General Information of Disease (ID: DISVS67S)

Disease Name Vascular disease
Synonyms vasculopathy; vasculature disease; disorder of vasculature; vasculature disease or disorder; disease or disorder of vasculature; vascular tissue disease; vascular disorder; disease of vasculature
Disease Class BE2Z: Circulatory system disease
Definition
A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome.|The etiology of vasculopathy is generally unknown and the condition is frequently not pathologically proven. Vasculitis, on the other hand, is a more specific term and is defined as inflammation of the wall of a blood vessel. However, the term vasculopathy is also used for vasculitis?that has not been pathologically established.
Disease Hierarchy
DISWD40R: Disease
DIS2IQDX: Cardiovascular disease
DISVS67S: Vascular disease
ICD Code
ICD-11
ICD-11: BE2Z
Disease Identifiers
MONDO ID
MONDO_0005385
MESH ID
D014652
UMLS CUI
C0042373
MedGen ID
22621
SNOMED CT ID
27550009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Iopanoic acid DMET18Q Approved Small molecular drug [1]
Oxilan iohexol DMKQF4U Approved NA [1]
Tolazoline DMI40NL Approved Small molecular drug [2]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Isoxsuprine DMURMY1 Withdrawn from market Small molecular drug [3]
RB-006 DMAINU1 Discontinued in Phase 3 NA [4]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
MV-2101 DMXDCJU Preclinical NA [5]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 4 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BTM-0512 DMSNLIK Investigative NA [6]
FP-1102 DMGID4T Investigative NA [7]
N-9xxx DMML1J4 Investigative NA [8]
VPC-94075 DM20AJ4 Investigative Small molecular drug [9]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 104 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCG1 TTMWDGU Limited Altered Expression [10]
ACVRL1 TTGYPTC Limited Genetic Variation [11]
ANGPT1 TTWNQ1T Limited Biomarker [12]
APLN TT87D3J Limited Altered Expression [13]
APOB TTN1IE2 Limited Biomarker [14]
CRP TTWRN6M Limited Genetic Variation [15]
ENG TTB30LE Limited Genetic Variation [16]
F3 TT38MDJ Limited Biomarker [17]
GPR182 TTT23CG Limited Biomarker [18]
NOTCH3 TTVX7IA Limited Biomarker [19]
NOX4 TTQRBSJ Limited Biomarker [20]
PPARD TT2JWF6 Limited Biomarker [21]
PPIA TTL2ADK Limited Altered Expression [22]
PREP TTNGKET Limited Biomarker [23]
SERPINE1 TTTO43N Limited Biomarker [24]
THBD TTAPV67 Limited Genetic Variation [25]
ADAM8 TTQWYMD moderate Biomarker [26]
APOH TT2OUI9 moderate Biomarker [27]
GDF2 TTAP4T1 moderate Genetic Variation [28]
SUV39H1 TTUWQTK moderate Altered Expression [29]
VKORC1 TTEUC8H moderate Genetic Variation [30]
VWF TT3SZBT moderate Biomarker [31]
ACE2 TTUI5H7 Strong Biomarker [32]
ADM TTV14YH Strong Biomarker [33]
ADM2 TTM642F Strong Therapeutic [34]
AGER TTMO9HF Strong Biomarker [35]
AHR TT037IE Strong Biomarker [36]
ALDH2 TTFLN4T Strong Biomarker [37]
AOC3 TT7HC21 Strong Biomarker [38]
APLNR TTJ8E43 Strong Biomarker [13]
APOC3 TTXOZQ1 Strong Genetic Variation [39]
BACE1 TTJUNZF Strong Altered Expression [40]
BGN TT0JPVF Strong Altered Expression [41]
CAPN2 TTG5QB7 Strong Biomarker [42]
CBL TT7QT13 Strong Genetic Variation [43]
CBS TTVZJ7G Strong Biomarker [44]
CDC20 TTBKFDV Strong Biomarker [45]
CDH5 TTXLCFO Strong Biomarker [46]
CFP TTLA0VS Strong Biomarker [47]
CPB2 TTP18AY Strong Biomarker [48]
CTH TTLQUZS Strong Biomarker [49]
CTSV TTSD9T1 Strong Altered Expression [50]
DKK2 TTST5KX Strong Biomarker [51]
DUSP5 TTZN92A Strong Biomarker [52]
EDN2 TTMR0OP Strong Genetic Variation [53]
EGFL7 TT7WD0H Strong Biomarker [54]
EGR1 TTE8LGD Strong Biomarker [55]
ENTPD1 TTYM8DJ Strong Altered Expression [56]
EPO TTQG4NR Strong Therapeutic [57]
F7 TTF0EGX Strong Genetic Variation [58]
FGF1 TTMY81X Strong Altered Expression [59]
FGF23 TT2IZ4K Strong Biomarker [60]
FGG TTR31L7 Strong Biomarker [61]
FOSL2 TT689IR Strong Altered Expression [62]
FURIN TTH9WF6 Strong Biomarker [63]
GCG TT6Y4PN Strong Biomarker [64]
GLA TTIS03D Strong Genetic Variation [65]
HBA2 TTQO71U Strong Biomarker [66]
HGF TT4V2JM Strong Therapeutic [67]
HTRA1 TT8POQR Strong Biomarker [68]
KLK8 TTH5MRS Strong Biomarker [69]
KLKB1 TTN0PCX Strong Biomarker [70]
LAMP2 TTULDG7 Strong Biomarker [71]
LDLR TTH0DUS Strong Genetic Variation [72]
LGALS3 TTFPQV7 Strong Biomarker [73]
LIPG TTHSZXO Strong Biomarker [74]
LTB4R TTN53ZF Strong Biomarker [75]
MAOB TTGP7BY Strong Altered Expression [76]
MAP2K5 TTV3O87 Strong Biomarker [77]
MAPK7 TTU6FSC Strong Biomarker [78]
MYLK TT18ETS Strong Biomarker [79]
NR3C2 TT26PHO Strong Biomarker [80]
OLR1 TTKSND3 Strong Biomarker [81]
OSM TTIVXSE Strong Biomarker [82]
P2RX1 TTJW7B3 Strong Biomarker [83]
P2RX3 TT2THBD Strong Biomarker [83]
PCSK9 TTNIZ2B Strong Biomarker [84]
PDE4A TTZ97H5 Strong Biomarker [85]
PDGFC TTOABM9 Strong Biomarker [86]
PDGFD TTSN0GA Strong Biomarker [86]
PKN1 TTSL41O Strong Biomarker [87]
