Details of Disease | DrugMAP

General Information of Disease (ID: DISOHHFC)

Disease Name	Ocular melanoma
Synonyms	OM; eye melanoma (disease); melanoma (disease) of eyeball of camera-type eye; eye melanoma; melanoma of eye; melanoma of the eye; eyeball of camera-type eye melanoma; ocular melanoma; eyeball of camera-type eye melanoma (disease)
Definition	A melanoma that arises from the structures of the eye or ocular adnexa.
Disease Hierarchy	DISV2EVE: Ocular cancer DIS1RRCY: Melanoma DISOHHFC: Ocular melanoma
Disease Identifiers	MONDO ID MONDO_0006325 UMLS CUI C0558356 MedGen ID 107846 SNOMED CT ID 274087000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABI2	OT8GIIS5	Strong	Biomarker	[1]
ACTRT1	OTHFKSIZ	Strong	Biomarker	[1]
ARL6IP1	OT536XAV	Strong	Biomarker	[1]
CD177	OTS79FNF	Strong	Genetic Variation	[2]
HINT2	OTW9GS0U	Strong	Altered Expression	[3]
PDCD6	OT2YA5M8	Strong	Biomarker	[1]
PDCD6IP	OTS8T6A7	Strong	Biomarker	[1]
PHPT1	OTFYWNFX	Strong	Biomarker	[4]
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⏷ Show the Full List of 8 DOT(s)

References

1	Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.Biochemistry. 2004 Sep 7;43(35):11175-86. doi: 10.1021/bi048848d.
2	KIT mutations in ocular melanoma: frequency and anatomic distribution.Mod Pathol. 2011 Aug;24(8):1031-5. doi: 10.1038/modpathol.2011.57. Epub 2011 Apr 8.
3	m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation.Mol Cancer. 2019 Nov 14;18(1):161. doi: 10.1186/s12943-019-1088-x.
4	Embolization of variant hepatic arteries in patients undergoing percutaneous hepatic perfusion for unresectable liver metastases from ocular melanoma.Diagn Interv Radiol. 2019 Nov;25(6):451-458. doi: 10.5152/dir.2019.18138.