General Information of Disease (ID: DISVO1I5)

Disease Name Cardiac disease
Synonyms
heart disorder; heart/pericardial disease; heart/pericardial disease or disorder; disease of heart; heart/pericardial trouble; disorder of heart/pericardium; heart trouble; heart disease or disorder; heart disease; cardiac disease; heart/pericardial disorder; disorder of heart; disease or disorder of heart
Disease Class BA00-BE2Z: Cardiovascular disease
Definition A disease involving the heart and/or pericardium.
Disease Hierarchy
DISWD40R: Disease
DIS2IQDX: Cardiovascular disease
DISVO1I5: Cardiac disease
ICD Code
ICD-11
ICD-11: BA00-BE2Z
ICD-10
ICD-10: I00-I99
Disease Identifiers
MONDO ID
MONDO_0005267
MESH ID
D006331
UMLS CUI
C0018799
MedGen ID
5458
SNOMED CT ID
56265001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Denopamine DM8C3GN Approved Small molecular drug [1]
Ibopamine hci DMGUX67 Approved Small molecular drug [2]
Inamrinone Lactate DMRMFP4 Approved Small molecular drug [2]
Vitamin E DMZC90K Approved Small molecular drug [3]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Tezosentan DM52CGD Phase 3 Small molecular drug [4]
CL-284027 DMQIFG0 Phase 2 NA [5]
CMX-2043 DMPSCVY Phase 2 NA [6]
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This Disease is Treated as An Indication in 5 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Metazosin DMAZ28C Discontinued in Phase 3 Small molecular drug [7]
N-0861 DMNX0JH Discontinued in Phase 3 Small molecular drug [8]
FK-664 DMFGJNW Discontinued in Phase 2 Small molecular drug [9]
Istaroxime DMWN09H Discontinued in Phase 2 Small molecular drug [10]
OPC-21268 DM7OVMH Discontinued in Phase 2 Small molecular drug [11]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
DPN-205-734 DMSRUKQ Investigative Small molecular drug [12]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 121 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCC1 TTOI92F Limited Biomarker [13]
ABCC2 TTFLHJV Limited Biomarker [13]
ALB TTFNGC9 Limited Biomarker [14]
APLN TT87D3J Limited Biomarker [15]
APOB TTN1IE2 Limited Genetic Variation [16]
FGF23 TT2IZ4K Limited Biomarker [17]
GAST TT4LRVO Limited Genetic Variation [18]
GHRL TT1OCL0 Limited Genetic Variation [19]
GRK2 TTAZ3MN Limited Biomarker [20]
KCNH2 TTQ6VDM Limited Genetic Variation [21]
KCNQ1 TT846HF Limited Biomarker [22]
LPA TTU9LGY Limited Genetic Variation [23]
MYH7 TTNIMDP Limited Genetic Variation [24]
PTPN11 TT7WUAV Limited Biomarker [25]
RAPGEF3 TTOE7I0 Limited Altered Expression [26]
SIRT3 TTVZLIJ Limited Biomarker [27]
SLC25A1 TTTD730 Limited Biomarker [28]
TNNI3 TTNLDK6 Limited Biomarker [29]
ZUP1 TTZC0KV Limited Altered Expression [30]
ACE2 TTUI5H7 Disputed Biomarker [31]
MYBPC3 TT9WOBN Disputed Biomarker [32]
PDE5A TTJ0IQB Disputed Biomarker [33]
GDF15 TT4MXVG moderate Biomarker [34]
VEGFB TTPJQHE moderate Altered Expression [35]
ABCB1 TT3OT40 Strong Biomarker [36]
ABCC9 TTEF5MJ Strong Genetic Variation [37]
ADAMTS1 TTS2TEI Strong Altered Expression [38]
ADRA2A TTWG9A4 Strong Biomarker [36]
ADRB1 TTR6W5O Strong Biomarker [39]
AGT TT5C0UB Strong Biomarker [40]
