Details of Disease

General Information of Disease (ID: DISTGIGF)

• Disease Name: Malignant tumor of nasopharynx
• Synonyms: malignant nasopharyngeal tumour; malignant nasopharyngeal tumor; cancer of nasopharynx; malignant tumour of the nasopharynx; malignant nasopharynx neoplasm; malignant neoplasm of the nasopharynx; nasopharynx cancer; malignant tumor of the nasopharynx; malignant neoplasm of nasopharynx; malignant nasopharyngeal neoplasm
• Definition: A cancer that involves the nasopharynx.
• Disease Hierarchy:
  :
  DISXLF8Z: Pharynx cancer
  DISAT1Z9: Advanced cancer
  DISTGIGF: Malignant tumor of nasopharynx
• Disease Identifiers:
  MONDO ID: MONDO_0021315
  UMLS CUI: C0153392
  MedGen ID: 56299
  SNOMED CT ID: 187692001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NFKBIA	TTSHAEB	Strong	SomaticCausalMutation	[1]

This Disease Is Related to 25 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BCL2L12	OTS6IFZY	Limited	Altered Expression	[2]
HAT1	OT307KEN	Limited	Altered Expression	[2]
HLA-DRB4	OTNXIHQU	Limited	Genetic Variation	[3]
KIF20A	OTXOQHE0	Limited	Altered Expression	[4]
NPAS2	OTMRT2TS	Limited	Biomarker	[5]
PCDH17	OTRK0M05	Limited	Posttranslational Modification	[6]
RAB27B	OTPF9D0K	Limited	Biomarker	[7]
RPA1	OT76POLP	Limited	Altered Expression	[8]
SUN1	OTIU8V4U	Limited	Biomarker	[9]
TBX2	OTTOT7A9	Limited	Altered Expression	[10]
ARHGAP42	OTIDSJMK	moderate	Altered Expression	[11]
IMMT	OTBDSLE7	moderate	Genetic Variation	[12]
KIF2A	OT2WQ6QD	moderate	Biomarker	[12]
NAA80	OTLWR71Z	moderate	Genetic Variation	[13]
PHF20	OTCBVH5P	moderate	Biomarker	[12]
PRDM13	OTUNAFQW	moderate	Biomarker	[12]
RAB18	OTNMAQLS	moderate	Biomarker	[12]
TRIP6	OTIPA4ZR	moderate	Biomarker	[14]
ADAMTS9	OTV3Q0DS	Strong	Biomarker	[15]
BPIFA1	OTQFD2J5	Strong	Biomarker	[16]
MDC1	OTEUQH4J	Strong	Biomarker	[17]
MUC5B	OTPW6K5C	Strong	Biomarker	[18]
OSCP1	OTZ4IFGJ	Strong	Biomarker	[19]
PIGR	OT6GLSUL	Strong	Genetic Variation	[20]
RBL2	OTBQSOE6	Strong	Biomarker	[21]

References

• [1] Whole-exome sequencing identifies multiple loss-of-function mutations of NF-B pathway regulators in nasopharyngeal carcinoma.Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11283-11288. doi: 10.1073/pnas.1607606113. Epub 2016 Sep 19.
• [2] Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells.Arch Biochem Biophys. 2018 May 15;646:72-79. doi: 10.1016/j.abb.2018.03.040. Epub 2018 Apr 3.
• [3] Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.Int J Oncol. 2000 May;16(5):917-25. doi: 10.3892/ijo.16.5.917.
• [4] Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.PLoS One. 2017 Jan 12;12(1):e0169280. doi: 10.1371/journal.pone.0169280. eCollection 2017.
• [5] MiR-20a-5p promotes radio-resistance by targeting NPAS2 in nasopharyngeal cancer cells.Oncotarget. 2017 Nov 11;8(62):105873-105881. doi: 10.18632/oncotarget.22411. eCollection 2017 Dec 1.
• [6] Aberrant promoter methylation reduced the expression of protocadherin 17 in nasopharyngeal cancer.Biochem Cell Biol. 2019 Aug;97(4):364-368. doi: 10.1139/bcb-2017-0343. Epub 2018 Aug 30.
• [7] MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells.Cancer Cell Int. 2017 Mar 1;17:32. doi: 10.1186/s12935-017-0389-7. eCollection 2017.
• [8] RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.Exp Cell Res. 2018 Oct 15;371(2):330-341. doi: 10.1016/j.yexcr.2018.08.025. Epub 2018 Aug 23.
• [9] Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p.Biomed Pharmacother. 2018 Jul;103:473-481. doi: 10.1016/j.biopha.2018.03.121. Epub 2018 Apr 24.
• [10] TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion.Oncotarget. 2017 Apr 13;8(32):52699-52707. doi: 10.18632/oncotarget.17084. eCollection 2017 Aug 8.
• [11] ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma.Cancer Med. 2018 Aug;7(8):3862-3874. doi: 10.1002/cam4.1552. Epub 2018 Jun 24.
• [12] Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.Int J Cancer. 2003 Aug 20;106(2):244-51. doi: 10.1002/ijc.11208.
• [13] Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer.Mol Cell Probes. 2004 Feb;18(1):39-44. doi: 10.1016/j.mcp.2003.09.002.
• [14] Characterization of TRIP6-dependent nasopharyngeal cancer cell migration.Tumour Biol. 2013 Aug;34(4):2329-35. doi: 10.1007/s13277-013-0780-5. Epub 2013 Apr 11.
• [15] ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.Am J Pathol. 2010 Mar;176(3):1494-504. doi: 10.2353/ajpath.2010.090655. Epub 2010 Jan 21.
• [16] SPLUNC1 is associated with nasopharyngeal carcinoma prognosis and plays an important role in all-trans-retinoic acid-induced growth inhibition and differentiation in nasopharyngeal cancer cells.FEBS J. 2014 Nov;281(21):4815-29. doi: 10.1111/febs.13020. Epub 2014 Sep 24.
• [17] Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.Cell Death Dis. 2015 Aug 6;6(8):e1849. doi: 10.1038/cddis.2015.214.
• [18] HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis.Cancer Sci. 2009 Feb;100(2):216-24. doi: 10.1111/j.1349-7006.2008.01028.x.
• [19] Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro.Int J Biochem Cell Biol. 2013 Sep;45(9):2016-26. doi: 10.1016/j.biocel.2013.06.020. Epub 2013 Jul 3.
• [20] Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer.BMC Genet. 2003 Jan 21;4:3. doi: 10.1186/1471-2156-4-3. Epub 2003 Jan 21.
• [21] Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma.Cancer Res. 2000 Jan 1;60(1):8-12.