Details of Disease

General Information of Disease (ID: DISRQ5X8)

Disease Name Polyarteritis nodosa
Synonyms periarteritis; polyarteritis; panarteritis nodosa; Kssmaul-Maier disease; polyarteritis nodosa; PAN; classic polyarteritis nodosa; classical polyarteritis nodosa; periarteritis nodosa
Definition
Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.
Disease Hierarchy
DIS0R34X: Arteritis
DISRQ5X8: Polyarteritis nodosa
Disease Identifiers
MONDO ID
MONDO_0019170
MESH ID
D010488
UMLS CUI
C0031036
MedGen ID
14681
Orphanet ID
767
SNOMED CT ID
155441006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CLDN18 TT6PKBX Strong Genetic Variation [1]
ERAP2 TTVGS1C Strong Genetic Variation [2]
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This Disease Is Related to 14 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
GCA OTAJ7ZHG Limited Genetic Variation [3]
ADA2 OTGCV24S Moderate Autosomal recessive [4]
ADGRG1 OTQBB8NT Strong Biomarker [5]
CHMP3 OT0963JJ Strong Altered Expression [6]
CIP2A OTVS2GXA Strong Altered Expression [7]
CRTAC1 OT4PGEVE Strong Biomarker [8]
ENTPD5 OTFH05B9 Strong Genetic Variation [9]
HHLA2 OTYBTVQS Strong Biomarker [10]
POTED OTAUSTUK Strong Altered Expression [11]
PRMT2 OT63JZCI Strong Biomarker [12]
PRPF8 OTU39JZI Strong Biomarker [13]
RAD52 OT0OTDHI Strong Altered Expression [14]
SLFN11 OTJWFPMY Strong Biomarker [15]
TREH OTJE0NOY Strong Altered Expression [16]
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⏷ Show the Full List of 14 DOT(s)

References

1 Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.Clin Cancer Res. 2008 Dec 1;14(23):7624-34. doi: 10.1158/1078-0432.CCR-08-1547.
2 Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration.Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11701-E11710. doi: 10.1073/pnas.1804506115. Epub 2018 Nov 21.
3 Are the 1990 American College of Rheumatology vasculitis classification criteria still valid?.Rheumatology (Oxford). 2017 Jul 1;56(7):1154-1161. doi: 10.1093/rheumatology/kex075.
4 The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
5 GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma.Cell Rep. 2017 Nov 21;21(8):2183-2197. doi: 10.1016/j.celrep.2017.10.083.
6 miR-122-5p promotes aggression and epithelial-mesenchymal transition in triple-negative breast cancer by suppressing charged multivesicular body protein 3 through mitogen-activated protein kinase signaling.J Cell Physiol. 2020 Mar;235(3):2825-2835. doi: 10.1002/jcp.29188. Epub 2019 Sep 20.
7 Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma.Biochem Biophys Res Commun. 2018 Jan 8;495(2):1807-1814. doi: 10.1016/j.bbrc.2017.11.124. Epub 2017 Nov 21.
8 LOTUS: A single- and multitask machine learning algorithm for the prediction of cancer driver genes.PLoS Comput Biol. 2019 Sep 30;15(9):e1007381. doi: 10.1371/journal.pcbi.1007381. eCollection 2019 Sep.
9 Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8433-E8442. doi: 10.1073/pnas.1612711114. Epub 2016 Dec 12.
10 Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis.Front Immunol. 2019 Jul 15;10:1573. doi: 10.3389/fimmu.2019.01573. eCollection 2019.
11 Expression of the POTE gene family in human ovarian cancer.Sci Rep. 2018 Nov 20;8(1):17136. doi: 10.1038/s41598-018-35567-1.
12 PRMT2 and ROR expression are associated with breast cancer survival outcomes.Mol Endocrinol. 2014 Jul;28(7):1166-85. doi: 10.1210/me.2013-1403. Epub 2014 Jun 9.
13 Mutational landscape of RNA-binding proteins in human cancers.RNA Biol. 2018 Jan 2;15(1):115-129. doi: 10.1080/15476286.2017.1391436. Epub 2017 Nov 14.
14 Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.DNA Repair (Amst). 2017 Jul;55:64-75. doi: 10.1016/j.dnarep.2017.04.006. Epub 2017 May 10.
15 Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy.PLoS One. 2019 Nov 4;14(11):e0224267. doi: 10.1371/journal.pone.0224267. eCollection 2019.
16 Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.Pediatr Res. 2011 Jul;70(1):83-9. doi: 10.1203/PDR.0b013e31821bdf1c.