ALDH2 TTFLN4T Strong Biomarker [41]
APEX1 TTHGL48 Strong Biomarker [42]
APLNR TTJ8E43 Strong Biomarker [43]
APOC3 TTXOZQ1 Strong Genetic Variation [44]
B2M TTY7FKA Strong Biomarker [36]
BAX TTQ57WJ Strong Biomarker [45]
CASP3 TTPF2QI Strong Biomarker [46]
CASP8 TT6SZNG Strong Biomarker [46]
CASP9 TTB6T7O Strong Biomarker [46]
CD36 TTPJMCU Strong Genetic Variation [47]
CDC20 TTBKFDV Strong Biomarker [48]
CHRM3 TTQ13Z5 Strong Biomarker [49]
CSF3 TT5TQ2W Strong Therapeutic [50]
CTF1 TTXGTZU Strong Altered Expression [51]
CYP11B1 TTIQUX7 Strong Biomarker [52]
CYP2J2 TTNE1C7 Strong Biomarker [53]
DMD TTWLFXU Strong Biomarker [54]
EDN1 TTJR60Z Strong Biomarker [55]
EP300 TTGH73N Strong Biomarker [56]
EPO TTQG4NR Strong Biomarker [57]
FABP3 TT3TGLR Strong Biomarker [58]
GATA4 TT1VDN2 Strong Genetic Variation [59]
GCG TT6Y4PN Strong Biomarker [60]
GJA3 TTFZRG0 Strong Genetic Variation [61]
GJA4 TTQO1VY Strong Genetic Variation [62]
GJA5 TTFQKZ7 Strong Genetic Variation [62]
GJA8 TTJ7ATH Strong Genetic Variation [61]
GJB6 TTAU8SJ Strong Genetic Variation [61]
GLA TTIS03D Strong Genetic Variation [63]
GRK3 TT5A4DX Strong Altered Expression [64]
GRK5 TTTCXO0 Strong Altered Expression [64]
GSK3B TTRSMW9 Strong Therapeutic [65]
HCN4 TTQP04A Strong Biomarker [66]
HDAC1 TT6R7JZ Strong Biomarker [67]
HDAC3 TT4YWTO Strong Biomarker [67]
HTR4 TT07C3Y Strong Biomarker [68]
HTT TTIWZ0O Strong Genetic Variation [69]
IL13RA1 TTNEAMG Strong Biomarker [70]
IL18 TTRICUF Strong Biomarker [71]
IL1RL1 TT4GZA4 Strong Altered Expression [72]
ITPR2 TTK9OV3 Strong Altered Expression [73]
JAK2 TTRMX3V Strong Biomarker [74]
JUP TTREN0G Strong Genetic Variation [75]
KCNH1 TT9XKUC Strong Biomarker [76]
KCNJ2 TTH7UO3 Strong Biomarker [77]
KHK TTPAFR9 Strong Biomarker [78]
KIR2DL2 TTU0P73 Strong Biomarker [79]
KIR2DL3 TTEX3SI Strong Biomarker [79]
KIR2DS2 TTV3CFI Strong Biomarker [79]
LAMP2 TTULDG7 Strong Altered Expression [80]
LGALS3 TTFPQV7 Strong Altered Expression [81]
LIPE TTLUQ8E Strong Biomarker [82]
MGAT1 TTYJRN5 Strong Altered Expression [83]
MUC16 TTC1PS3 Strong Biomarker [84]
NAGLU TTDM6HZ Strong Biomarker [85]
NEDD4 TT1QU6G Strong Biomarker [86]
NPC1L1 TTPD1CN Strong Genetic Variation [87]
NPPC TTRK0B9 Strong Biomarker [88]
NPR3 TTWVLS6 Strong Altered Expression [89]
OGG1 TTRU01G Strong Therapeutic [90]
PAH TTGSVH2 Strong Biomarker [91]
PDE9A TTZOEBC Strong Biomarker [92]
PLN TTMCVJF Strong Therapeutic [93]
PON1 TT9LX82 Strong Biomarker [94]
PPP2CA TTHTKNY Strong Biomarker [95]
PRKG1 TT7IZSA Strong Genetic Variation [96]
PTGIR TTOFYT1 Strong Biomarker [97]
RAB9A TT958S6 Strong Biomarker [98]
RARG TT1Q3IE Strong Biomarker [99]
REN TTB2MXP Strong Genetic Variation [100]
S1PR2 TTVSMOH Strong Biomarker [36]
SCN10A TT90XZ8 Strong Biomarker [101]
SCN5A TTZOVE0 Strong Genetic Variation [102]
SIRT1 TTUF2HO Strong Biomarker [103]
SIRT6 TTUXYWF Strong Biomarker [104]
SMAD6 TTON5JB Strong Altered Expression [105]
SPP1 TT8ME6I Strong Biomarker [106]
TH TTUHP71 Strong Biomarker [107]
THBS1 TTKI0H1 Strong Biomarker [108]
TMSB4X TTMVAIU Strong Biomarker [109]