PLA2G1B TT9V5JH Strong Biomarker [88]
PLA2G7 TTDNFMT Strong Biomarker [89]
PLG TTP86E2 Strong Biomarker [90]
PNP TTMCF1Y Strong Biomarker [91]
PTGIR TTOFYT1 Strong Genetic Variation [92]
PTPRB TT64I9Q Strong Biomarker [93]
REN TTB2MXP Strong Biomarker [94]
RHO TTH0KSX Strong Biomarker [95]
RPGR TTHBDA9 Strong Genetic Variation [96]
S1PR2 TTVSMOH Strong Biomarker [97]
SELE TT1PL7M Strong Biomarker [98]
SELP TTE5VG0 Strong Biomarker [99]
SGK1 TTTV8EJ Strong Biomarker [100]
SLC12A3 TTP362L Strong Biomarker [101]
SOD2 TT9O4C5 Strong Genetic Variation [102]
SORT1 TTRX9AV Strong Genetic Variation [103]
TEK TT9VGXW Strong Biomarker [104]
THBS1 TTKI0H1 Strong Biomarker [105]
TNFRSF11B TT2CJ75 Strong Biomarker [106]
TRPC1 TTA76X0 Strong Biomarker [107]
VEGFB TTPJQHE Strong Biomarker [108]
YY1AP1 TTYED1Q Strong Genetic Variation [109]
KCNN4 TT7M9I6 Definitive Genetic Variation [110]
------------------------------------------------------------------------------------
⏷ Show the Full List of 104 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC6 DT582KR Strong Genetic Variation [111]
------------------------------------------------------------------------------------
This Disease Is Related to 8 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ABO DESIA7R Limited Biomarker [112]
ACP5 DESITDW Limited Biomarker [113]
AOC2 DE8DP90 Strong Biomarker [38]
CYP4F2 DE3GT9C Strong Biomarker [114]
GGCT DEKW6PB Strong Genetic Variation [115]
MSRA DEU2ZBY Strong Biomarker [116]
PGPEP1 DEVDR46 Strong Biomarker [117]
SCLY DEH4TD6 Strong Biomarker [118]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DME(s)
This Disease Is Related to 123 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSL1 OTB06ESI Limited Biomarker [119]
COL4A1 OTL6D1YE Limited Genetic Variation [120]
CORT OTX3GUHB Limited Biomarker [121]
FLI1 OT0EV3LX Limited Biomarker [122]
GCA OTAJ7ZHG Limited Biomarker [123]
MGP OTZWU3FU Limited Genetic Variation [124]
SAMHD1 OTBCIBC7 Limited Genetic Variation [125]
SH2B2 OTEDHHDH Limited Biomarker [126]
SOX18 OTPUMHWA Limited Biomarker [127]
STING1 OTDAP4G0 Limited Genetic Variation [128]
THOC5 OTHY50SK Limited Biomarker [129]
TM7SF2 OTILU5S7 Limited Biomarker [12]
ESM1 OT331Y8V Disputed Altered Expression [130]
C1QTNF1 OT7I7KHC moderate Biomarker [131]
CUL9 OTPUCLZT moderate Altered Expression [132]
TET3 OT76U3YF moderate Biomarker [133]
ABCG8 OTIJ76XW Strong Genetic Variation [134]
ACTA2 OTEDLG8E Strong Biomarker [135]
ADA2 OTGCV24S Strong Altered Expression [136]
ADAMTS7 OTVKZ1DV Strong Biomarker [137]
ADCY9 OT1IZT5K Strong Genetic Variation [138]
ADGRB1 OTJSEXRC Strong Biomarker [139]
AGGF1 OTA7U2T8 Strong Genetic Variation [140]
ANGPT4 OT881M3K Strong Genetic Variation [141]
ANTXR1 OT5W1GPC Strong Biomarker [142]
APOA5 OTEVKLVA Strong Altered Expression [143]
APOM OTI3FQQC Strong Altered Expression [144]
ATOX1 OT05LF59 Strong Biomarker [145]
BGLAP OTK1YLWQ Strong Biomarker [146]
BRCC3 OTK0ZN7Y Strong Genetic Variation [147]
C1QL3 OT4TZH3J Strong Biomarker [148]
C1QTNF12 OTFAIQHR Strong Biomarker [149]
C1QTNF9 OTLI3VA3 Strong Biomarker [150]
CABIN1 OT4G5CIK Strong Biomarker [151]
CCDC88A OT3SSYYC Strong Biomarker [152]
CEBPZ OT11BATG Strong Biomarker [153]
CRB1 OTXYUNG0 Strong Genetic Variation [154]
CREG1 OTRHJ8HK Strong Biomarker [155]
CRISP2 OT8HLTV5 Strong Biomarker [105]
CTHRC1 OTV88X2G Strong Biomarker [156]
CXCL6 OTFTCQ4O Strong Biomarker [157]
CYBA OT16N9ZO Strong Altered Expression [158]
DCP1B OTX7PHCI Strong Genetic Variation [159]
DDB2 OTO8HVVB Strong Genetic Variation [160]
DDOST OT39PDMS Strong Biomarker [161]
DECR1 OTCDIR6X Strong Biomarker [162]
DLAT OT9LBJVN Strong Altered Expression [163]
DOCK6 OTPNUVLT Strong Genetic Variation [164]
DUOX1 OTQ2AEW0 Strong Altered Expression [165]
ECM1 OT1K65VW Strong Biomarker [166]
EFEMP2 OT0I2B4J Strong Biomarker [167]
EIF3E OTI0WG98 Strong Biomarker [168]
ENHO OT91QASK Strong Altered Expression [169]
FAM3A OTK1X62Z Strong Biomarker [170]
FBLN5 OTLVNZ8U Strong Biomarker [171]
FGA OTMIHY80 Strong Biomarker [61]
FGB OT6RKLI9 Strong Biomarker [61]
FLII OT7G9JG6 Strong Altered Expression [172]
FLVCR2 OTAM94ID Strong Genetic Variation [173]
GABPA OT9YB2SA Strong Biomarker [174]
GBP1 OTUM7RPJ Strong Altered Expression [175]
GEN1 OT1XFQXF Strong Biomarker [176]
H2AZ1 OT3KJJNQ Strong Biomarker [177]
HBA1 OTW2BQF4 Strong Biomarker [66]
HSPA6 OTH4S7WB Strong Altered Expression [178]
IFIH1 OTZA2AHA Strong Biomarker [179]
IKBKG OTNWJWSD Strong Biomarker [180]
ISYNA1 OT49ONSE Strong Biomarker [181]
KALRN OT8WRCBH Strong Biomarker [182]
KL OTD4VWU6 Strong Biomarker [183]
KLF15 OTGMQMVR Strong Biomarker [184]
LAD1 OT6YGTVX Strong Biomarker [185]
LIPC OTZY5SC9 Strong Genetic Variation [186]
LMO7 OTDLY6TC Strong Biomarker [187]
LOXL1 OTA0NEJU Strong Genetic Variation [188]
LPCAT3 OTWI96P4 Strong Biomarker [189]
LRP8 OTZ71YV2 Strong Biomarker [45]
