Details of Disease

General Information of Disease (ID: DISTU5VE)

Disease Name	Coronary microvascular disease
Synonyms	heart disease of microvascular endothelium; coronary microvascular disease; microvascular endothelium heart disease; CMD
Disease Class	BA86: Coronary microvascular disease
Definition	A disorder affecting the smallest coronary arteries. Causes include atherosclerosis and arterial spasm. Chest pain is a frequently observed symptom.
Disease Hierarchy	DISVS67S: Vascular disease DISVO1I5: Cardiac disease DISTU5VE: Coronary microvascular disease
ICD Code	ICD-11 ICD-11: BA86
Disease Identifiers	MONDO ID MONDO_0044875 MESH ID D017566 UMLS CUI C0206064 MedGen ID 104771 SNOMED CT ID 233845001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CLBS16	DMGM8JV	Phase 2	Cell therapy	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BDKRB1	TTG5QIA	moderate	Altered Expression	[2]
IFNGR2	TT13TL0	moderate	Genetic Variation	[3]
SREBF1	TTER0UB	Strong	Biomarker	[4]
MTHFR	TTQWOU1	Definitive	Genetic Variation	[5]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MPI	OTBH6ZK1	moderate	Altered Expression	[6]
DAXX	OTX6O7PL	Strong	Altered Expression	[7]
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References

1	ClinicalTrials.gov (NCT03508609) An Open-Label Exploratory Clinical Study to Evaluate the Safety and Potential Bioactivity of CLBS16 in Patients With Coronary Microvascular Dysfunction (CMD) and Without Obstructive Coronary Artery Disease. U.S.National Institutes of Health.
2	Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X.Scand Cardiovasc J. 2007 Dec;41(6):391-6. doi: 10.1080/14017430701499379.
3	Transcriptional activity of genes encoding interferon gamma (IFNgamma) and its receptor assessed in peripheral blood mononuclear cells in patients with cardiac syndrome X.Inflammation. 2007 Aug;30(3-4):125-9. doi: 10.1007/s10753-007-9028-0. Epub 2007 Jun 2.
4	Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?.Expert Opin Ther Targets. 2004 Apr;8(2):141-9. doi: 10.1517/14728222.8.2.141.
5	Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients.J Clin Lab Anal. 2018 Feb;32(2):e22247. doi: 10.1002/jcla.22247. Epub 2017 May 8.
6	Assessment of the relationship between coronary flow rates and myocardial perfusion abnormality in patients with nonobstructive coronary artery disease: an observational study in cardiac syndrome X and coronary slow flow.Nucl Med Commun. 2019 Nov;40(11):1122-1129. doi: 10.1097/MNM.0000000000001080.
7	Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas.Histopathology. 2018 Jan;72(2):239-247. doi: 10.1111/his.13337. Epub 2017 Oct 19.