TNNC1 TT8RDXP Strong Biomarker [110]
TNNT2 TTWAS18 Strong Biomarker [111]
TRPC3 TTNVC34 Strong Altered Expression [112]
TRPM4 TTJ2HKA Strong Biomarker [113]
TRPV2 TTBECWA Strong Biomarker [114]
TTR TTPOYU7 Strong Biomarker [115]
UBA1 TTXHWA7 Strong Biomarker [116]
VKORC1 TTEUC8H Strong Genetic Variation [117]
XDH TT7RJY8 Strong Biomarker [118]
APOE TTKS9CB Definitive Altered Expression [119]
GALNS TTT9YPO Definitive Genetic Variation [18]
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⏷ Show the Full List of 121 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC24A3 DTO18LP Strong Biomarker [120]
SLC4A3 DT4X2AH Strong Biomarker [36]
SLC7A9 DTP7AEQ Strong Genetic Variation [121]
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This Disease Is Related to 5 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP1A1 DE6OQ3W Strong Biomarker [122]
DIO3 DET89OV Strong Genetic Variation [123]
FXN DEXVHDB Strong Biomarker [124]
MT2A DEFKGT7 Strong Therapeutic [125]
UGT2B7 DEB3CV1 Strong Genetic Variation [126]
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This Disease Is Related to 126 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AGGF1 OTA7U2T8 Limited Biomarker [127]
ARHGEF12 OTM2D3LT Limited Biomarker [128]
DES OTI09KBW Limited Genetic Variation [129]
FAM20C OTW5YZ7X Limited Posttranslational Modification [130]
IMPACT OTQ923OB Limited Biomarker [131]
JPH2 OTL9YH7V Limited Genetic Variation [132]
MAP1S OT5WUD4C Limited Genetic Variation [133]
NCF4 OTX007YL Limited Biomarker [13]
PF4V1 OT2CXM6L Limited Biomarker [134]
RAC2 OTAOHFNH Limited Biomarker [13]
SCO1 OTC45UGB Limited Biomarker [135]
FSD1 OT8P6PT3 Disputed Genetic Variation [136]
FSD1L OTBQ48RF Disputed Genetic Variation [136]
RBM20 OTOQZNKS Disputed Biomarker [137]
DYM OTQ670WI moderate Biomarker [138]
GATA5 OTO81B63 moderate Genetic Variation [139]
HSPB6 OTFPLGZI moderate Biomarker [140]
ADAMTSL3 OTMC2WFG Strong Biomarker [141]
ADGRL4 OTN1GAG7 Strong Biomarker [142]
ANK2 OTWB4R1Y Strong Genetic Variation [143]
ANKRD1 OTHJ7JV9 Strong Biomarker [144]
APOA5 OTEVKLVA Strong Biomarker [145]
APOC1 OTA58CED Strong Biomarker [146]
ARSD OTAHW9M8 Strong Biomarker [147]
ARSL OTF1VTCR Strong Altered Expression [148]
ASXL2 OTNG4E2M Strong Altered Expression [149]
ATP5PF OTDAE8FP Strong Biomarker [36]
BEX1 OTBQIF0H Strong Biomarker [150]
BNIP3L OTJKOMXE Strong Biomarker [151]
BRAP OTB7BAFQ Strong Biomarker [152]
BSN OTZ72VIB Strong Biomarker [36]
BTBD8 OT3A3RD7 Strong Biomarker [153]
C1QTNF9 OTLI3VA3 Strong Altered Expression [154]
CAMK2D OTJ5XLVU Strong Biomarker [155]
CASP12 OTY2W6FG Strong Biomarker [46]
CASQ2 OT09MNQ8 Strong Biomarker [156]
CAV3 OTWSFDB4 Strong Biomarker [157]
CFC1 OT5DHGI8 Strong Genetic Variation [158]
CORIN OT4SK7DK Strong Genetic Variation [159]
CP OTM8JE4Y Strong Biomarker [160]
CRABP1 OTISDG5X Strong Biomarker [161]
CYBA OT16N9ZO Strong Genetic Variation [162]
DAND5 OTWNWQDJ Strong Biomarker [163]
DBT OT4KZ5R9 Strong Biomarker [164]
DDX39A OT0Z6E1K Strong Genetic Variation [121]
DDX39B OTEVCFVU Strong Genetic Variation [121]
DGKE OTWS86AS Strong Biomarker [165]