MARCHF8 OTH7PNN2 Strong Genetic Variation [190]
MLXIP OT30UNI7 Strong Genetic Variation [190]
MMD OTB5I4OC Strong Biomarker [191]
MRTFA OTCVXASM Strong Biomarker [192]
MRTFB OT9OXGS9 Strong Biomarker [193]
MYH14 OT1TZEJK Strong Altered Expression [194]
MYL9 OT6B22JB Strong Biomarker [79]
MYLIP OTL0PFGV Strong Genetic Variation [190]
MYO1E OTM9YSIZ Strong Biomarker [195]
MYOCD OTSJNHTH Strong Biomarker [196]
ND5 OT45LW1K Strong Genetic Variation [197]
NDNF OTCDL9PG Strong Biomarker [198]
NDP OTGDJ4US Strong Genetic Variation [199]
NDUFV1 OTEVK4WW Strong Genetic Variation [197]
NEXN OTKB0B0H Strong Biomarker [200]
NLGN2 OTHDYL3H Strong Biomarker [201]
NOXA1 OTQDX9RY Strong Altered Expression [202]
OR10A4 OTYYB8SY Strong Genetic Variation [203]
P2RX2 OT0LF34A Strong Biomarker [83]
P2RX6 OT1FNTXA Strong Biomarker [83]
PF4V1 OT2CXM6L Strong Biomarker [204]
PHACTR1 OTAMPX9V Strong Genetic Variation [205]
PI3 OT47MTC3 Strong Altered Expression [206]
PKD2 OTIXBU8H Strong Biomarker [57]
PLXNA2 OTNNBJMQ Strong Biomarker [207]
POU2F3 OTIOOJWD Strong Genetic Variation [208]
PROCR OTRHED17 Strong Biomarker [98]
PRSS55 OTXXWI5Y Strong Biomarker [105]
RAB26 OTHMPRJK Strong Biomarker [209]
RAMP2 OTGQXLH5 Strong Biomarker [33]
RGS1 OTGXJYMG Strong Biomarker [210]
SCARA5 OTOVA96E Strong Biomarker [211]
SETD5 OTRPAVEO Strong Biomarker [212]
SORL1 OTQ8FFNS Strong Biomarker [213]
SPZ1 OTQH8HJ5 Strong Biomarker [105]
SYNPO2 OTC3U0YH Strong Biomarker [214]
TAS2R10 OT4RWZZD Strong Altered Expression [215]
TFEB OTJUJJQY Strong Biomarker [216]
TRAF3IP2 OTLLZERL Strong Biomarker [217]
TREX1 OTQG7K12 Strong Biomarker [218]
TRIB2 OTHSX3MX Strong Altered Expression [215]
ARF6 OTVV7KJO Definitive Biomarker [219]
CCL4L2 OTDBSXOU Definitive Biomarker [220]
EFNB3 OT12WTXQ Definitive Genetic Variation [221]
PTX3 OTPXHRKU Definitive Biomarker [222]
TIMP1 OTOXC51H Definitive Biomarker [223]
------------------------------------------------------------------------------------
⏷ Show the Full List of 123 DOT(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Tolazoline FDA Label
3 Prognostic value of initial blood viscosity on vascular surgery and treatment in peripheral disease. Angiology. 1981 Apr;32(4):230-5.
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019932)
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018857)
6 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767).
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613).
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6041).
10 Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.Circulation. 2008 May 27;117(21):2785-92. doi: 10.1161/CIRCULATIONAHA.107.741314. Epub 2008 May 19.
11 Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18940-5. doi: 10.1073/pnas.1310479110. Epub 2013 Oct 16.
12 Orchestral actions of angiopoietin-1 in vascular regeneration.Trends Mol Med. 2013 Jan;19(1):31-9. doi: 10.1016/j.molmed.2012.10.010. Epub 2012 Nov 23.
13 Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.J Clin Invest. 2020 Jan 2;130(1):94-107. doi: 10.1172/JCI128469.
14 Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice.Life Sci. 2009 Jun 19;84(25-26):935-9. doi: 10.1016/j.lfs.2009.04.011. Epub 2009 May 3.
15 Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study.Neurol Res. 2019 Dec;41(12):1090-1096. doi: 10.1080/01616412.2019.1673286. Epub 2019 Oct 4.
16 Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-.Front Med (Lausanne). 2019 Jan 30;6:10. doi: 10.3389/fmed.2019.00010. eCollection 2019.
17 Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells.Microvasc Res. 2008 Nov;76(3):152-60. doi: 10.1016/j.mvr.2008.07.007. Epub 2008 Aug 5.
18 Outcome of antibody-mediated rejection compared to acute cellular rejection after pediatric heart transplantation.Pediatr Transplant. 2018 Feb;22(1). doi: 10.1111/petr.13092. Epub 2017 Dec 9.
19 Human blood vessel organoids as amodel ofdiabetic vasculopathy.Nature. 2019 Jan;565(7740):505-510. doi: 10.1038/s41586-018-0858-8. Epub 2019 Jan 16.
20 Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.Clin Exp Ophthalmol. 2018 Aug;46(6):652-660. doi: 10.1111/ceo.13155. Epub 2018 Feb 23.
21 Ligand-activated PPAR inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS.PLoS One. 2019 Jan 8;14(1):e0210482. doi: 10.1371/journal.pone.0210482. eCollection 2019.
22 PPIA rs6850: A>G single-nucleotide polymorphism is associated with raised plasma cyclophilin A levels in patients with coronary artery disease.Mol Cell Biochem. 2016 Jan;412(1-2):259-68. doi: 10.1007/s11010-015-2632-7. Epub 2015 Dec 24.
23 Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.Free Radic Biol Med. 2017 Nov;112:376-386. doi: 10.1016/j.freeradbiomed.2017.08.004. Epub 2017 Aug 9.
24 Role of plasminogen activator inhibitor-1 in coronary pathophysiology.Thromb Res. 2018 Apr;164:54-62. doi: 10.1016/j.thromres.2018.02.135. Epub 2018 Feb 20.
