Details of Disease | DrugMAP

General Information of Disease (ID: DISNPHO6)

Disease Name	Pulmonary edema
Synonyms	edema, pulmonary
Definition	Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure).
Disease Hierarchy	DIS5KQ5Y: Acute respiratory failure DISNPHO6: Pulmonary edema
Disease Identifiers	MONDO ID MONDO_0006932 MESH ID D011654 UMLS CUI C0034063 MedGen ID 11026 HPO ID HP:0100598 SNOMED CT ID 19242006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADA	TTLP57V	Strong	Biomarker	[1]
ADIPOQ	TTXKA7D	Strong	Therapeutic	[2]
ADRB2	TTG8ZWP	Strong	Biomarker	[3]
ALOX5	TTSJ6Q4	Strong	Biomarker	[4]
IL17A	TTG0MT6	Strong	Biomarker	[5]
NOS3	TTCM4B3	Strong	Therapeutic	[6]
TGFA	TTTLQFR	Strong	Therapeutic	[7]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SCNN1A	OTE2KVZV	Limited	Biomarker	[8]
GHRH	OT94U6MO	Strong	Therapeutic	[9]
SGMS1	OTZQE7PW	Strong	Biomarker	[10]
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References

1	Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement.Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L755-67. doi: 10.1152/ajplung.00330.2009. Epub 2010 Mar 12.
2	Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat. PLoS One. 2015 May 6;10(5):e0125169. doi: 10.1371/journal.pone.0125169. eCollection 2015.
3	Increased reabsorption of alveolar edema fluid in the obese Zucker rat.Tohoku J Exp Med. 2008 Nov;216(3):223-30. doi: 10.1620/tjem.216.223.
4	Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids.Am J Respir Crit Care Med. 1994 Jan;149(1):34-40. doi: 10.1164/ajrccm.149.1.8111595.
5	Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.Inflammation. 2017 Oct;40(5):1509-1519. doi: 10.1007/s10753-017-0592-7.
6	Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2743-51. doi: 10.1152/ajpheart.00347.2006. Epub 2006 Jul 14.
7	Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha.Am J Respir Cell Mol Biol. 2002 Apr;26(4):430-7. doi: 10.1165/ajrcmb.26.4.4594.
8	Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice.J Physiol. 2004 Nov 1;560(Pt 3):857-65. doi: 10.1113/jphysiol.2004.066704. Epub 2004 Aug 12.
9	Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2084-9. doi: 10.1073/pnas.1121075109. Epub 2012 Jan 23.
10	MOB-1 and TNF-alpha interact to induce microvascular lung injury.Shock. 2002 Sep;18(3):261-4. doi: 10.1097/00024382-200209000-00010.