DNAH8 OTGES2OU Strong Biomarker [166]
DPP6 OTWW3H0K Strong Genetic Variation [167]
DSC2 OTODVH8K Strong Altered Expression [168]
DSG2 OTJPB2TO Strong Genetic Variation [169]
EFNA5 OTOH4DRR Strong Biomarker [170]
EHD3 OTOKC2G5 Strong Biomarker [171]
EMD OTR8ZANE Strong Biomarker [172]
EMILIN2 OTOYK5A8 Strong Altered Expression [173]
ENHO OT91QASK Strong Biomarker [174]
EPRS1 OTXK0FLB Strong Genetic Variation [175]
FHOD3 OT1WUBQX Strong Biomarker [137]
FXR1 OTEMQ1SR Strong Altered Expression [176]
HADHB OT4Y1I62 Strong Biomarker [177]
HAND1 OTN4IPVV Strong Biomarker [178]
HBG2 OT4J48JJ Strong Biomarker [179]
HEPH OTZ2F15Z Strong Biomarker [180]
HESX1 OT5E2Z4G Strong Biomarker [181]
HOXC5 OTPQTLKZ Strong Genetic Variation [182]
IMPA1 OTBUVW1Z Strong Biomarker [152]
ITIH4 OT460OO1 Strong Biomarker [183]
KCNE1 OTZNQUW9 Strong Genetic Variation [184]
KCNIP2 OTY4BLOJ Strong Biomarker [185]
KLF11 OTKVQDJD Strong Biomarker [186]
KLF13 OTMIKHZ4 Strong Genetic Variation [187]
LBH OT87AT1X Strong Biomarker [188]
LDB3 OTGQL1AM Strong Genetic Variation [189]
LOXL1 OTA0NEJU Strong Biomarker [190]
LOXL3 OTLLY1QI Strong Biomarker [190]
LTBP2 OTS88GSD Strong Altered Expression [191]
LTBP3 OTME98V7 Strong Genetic Variation [192]
MB OTYWYL2D Strong Genetic Variation [193]
MINK1 OTKB0RA8 Strong Genetic Variation [184]
MYL3 OTKD3RSX Strong Genetic Variation [194]
MYL4 OTURFCSE Strong Genetic Variation [195]
MYO6 OTJQYRC7 Strong Biomarker [196]
NCOA6 OTOMIGTV Strong Genetic Variation [197]
NFAT5 OTKIE59S Strong Biomarker [198]
NFATC1 OT4TMERS Strong Biomarker [199]
NKX2-5 OTS1SAWM Strong Genetic Variation [200]
NOX5 OTHTH59G Strong Biomarker [201]
NRIP1 OTIZOJQV Strong Altered Expression [202]
OBSCN OTT14OVX Strong Genetic Variation [203]
PAPPA OTTTG9PG Strong Altered Expression [204]
PKP2 OTJOVF68 Strong Genetic Variation [205]
PNPLA2 OTR3ERMR Strong Genetic Variation [206]
PPARGC1A OTHCDQ22 Strong Biomarker [207]
PRICKLE1 OT9HHEM9 Strong Genetic Variation [208]
PRKAG2 OTHTAM54 Strong Genetic Variation [209]
PSMA2 OTJRT2ZL Strong Biomarker [36]
PTOV1 OT94WT5X Strong Biomarker [210]
RAMP3 OTX6XLLM Strong Biomarker [211]
RHCE OTS18IZ5 Strong Biomarker [212]
RHOT2 OTV8WT2L Strong Biomarker [213]
RRAD OTW2O4GD Strong Biomarker [214]
RYR2 OT0PF19E Strong Genetic Variation [215]
SFRP1 OT0U9G41 Strong Biomarker [216]
SGCD OTRBL3NQ Strong Genetic Variation [217]
SPEG OTQXWJR4 Strong Biomarker [218]
SPRR2B OTQ9WPKY Strong Biomarker [219]
SRM OT4N5MDP Strong Biomarker [220]
SSB OTCCTPBR Strong Biomarker [221]
STRA6 OT2IDF27 Strong Genetic Variation [222]
TAB2 OTPZK76F Strong Genetic Variation [223]
TAB3 OT1ECMDL Strong Biomarker [224]
TAS2R50 OTPRMVZW Strong Genetic Variation [225]
TBX20 OTMPU2XQ Strong Genetic Variation [226]
TBX5 OT70PISV Strong Biomarker [227]
TCF4 OTB9ASTK Strong Biomarker [36]
TECR OT2NT4MV Strong Altered Expression [228]
THAP5 OT6ZMFYF Strong Altered Expression [229]
THBS2 OTXET551 Strong Biomarker [230]
TIMP1 OTOXC51H Strong Biomarker [231]
TIMP4 OT8A68SW Strong Altered Expression [232]
TLX2 OTPFAUM8 Strong Biomarker [120]
TPM1 OTD73X6R Strong Biomarker [233]