25 Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children.Dis Markers. 2018 Jun 12;2018:1064380. doi: 10.1155/2018/1064380. eCollection 2018.
26 Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans.Atherosclerosis. 2019 Jul;286:163-171. doi: 10.1016/j.atherosclerosis.2019.03.008. Epub 2019 Mar 17.
27 APOH is increased in the plasma and liver of type 2 diabetic patients with metabolic syndrome.Atherosclerosis. 2010 Mar;209(1):201-5. doi: 10.1016/j.atherosclerosis.2009.09.072. Epub 2009 Oct 6.
28 Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension: a case report.BMC Pulm Med. 2016 Jan 22;16:17. doi: 10.1186/s12890-016-0183-7.
29 Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.Eur Heart J. 2019 Jan 21;40(4):383-391. doi: 10.1093/eurheartj/ehx615.
30 Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study.J Thromb Haemost. 2007 Oct;5(10):2020-4. doi: 10.1111/j.1538-7836.2007.02706.x.
31 Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.Blood. 2019 Apr 4;133(14):1597-1606. doi: 10.1182/blood-2018-10-881557. Epub 2019 Jan 28.
32 Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13006-13015. doi: 10.1073/pnas.1900152116. Epub 2019 Jun 12.
33 Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.Endocrinology. 2017 May 1;158(5):1359-1372. doi: 10.1210/en.2016-1531.
34 Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.Cardiovasc Res. 2010 Mar 1;85(4):864-73. doi: 10.1093/cvr/cvp366. Epub 2009 Nov 12.
35 Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-B signaling pathways.J Biomed Sci. 2019 Sep 6;26(1):68. doi: 10.1186/s12929-019-0550-9.
36 Association of serum aryl hydrocarbon receptor activity and RBC omega-3 polyunsaturated fatty acids with flow-mediated dilation in healthy, young Hispanic cigarette smokers.Toxicol Lett. 2015 Jan 22;232(2):422-8. doi: 10.1016/j.toxlet.2014.12.002. Epub 2014 Dec 4.
37 Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction.Cardiovasc Res. 2008 Nov 1;80(2):280-9. doi: 10.1093/cvr/cvn182. Epub 2008 Jul 2.
38 Cross-talk between A and endothelial SSAO/VAP-1 accelerates vascular damage and A aggregation related to CAA-AD.Neurobiol Aging. 2015 Feb;36(2):762-75. doi: 10.1016/j.neurobiolaging.2014.09.030. Epub 2014 Oct 13.
39 Apolipoprotein C-III: From Pathophysiology to Pharmacology.Trends Pharmacol Sci. 2015 Oct;36(10):675-687. doi: 10.1016/j.tips.2015.07.001.
40 Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1.Neurobiol Aging. 2009 Oct;30(10):1535-44. doi: 10.1016/j.neurobiolaging.2007.12.012. Epub 2008 Mar 4.
41 Atheroprotective remodelling of vascular dermatan sulphate proteoglycans in response to hypercholesterolaemia in a rat model.Int J Exp Pathol. 2014 Jun;95(3):181-90. doi: 10.1111/iep.12072. Epub 2014 Mar 7.
42 Redox Regulation of Calpains: Consequences on Vascular Function.Antioxid Redox Signal. 2019 Mar 1;30(7):1011-1026. doi: 10.1089/ars.2018.7607. Epub 2018 Nov 15.
43 De novo mutations in CBL causing early-onset paediatric moyamoya angiopathy.J Med Genet. 2017 Aug;54(8):550-557. doi: 10.1136/jmedgenet-2016-104432. Epub 2017 Mar 25.
44 Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice.Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):1954-1963. doi: 10.1167/iovs.16-21247.
45 ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury.Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2132-2144. doi: 10.1161/ATVBAHA.119.313194. Epub 2019 Aug 15.
46 In Development-A New Paradigm for Understanding Vascular Disease.J Cardiovasc Pharmacol. 2017 May;69(5):248-263. doi: 10.1097/FJC.0000000000000480.
47 The complement factor properdin induces formation of platelet-leukocyte aggregates via leukocyte activation.Platelets. 2008 Aug;19(5):359-64. doi: 10.1080/09537100802105040.
48 Identification of human thrombin-activatable fibrinolysis inhibitor in vascular and inflammatory cells.Thromb Haemost. 2011 Jun;105(6):999-1009. doi: 10.1160/TH10-06-0413. Epub 2011 Apr 20.
49 Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).Hum Genet. 2003 Apr;112(4):404-8. doi: 10.1007/s00439-003-0906-8. Epub 2003 Feb 6.
50 Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis.Rheumatology (Oxford). 2013 May;52(5):790-9. doi: 10.1093/rheumatology/kes379. Epub 2013 Jan 3.
51 Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury.Sci Rep. 2017 Dec 19;7(1):17819. doi: 10.1038/s41598-017-17862-5.
52 Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.BMC Biochem. 2017 May 31;18(1):10. doi: 10.1186/s12858-017-0083-3.
53 Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes.Clin Chem Lab Med. 2006;44(8):929-32. doi: 10.1515/CCLM.2006.180.
54 Epidermal Growth Factor Like-domain 7 and miR-126 are abnormally expressed in diffuse Systemic Sclerosis fibroblasts.Sci Rep. 2019 Mar 14;9(1):4589. doi: 10.1038/s41598-019-39485-8.
55 Involvement of the Akt-dependent CREB signaling pathway in hydrogen-peroxide-induced early growth response protein-1 expression in rat vascular smooth muscle cells (1).Can J Physiol Pharmacol. 2019 Sep;97(9):885-892. doi: 10.1139/cjpp-2019-0061. Epub 2019 Apr 2.
56 Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.Semin Thromb Hemost. 2005 Apr;31(2):217-33. doi: 10.1055/s-2005-869527.
57 Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration.PLoS One. 2014 Jul 11;9(7):e102013. doi: 10.1371/journal.pone.0102013. eCollection 2014.
58 Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction.N Engl J Med. 1998 Jan 8;338(2):79-85. doi: 10.1056/NEJM199801083380202.
59 Aqueous humour concentrations of TGF-, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy.Acta Ophthalmol. 2017 May;95(3):e206-e211. doi: 10.1111/aos.13230. Epub 2016 Sep 28.
60 Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD.BMC Nephrol. 2017 Sep 4;18(1):281. doi: 10.1186/s12882-017-0705-4.
61 Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease.Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1558-66. doi: 10.1161/01.ATV.0000136649.83297.bf. Epub 2004 Jun 24.
