Details of Disease

General Information of Disease (ID: DISRPMMS)

• Disease Name: Lichen planus
• Synonyms: ruber planus; lichen, ruber planus; lichen ruber planus
• Definition: A chronic, recurrent, pruritic inflammatory disorder of unknown etiology that affects the skin and mucus membranes. It presents with rashes and papules that tend to resolve spontaneously. It may be associated with hepatitis C. Certain drugs that contain arsenic or bismuth are associated with reactions mimicking lichen planus.
• Disease Hierarchy:
  :
  DISY5SZC: Dermatitis
  DISRPMMS: Lichen planus
• Disease Identifiers:
  MONDO ID: MONDO_0006572
  MESH ID: D008010
  UMLS CUI: C0023646
  MedGen ID: 9753
  SNOMED CT ID: 4776004

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDA	TTQ12RK	Strong	Altered Expression	[1]
CLEC4C	TT7YT06	Strong	Biomarker	[2]
DSG3	TTEO4P8	Strong	Biomarker	[3]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IVL	OT4VPNGY	moderate	Altered Expression	[4]
TCHHL1	OTAMOJGN	moderate	Altered Expression	[5]
CARD18	OTBMLB80	Strong	Altered Expression	[6]
COL17A1	OTID5AH2	Strong	Altered Expression	[7]
DCD	OTV5PBGJ	Strong	Biomarker	[8]
ERVW-1	OTWV8DXJ	Strong	Biomarker	[1]
FLG	OTE9QDV6	Strong	Altered Expression	[9]
GNLY	OTZJKA8C	Strong	Altered Expression	[10]
HOPX	OTBSR6C9	Strong	Altered Expression	[11]
SERPINB4	OT88LHZ8	Strong	Altered Expression	[12]

References

• [1] Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of patients with lichen planus.Arch Dermatol Res. 2015 Apr;307(3):259-64. doi: 10.1007/s00403-014-1524-0. Epub 2014 Nov 11.
• [2] Possible role of plasmacytoid dendritic cells in pityriasis lichenoides.Clin Exp Dermatol. 2018 Jun;43(4):404-409. doi: 10.1111/ced.13351. Epub 2018 Jan 19.
• [3] Autoantibodies to desmogleins 1 and 3 in patients with lichen planus.Arch Dermatol Res. 2017 Sep;309(7):579-583. doi: 10.1007/s00403-017-1756-x. Epub 2017 Jul 3.
• [4] Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease: Alterations in Skin Barrier Function and Related Molecules.Chin Med J (Engl). 2017 Jun 20;130(12):1459-1466. doi: 10.4103/0366-6999.207475.
• [5] Trichohyalin-like 1 protein, a member of fused S100 proteins, is expressed in normal and pathologic human skin.Biochem Biophys Res Commun. 2013 Mar 1;432(1):66-72. doi: 10.1016/j.bbrc.2013.01.084. Epub 2013 Jan 29.
• [6] The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus.J Dermatol Sci. 2017 Aug;87(2):176-182. doi: 10.1016/j.jdermsci.2017.04.015. Epub 2017 May 1.
• [7] Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus.Int J Dermatol. 2016 Jun;55(6):634-9. doi: 10.1111/ijd.12990. Epub 2015 Nov 13.
• [8] Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development.Arch Dermatol Res. 2019 Jan;311(1):71-82. doi: 10.1007/s00403-018-1882-0. Epub 2018 Dec 3.
• [9] Increased regulatory T cells and eosinophils characterize atopic dermatitis-like graft-versus-host disease compared with lichen planus-like graft-versus-host disease.J Am Acad Dermatol. 2020 Sep;83(3):824-831. doi: 10.1016/j.jaad.2019.08.005. Epub 2019 Aug 9.
• [10] Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus.J Cutan Pathol. 2008 Jul;35(7):630-4. doi: 10.1111/j.1600-0560.2007.00892.x. Epub 2008 Mar 10.
• [11] Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes.Eur J Cell Biol. 2011 Apr;90(4):279-90. doi: 10.1016/j.ejcb.2010.11.001. Epub 2011 Jan 22.
• [12] Measurement of squamous cell carcinoma antigen 2 in lichen planus patients.J Cosmet Dermatol. 2020 Jul;19(7):1780-1784. doi: 10.1111/jocd.13216. Epub 2019 Dec 9.