ADD3 OTDRSHAZ Definitive Biomarker [234]
MYOM2 OTD2UOXW Definitive Biomarker [235]
PAGR1 OTXR5PQ8 Definitive Genetic Variation [18]
TTN OT0LZ058 Definitive Biomarker [236]
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⏷ Show the Full List of 126 DOT(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 534).
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4 ClinicalTrials.gov (NCT00458276) Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery. U.S. National Institutes of Health.
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6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002056)
8 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003285)
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001589)
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010607)
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2196).
12 Pharmacological actions of DPN 205-734, a novel cardiotonic agent. J Cardiovasc Pharmacol. 1988 Oct;12(4):451-60.
13 NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation. 2005 Dec 13;112(24):3754-62.
14 Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease.J Agric Food Chem. 2019 Aug 21;67(33):9139-9147. doi: 10.1021/acs.jafc.8b06674. Epub 2019 Feb 28.
15 Apelin: A novel prognostic predictor for atrial fibrillation recurrence after pulmonary vein isolation.Medicine (Baltimore). 2018 Sep;97(39):e12580. doi: 10.1097/MD.0000000000012580.
16 Analysis of a variable number of tandem repeats in a heart disease gene by capillary electrophoresis with laser-induced fluorescence detector.Chem Pharm Bull (Tokyo). 1998 Feb;46(2):294-7. doi: 10.1248/cpb.46.294.
17 Strength of Fibroblast Growth Factor 23 as a Cardiovascular Risk Predictor in Chronic Kidney Disease Weaken by ProBNP Adjustment.Am J Nephrol. 2019;49(3):203-211. doi: 10.1159/000497125. Epub 2019 Feb 26.
18 Measuring Anxiety in Older Adults: Development, Diagnostic Accuracy, and Preliminary Validation of a Short-Form of the German Geriatric Anxiety Scale (GAS-G-SF).J Pers Assess. 2020 Mar-Apr;102(2):196-204. doi: 10.1080/00223891.2019.1677679. Epub 2019 Oct 18.
19 Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease.Hum Mol Genet. 2007 Apr 15;16(8):887-99. doi: 10.1093/hmg/ddm033. Epub 2007 Feb 26.
20 Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target.Nat Commun. 2018 Sep 11;9(1):3679. doi: 10.1038/s41467-018-06119-y.
21 Influence of genetic modifiers on sudden cardiac death cases.Int J Legal Med. 2018 Mar;132(2):379-385. doi: 10.1007/s00414-017-1739-7. Epub 2017 Dec 6.
22 Detection of genetic cardiac diseases by Ca(2+) transient profiles using machine learning methods.Sci Rep. 2018 Jun 19;8(1):9355. doi: 10.1038/s41598-018-27695-5.
23 Familial lipoprotein disorders and premature coronary artery disease.Atherosclerosis. 1994 Aug;108 Suppl:S41-54. doi: 10.1016/0021-9150(94)90152-x.
24 Hypertrophic cardiomyopathy R403Q mutation in rabbit -myosin reduces contractile function at the molecular and myofibrillar levels.Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11238-11243. doi: 10.1073/pnas.1802967115. Epub 2018 Oct 15.