62 The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis.Arthritis Rheum. 2010 Jan;62(1):280-90. doi: 10.1002/art.25056.
63 Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.Mol Cell Biol. 2007 Apr;27(8):2997-3007. doi: 10.1128/MCB.01485-06. Epub 2007 Feb 5.
64 Treatment intensification strategies after initial metformin therapy in adult patients with type-2 diabetes: results of the DPV and DIVE registries.Acta Diabetol. 2020 Feb;57(2):229-236. doi: 10.1007/s00592-019-01409-3. Epub 2019 Aug 30.
65 High-risk screening for Anderson-Fabry disease in patients with cardiac, renal, or neurological manifestations.J Hum Genet. 2019 Sep;64(9):891-898. doi: 10.1038/s10038-019-0633-1. Epub 2019 Jun 19.
66 Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.Br J Haematol. 2012 Nov;159(3):352-9. doi: 10.1111/bjh.12034. Epub 2012 Sep 7.
67 Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. J Hum Hypertens. 2004 Oct;18(10):701-5. doi: 10.1038/sj.jhh.1001727.
68 BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.J Neurosci. 2018 Apr 11;38(15):3840-3857. doi: 10.1523/JNEUROSCI.2031-17.2018. Epub 2018 Feb 26.
69 Hypoglossal nerve paralysis in a child after a dental procedure.Neurol Neurochir Pol. 2018 May-Jun;52(3):406-409. doi: 10.1016/j.pjnns.2018.01.006. Epub 2018 Feb 6.
70 Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP.Biochimie. 2017 Apr;135:72-81. doi: 10.1016/j.biochi.2017.01.010. Epub 2017 Jan 20.
71 Small-Vessel Vasculopathy Due to Aberrant Autophagy in LAMP-2 Deficiency.Sci Rep. 2018 Feb 20;8(1):3326. doi: 10.1038/s41598-018-21602-8.
72 Cost-effectiveness of PCSK9 inhibition in addition to standard lipid-lowering therapy in patients at high risk for vascular disease.Int J Cardiol. 2018 Feb 15;253:148-154. doi: 10.1016/j.ijcard.2017.10.080.
73 Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.J Biochem Mol Toxicol. 2017 May;31(5). doi: 10.1002/jbt.21879. Epub 2016 Nov 21.
74 Flow-mediated dilation, carotid wall thickness and HDL function in subjects with hyperalphalipoproteinemia.Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):777-83. doi: 10.1016/j.numecd.2014.02.010. Epub 2014 Mar 1.
75 Inhibited aortic aneurysm formation in BLT1-deficient mice.J Immunol. 2007 Jul 1;179(1):691-7. doi: 10.4049/jimmunol.179.1.691.
76 Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta.Hypertension. 2013 Jul;62(1):140-6. doi: 10.1161/HYPERTENSIONAHA.113.01314. Epub 2013 May 13.
77 Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).J Biol Chem. 2010 Aug 20;285(34):26199-210. doi: 10.1074/jbc.M110.103127. Epub 2010 Jun 15.
78 Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells.PLoS One. 2017 May 22;12(5):e0178278. doi: 10.1371/journal.pone.0178278. eCollection 2017.
79 Regulation of myosin light chain kinase expression by angiotensin II in hypertension.Am J Hypertens. 2008 Aug;21(8):860-5. doi: 10.1038/ajh.2008.199. Epub 2008 May 29.
80 Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy.Cell Mol Neurobiol. 2019 May;39(4):483-492. doi: 10.1007/s10571-018-0610-9. Epub 2018 Aug 16.
81 Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.Ann N Y Acad Sci. 2019 May;1443(1):34-53. doi: 10.1111/nyas.13984. Epub 2018 Nov 1.
82 In vivo affinity and target engagement in skin and blood in a first-time-in-human study of an anti-oncostatin M monoclonal antibody.Br J Clin Pharmacol. 2018 Oct;84(10):2280-2291. doi: 10.1111/bcp.13669. Epub 2018 Jul 12.
83 P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.J Clin Invest. 2018 Aug 1;128(8):3490-3503. doi: 10.1172/JCI94524. Epub 2018 Jul 16.
84 Treatment of hypercholesterolaemia with PCSK9 inhibitors in patients after cardiac transplantation.PLoS One. 2019 Jan 16;14(1):e0210373. doi: 10.1371/journal.pone.0210373. eCollection 2019.
85 Roflumilast inhibits leukocyte-platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes.J Thromb Haemost. 2016 Jan;14(1):191-204. doi: 10.1111/jth.13173. Epub 2015 Dec 8.
86 PDGF-C and PDGF-D signaling in vascular diseases and animal models. Mol Aspects Med. 2018 Aug;62:1-11.
87 Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.J Biol Chem. 2012 Oct 19;287(43):36291-304. doi: 10.1074/jbc.M112.361220. Epub 2012 Aug 13.
88 Phospholipase A(2) in vascular disease.Circ Res. 2001 Aug 17;89(4):298-304. doi: 10.1161/hh1601.095598.
89 Lp-PLA2 as a promising predictor of comorbidities in patients with severe psoriasis.J Dermatolog Treat. 2020 Aug;31(5):524-530. doi: 10.1080/09546634.2019.1606887. Epub 2019 May 15.
90 Plasma plasmin-2-plasmin inhibitor complex levels may predict the effect of cyclophosphamide for systemic sclerosis-related interstitial lung disease.Mod Rheumatol. 2017 Jul;27(4):618-622. doi: 10.1080/14397595.2016.1226472. Epub 2016 Sep 13.
91 Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.Pulm Circ. 2018 Jul-Sep;8(3):2045894018791557. doi: 10.1177/2045894018791557. Epub 2018 Jul 13.
92 Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.Pharmacogenet Genomics. 2008 Jul;18(7):611-20. doi: 10.1097/FPC.0b013e328301a774.
93 Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.Clin Sci (Lond). 2017 Jan 1;131(1):87-103. doi: 10.1042/CS20160129.
94 Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice.Clin Sci (Lond). 2019 Mar 1;133(5):629-643. doi: 10.1042/CS20180547. Print 2019 Mar 15.
95 p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.J Biol Chem. 2017 Aug 25;292(34):14080-14091. doi: 10.1074/jbc.M117.777896. Epub 2017 Jun 27.
96 A novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa and Coats'-like exudative vasculopathy.Am J Ophthalmol. 2006 Jan;141(1):208-10. doi: 10.1016/j.ajo.2005.07.077.
97 Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.Blood. 2013 Jul 18;122(3):443-55. doi: 10.1182/blood-2012-11-467191. Epub 2013 May 30.
