52YZ3	Limited	Genetic Variation	[10]
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References

1	Amphotericin B FDA Label
2	Demeclocycline FDA Label
3	Doxycycline FDA Label
4	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
5	Minocycline FDA Label
6	Oxytetracycline FDA Label
7	Tetracycline FDA Label
8	Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism.Cell Microbiol. 2006 Mar;8(3):496-507. doi: 10.1111/j.1462-5822.2005.00641.x.
9	Coxiella burnetii in sewage water at sewage water treatment plants in a Q fever epidemic area.Int J Hyg Environ Health. 2013 Nov;216(6):698-702. doi: 10.1016/j.ijheh.2012.12.010. Epub 2013 Jan 22.
10	A Q Fever Outbreak with a High Rate of Abortions at a Dairy Goat Farm: Coxiella burnetii Shedding, Environmental Contamination, and Viability.Appl Environ Microbiol. 2018 Oct 1;84(20):e01650-18. doi: 10.1128/AEM.01650-18. Print 2018 Oct 15.