25 The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Semin Cell Dev Biol. 2015 Jan;37:73-81. doi: 10.1016/j.semcdb.2014.09.013. Epub 2014 Sep 22.
26 Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777.
27 SIRT3: A New Regulator of Cardiovascular Diseases.Oxid Med Cell Longev. 2018 Feb 13;2018:7293861. doi: 10.1155/2018/7293861. eCollection 2018.
28 Serum carboxy-terminal telopeptide of type I collagen (I-CTP) is predictive of clinical outcome in peripheral artery disease patients following endovascular therapy.Heart Vessels. 2017 Feb;32(2):149-156. doi: 10.1007/s00380-016-0858-2. Epub 2016 Jun 1.
29 Abnormal Cardiac Biomarkers in Patients with Systemic Lupus Erythematosus and No Prior Heart Disease: A Consequence of Antimalarials?.J Rheumatol. 2019 Jan;46(1):64-69. doi: 10.3899/jrheum.171436. Epub 2018 Aug 1.
30 Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.J Mol Cell Cardiol. 2011 Apr;50(4):652-61. doi: 10.1016/j.yjmcc.2010.12.015. Epub 2010 Dec 30.
31 The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling.Oncotarget. 2017 Aug 17;8(42):72302-72314. doi: 10.18632/oncotarget.20305. eCollection 2017 Sep 22.
32 Demographic model for inheritable cardiac disease.Arch Biochem Biophys. 2019 Sep 15;672:108056. doi: 10.1016/j.abb.2019.07.021. Epub 2019 Jul 26.
33 Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.JCI Insight. 2018 Aug 9;3(15):e121739. doi: 10.1172/jci.insight.121739. eCollection 2018 Aug 9.
34 The clinical impact of growth differentiation factor-15 in heart disease: A 2019 update.Crit Rev Clin Lab Sci. 2020 Mar;57(2):114-125. doi: 10.1080/10408363.2019.1678565. Epub 2019 Oct 30.
35 VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21.
36 Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats.Toxicol Pathol. 2006;34(4):348-56. doi: 10.1080/01926230600798583.
37 Human K(ATP) channelopathies: diseases of metabolic homeostasis.Pflugers Arch. 2010 Jul;460(2):295-306. doi: 10.1007/s00424-009-0771-y. Epub 2009 Dec 24.
38 Expression of ADAMTS-1 mRNA in myocardium of viral heart disease mice and its clinical significance.Exp Ther Med. 2019 Jan;17(1):153-158. doi: 10.3892/etm.2018.6894. Epub 2018 Oct 25.
39 Determination of Agonistically Acting Autoantibodies to the Adrenergic Beta-1 Receptor by Cellular Bioassay.Methods Mol Biol. 2019;1901:95-102. doi: 10.1007/978-1-4939-8949-2_8.
40 Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGF1/Smad2/3 signaling axis.Chem Biol Interact. 2019 Apr 1;302:11-21. doi: 10.1016/j.cbi.2019.01.031. Epub 2019 Jan 29.
41 Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases.Adv Exp Med Biol. 2019;1193:155-174. doi: 10.1007/978-981-13-6260-6_9.
42 Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes.Toxicol Sci. 2012 Apr;126(2):298-305. doi: 10.1093/toxsci/kfr347. Epub 2012 Jan 18.
43 Apelin/APJ System: A Novel Therapeutic Target for Myocardial Ischemia/Reperfusion Injury.DNA Cell Biol. 2016 Dec;35(12):766-775. doi: 10.1089/dna.2016.3391. Epub 2016 Nov 17.
44 Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction.Clin Chem. 2005 Feb;51(2):360-7. doi: 10.1373/clinchem.2004.040477. Epub 2004 Dec 2.
45 Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes.Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2109-19. doi: 10.1152/ajpheart.00157.2009. Epub 2009 Oct 9.
46 Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury.Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
47 CD36 gene polymorphism is associated with Alzheimer's disease.Biochimie. 2017 Apr;135:46-53. doi: 10.1016/j.biochi.2017.01.009. Epub 2017 Jan 20.
48 CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy.Theranostics. 2018 Nov 15;8(21):5995-6007. doi: 10.7150/thno.27706. eCollection 2018.
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