98 Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.Kidney Int. 2005 Jul;68(1):110-20. doi: 10.1111/j.1523-1755.2005.00385.x.
99 Sodium Sulfite Exacerbates Allograft Vasculopathy and Affects Tryptophan Breakdown in Murine Heterotopic Aortic Transplantation.Oxid Med Cell Longev. 2019 Apr 8;2019:8461048. doi: 10.1155/2019/8461048. eCollection 2019.
100 SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation.Anal Cell Pathol (Amst). 2019 Nov 13;2019:3013765. doi: 10.1155/2019/3013765. eCollection 2019.
101 Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25.
102 ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels.Gene. 2017 Sep 5;627:57-62. doi: 10.1016/j.gene.2017.05.055. Epub 2017 May 25.
103 LDL-c-linked SNPs are associated with LDL-c and myocardial infarction despite lipid-lowering therapy in patients with established vascular disease.Eur J Clin Invest. 2014 Feb;44(2):184-91. doi: 10.1111/eci.12206. Epub 2013 Dec 16.
104 Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF- (Transforming Growth Factor-)-Dependent Pulmonary Arterial Hypertension.Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202. doi: 10.1161/ATVBAHA.118.312038.
105 Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20.
106 The Role of Osteoprotegerin and Its Ligands in Vascular Function.Int J Mol Sci. 2019 Feb 6;20(3):705. doi: 10.3390/ijms20030705.
107 TRPC1 stimulates calciumsensing receptorinduced storeoperated Ca2+ entry and nitric oxide production in endothelial cells.Mol Med Rep. 2017 Oct;16(4):4613-4619. doi: 10.3892/mmr.2017.7164. Epub 2017 Aug 4.
108 Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases.Growth Factors. 2018 Apr;36(1-2):48-57. doi: 10.1080/08977194.2018.1477140. Epub 2018 Jul 3.
109 Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease. Am J Hum Genet. 2017 Jan 5;100(1):21-30. doi: 10.1016/j.ajhg.2016.11.008. Epub 2016 Dec 8.
110 Relationship between haplotypes of KCNN4 gene and susceptibility to human vascular diseases in Japanese.Med Sci Monit. 2009 Aug;15(8):CR389-97.
111 Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease.Circ Cardiovasc Genet. 2011 Oct;4(5):534-41. doi: 10.1161/CIRCGENETICS.110.958801. Epub 2011 Aug 10.
112 Does the heart transplant have a future?.Eur J Cardiothorac Surg. 2019 Jun 1;55(Suppl 1):i38-i48. doi: 10.1093/ejcts/ezz107.
113 Tartrate-Resistant Acid Phosphatase 5b in Young Patients With Sickle Cell Disease and Trait Siblings: Relation to Vasculopathy and Bone Mineral Density.Clin Appl Thromb Hemost. 2017 Jan;23(1):64-71. doi: 10.1177/1076029615594001. Epub 2015 Jul 6.
114 Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25.
115 5'UTR repeat polymorphisms of the BMPR2 gene in children with pulmonary hypertension associated with congenital heart disease.Heart Lung Circ. 2013 Mar;22(3):204-10. doi: 10.1016/j.hlc.2012.09.004. Epub 2012 Oct 24.
116 Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2594-604. doi: 10.1161/ATVBAHA.115.305857. Epub 2015 Oct 8.
117 Prostacyclin in vascular diseases. - Recent insights and future perspectives -.Circ J. 2010 May;74(5):836-43. doi: 10.1253/circj.cj-10-0195. Epub 2010 Apr 15.
118 Moyamoya vasculopathy with anti-SCL-70 antibodies: A case report and review of the literature.J Clin Neurosci. 2018 Oct;56:177-179. doi: 10.1016/j.jocn.2018.06.055. Epub 2018 Jul 13.
119 Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E715-24. doi: 10.1073/pnas.1111600109. Epub 2012 Jan 17.
120 Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders.Headache. 2017 Apr;57(4):537-569. doi: 10.1111/head.13053. Epub 2017 Mar 8.
121 Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.Circ Res. 2013 May 24;112(11):1444-55. doi: 10.1161/CIRCRESAHA.112.300695. Epub 2013 Apr 17.
122 Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy.J Invest Dermatol. 2019 May;139(5):1150-1160. doi: 10.1016/j.jid.2018.11.016. Epub 2018 Nov 30.
123 Cardiovascular risk factors associated with polymyalgia rheumatica and giant cell arteritis in a prospective cohort: EPIC-Norfolk Study.Rheumatology (Oxford). 2020 Feb 1;59(2):319-323. doi: 10.1093/rheumatology/kez289.
124 Serum total matrix Gla protein: Reference interval in healthy adults and variations in patients with vascular and osteoarticular diseases.Clin Chim Acta. 2019 Mar;490:128-134. doi: 10.1016/j.cca.2018.12.029. Epub 2018 Dec 28.
125 Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation.Clin Rheumatol. 2017 Jun;36(6):1445-1451. doi: 10.1007/s10067-017-3600-2. Epub 2017 Mar 13.
126 Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome.Rheumatology (Oxford). 2018 Jul 1;57(7):1228-1234. doi: 10.1093/rheumatology/key067.
127 R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma.Elife. 2019 Jul 30;8:e43026. doi: 10.7554/eLife.43026.
128 Baricitinib experience on STING-associated vasculopathy with onset in infancy: A representative case from Turkey.Clin Immunol. 2020 Mar;212:108273. doi: 10.1016/j.clim.2019.108273. Epub 2019 Oct 15.
129 THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision.Circ Res. 2018 Aug 17;123(5):538-549. doi: 10.1161/CIRCRESAHA.118.313527.
130 Analysis of Serum Endothelial Cell-Specific Molecule 1 (Endocan) Level in Type 2 Diabetes Mellitus With Acute ST-Segment Elevation Myocardial Infarction and its Correlation: A Pilot Study.Angiology. 2017 Jan;68(1):74-78. doi: 10.1177/0003319716634581. Epub 2016 Feb 28.
131 Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1.Clin Kidney J. 2018 Oct 11;12(3):420-426. doi: 10.1093/ckj/sfy095. eCollection 2019 Jun.
132 Vascular disease in COPD: Systemic and pulmonary expression of PARC (Pulmonary and Activation-Regulated Chemokine).PLoS One. 2017 May 18;12(5):e0177218. doi: 10.1371/journal.pone.0177218. eCollection 2017.
133 Reduced mRNA and Protein Expression Levels of Tet Methylcytosine Dioxygenase 3 in Endothelial Progenitor Cells of Patients of Type 2 Diabetes With Peripheral Artery Disease.Front Immunol. 2018 Dec 6;9:2859. doi: 10.3389/fimmu.2018.02859. eCollection 2018.
134 Frequencies of four ATP-binding cassette transporter G8 polymorphisms in patients with ischemic vascular diseases.Genet Test Mol Biomarkers. 2010 Oct;14(5):667-72. doi: 10.1089/gtmb.2010.0035. Epub 2010 Sep 20.
135 European reference network for rare vascular diseases (VASCERN) consensus statement for the screening and management of patients with pathogenic ACTA2 variants.Orphanet J Rare Dis. 2019 Nov 21;14(1):264. doi: 10.1186/s13023-019-1186-2.
136 What's new in autoinflammation?.Pediatr Nephrol. 2019 Dec;34(12):2449-2456. doi: 10.1007/s00467-018-4155-4. Epub 2018 Dec 14.
137 Upregulation of ADAMTS? and downregulation of COMP are associated with aortic aneurysm.Mol Med Rep. 2017 Oct;16(4):5459-5463. doi: 10.3892/mmr.2017.7293. Epub 2017 Aug 21.
138 ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.JAMA Cardiol. 2018 May 1;3(5):401-408. doi: 10.1001/jamacardio.2018.0569.
139 A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40kDa vasculostatin from tumor suppressor BAI1.Oncogene. 2012 Dec 13;31(50):5144-52. doi: 10.1038/onc.2012.1. Epub 2012 Feb 13.
140 Is the E133K allele of VG5Q associated with Klippel-Trenaunay and other overgrowth syndromes?.J Med Genet. 2006 Jul;43(7):613-4. doi: 10.1136/jmg.2006.040790. Epub 2006 Jan 27.
141 Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia.J Hum Genet. 2010 Oct;55(10):649-55. doi: 10.1038/jhg.2010.79. Epub 2010 Jul 1.
142 Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia.PLoS One. 2016 Jan 19;11(1):e0146586. doi: 10.1371/journal.pone.0146586. eCollection 2016.
143 Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease.PLoS One. 2014 Jun 30;9(6):e101082. doi: 10.1371/journal.pone.0101082. eCollection 2014.
144 Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression.J Atheroscler Thromb. 2017 Sep 1;24(9):954-969. doi: 10.5551/jat.37663. Epub 2017 Mar 17.
145 Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13. doi: 10.1161/ATVBAHA.112.300862. Epub 2013 Jan 24.
146 Potential Role for Osteocalcin in the Development of Atherosclerosis and Blood Vessel Disease.Nutrients. 2018 Oct 4;10(10):1426. doi: 10.3390/nu10101426.
147 Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya.Am J Hum Genet. 2011 Jun 10;88(6):718-728. doi: 10.1016/j.ajhg.2011.04.017. Epub 2011 May 19.
148 CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes.Diabetes. 2020 Jan;69(1):99-111. doi: 10.2337/db19-0635. Epub 2019 Nov 1.
149 Adipolin/CTRP12 protects against pathological vascular remodelling through suppression of smooth muscle cell growth and macrophage inflammatory response.Cardiovasc Res. 2020 Jan 1;116(1):237-249. doi: 10.1093/cvr/cvz074.
150 C1q/TNF-related protein 9: A novel therapeutic target in ischemic stroke?.J Neurosci Res. 2019 Feb;97(2):128-136. doi: 10.1002/jnr.24353. Epub 2018 Oct 31.
151 Everolimus Use for Intolerance or Failure of Baseline Immunosuppression in Adult Heart and Lung Transplantation.Ann Transplant. 2018 Oct 23;23:744-750. doi: 10.12659/AOT.910952.
152 Angiotensin II facilitates neointimal formation by increasing vascular smooth muscle cell migration: Involvement of APE/Ref-1-mediated overexpression of sphingosine-1-phosphate receptor 1.Toxicol Appl Pharmacol. 2018 May 15;347:45-53. doi: 10.1016/j.taap.2018.03.032. Epub 2018 Mar 30.
153 Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Tc-99m HM-PAO single photon emission computed tomography.Neuroradiology. 1990;32(2):142-5. doi: 10.1007/BF00588564.
154 The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.Hum Mol Genet. 2015 Jan 1;24(1):128-41. doi: 10.1093/hmg/ddu424. Epub 2014 Aug 21.
155 Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):485-494. doi: 10.1161/ATVBAHA.116.308794. Epub 2017 Jan 5.
156 The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling.Trends Cardiovasc Med. 2007 Aug;17(6):202-5. doi: 10.1016/j.tcm.2007.05.004.
157 Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.J Rheumatol. 2017 Aug;44(8):1198-1205. doi: 10.3899/jrheum.161092. Epub 2017 May 15.
158 Endothelial nitric oxide synthase and nicotinamide adenosine dinucleotide phosphate oxidase p22phox gene (C242T) polymorphisms and systemic lupus erythematosus in a Chinese Population.Lupus. 2010 Feb;19(2):192-6. doi: 10.1177/0961203309348980. Epub 2009 Dec 4.
159 Genes related to vascular disease (APOE, VLDL-R, DCP-1) and other vascular factors in late-life depression.Am J Geriatr Psychiatry. 2004 Mar-Apr;12(2):202-10.
160 Nucleotide excision DNA repair is associated with age-related vascular dysfunction.Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15.
161 AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.Am J Physiol Cell Physiol. 2010 Mar;298(3):C624-34. doi: 10.1152/ajpcell.00463.2009. Epub 2009 Dec 2.
162 p22phox promotes Ang-II-induced vascular smooth muscle cell phenotypic switch by regulating KLF4 expression.Biochem Biophys Res Commun. 2019 Jun 18;514(1):280-286. doi: 10.1016/j.bbrc.2019.04.128. Epub 2019 Apr 26.
163 Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients.Rheumatology (Oxford). 2006 Jun;45(6):694-702. doi: 10.1093/rheumatology/kei244. Epub 2006 Jan 17.
164 Diffuse angiopathy in Adams-Oliver syndrome associated with truncating DOCK6 mutations.Am J Med Genet A. 2014 Oct;164A(10):2656-62. doi: 10.1002/ajmg.a.36685. Epub 2014 Aug 4.
165 Oxidative/nitrative stress in the pathogenesis of systemic sclerosis: are antioxidants beneficial?.Free Radic Res. 2018 Oct;52(10):1063-1082. doi: 10.1080/10715762.2018.1525712. Epub 2018 Nov 13.
166 Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hum Mol Genet. 2002 Apr 1;11(7):833-40. doi: 10.1093/hmg/11.7.833.
167 Imaging findings in a distinct lethal inherited arteriopathy syndrome associated with a novel mutation in the FBLN4 gene.Eur Radiol. 2014 Aug;24(8):1742-8. doi: 10.1007/s00330-014-3205-y. Epub 2014 May 17.
168 The Bad, the Good and eIF3e/INT6.Front Biosci (Landmark Ed). 2017 Jan 1;22(1):1-20. doi: 10.2741/4469.
169 Serum adropin level and ENHO gene expression in systemic sclerosis.Clin Rheumatol. 2016 Jun;35(6):1535-40. doi: 10.1007/s10067-016-3266-1. Epub 2016 Apr 15.
170 Endothelial FAM3A positively regulates post-ischaemic angiogenesis.EBioMedicine. 2019 May;43:32-42. doi: 10.1016/j.ebiom.2019.03.038. Epub 2019 Apr 16.
171 Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa.Hum Mol Genet. 2002 Sep 1;11(18):2113-8. doi: 10.1093/hmg/11.18.2113.
172 Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli-1-knockout mice by increasing Fli-1 DNA binding ability.Arthritis Rheumatol. 2015 May;67(5):1335-44. doi: 10.1002/art.39062.
173 High-throughput sequencing of a 4.1Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy.Hum Mutat. 2010 Oct;31(10):1134-41. doi: 10.1002/humu.21329.
174 Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy.Am J Transplant. 2020 May;20(5):1262-1271. doi: 10.1111/ajt.15724. Epub 2020 Jan 3.
175 The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.EMBO J. 2001 Oct 15;20(20):5568-77. doi: 10.1093/emboj/20.20.5568.
176 GEN-O-MA project: an Italian network studying clinical course and pathogenic pathways of moyamoya disease-study protocol and preliminary results.Neurol Sci. 2019 Mar;40(3):561-570. doi: 10.1007/s10072-018-3664-z. Epub 2019 Jan 3.
177 Histone Variant H2A.Z Is Required for the Maintenance of Smooth Muscle Cell Identity as Revealed by Single-Cell Transcriptomics.Circulation. 2018 Nov 13;138(20):2274-2288. doi: 10.1161/CIRCULATIONAHA.117.033114.
178 HSP70 is associated with endothelial activation in placental vascular diseases.Mol Med. 2008 Sep-Oct;14(9-10):561-6. doi: 10.2119/2008-00009.Liu.
179 The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients.Rheumatology (Oxford). 2019 May 1;58(5):786-791. doi: 10.1093/rheumatology/key386.
180 Retinal vascular changes of incontinentia pigmenti.Arch Ophthalmol. 1976 May;94(5):743-6. doi: 10.1001/archopht.1976.03910030353001.
181 Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions.J Pharm Pharmacol. 2008 Aug;60(8):999-1017. doi: 10.1211/jpp.60.8.0007.
182 Kalirin: a novel genetic risk factor for ischemic stroke.Hum Genet. 2010 Mar;127(5):513-23. doi: 10.1007/s00439-010-0790-y. Epub 2010 Jan 28.
183 Plasma Klotho concentrations predict functional outcome at three months after acute ischemic stroke patients.Ann Med. 2019 May-Jun;51(3-4):262-269. doi: 10.1080/07853890.2019.1617434. Epub 2019 Jun 5.
184 Kruppel-like factor 15 is critical for vascular inflammation.J Clin Invest. 2013 Oct;123(10):4232-41. doi: 10.1172/JCI68552. Epub 2013 Sep 3.
185 Intravascular ultrasound of the proximal left anterior descending artery is sufficient to detect early cardiac allograft vasculopathy.Clin Transplant. 2018 Feb;32(2). doi: 10.1111/ctr.13167. Epub 2017 Dec 14.
186 Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels.Kidney Int. 2003 Nov;64(5):1829-37. doi: 10.1046/j.1523-1755.2003.00285.x.
187 LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor Signaling and Fibrosis.Circulation. 2019 Jan 29;139(5):679-693. doi: 10.1161/CIRCULATIONAHA.118.034615.
188 LOXL1 gene sequence variants and vascular disease in exfoliation syndrome and exfoliative glaucoma.J Glaucoma. 2011 Mar;20(3):143-7. doi: 10.1097/IJG.0b013e3181d9d8dd.
189 Association between the C3F gene and atherosclerotic vascular diseases.Hum Hered. 1975;25(4):279-83. doi: 10.1159/000152736.
190 Associations of MicroRNA Polymorphisms (miR-146a, miR-196a2, and miR-499) with the Risk of Hypertension in the Korean Population.Genet Test Mol Biomarkers. 2016 Aug;20(8):420-6. doi: 10.1089/gtmb.2016.0039. Epub 2016 Jul 5.
191 Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.Am J Hum Genet. 2009 May;84(5):617-27. doi: 10.1016/j.ajhg.2009.04.007. Epub 2009 Apr 30.
192 Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.J Biol Chem. 2012 Aug 10;287(33):28067-77. doi: 10.1074/jbc.M112.379487. Epub 2012 Jun 20.
193 Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.J Biol Chem. 2007 Dec 21;282(51):37244-55. doi: 10.1074/jbc.M708137200. Epub 2007 Oct 17.
194 Myosin gene expression and cell phenotypes in vascular smooth muscle during development, in experimental models, and in vascular disease.Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1210-5. doi: 10.1161/01.atv.17.7.1210.
195 Exosomes from mesenchymal stem cells expressing miR-125b inhibit neointimal hyperplasia via myosin IE.J Cell Mol Med. 2019 Feb;23(2):1528-1540. doi: 10.1111/jcmm.14060. Epub 2018 Nov 28.
196 Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):817-28. doi: 10.1161/ATVBAHA.114.305218. Epub 2015 Jan 22.
197 Outcome of epilepsy in patients with mitochondrial disorders: Phenotype genotype and magnetic resonance imaging correlations.Clin Neurol Neurosurg. 2018 Jan;164:182-189. doi: 10.1016/j.clineuro.2017.12.010. Epub 2017 Dec 9.
198 Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.J Biol Chem. 2014 May 16;289(20):14132-44. doi: 10.1074/jbc.M114.555789. Epub 2014 Apr 6.
199 A novel NDP mutation in an infant with unilateral persistent fetal vasculature and retinal vasculopathy.Ophthalmic Genet. 2009 Jun;30(2):99-102. doi: 10.1080/13816810802705755.
200 NEXN is a novel susceptibility gene for coronary artery disease in Han Chinese.PLoS One. 2013 Dec 11;8(12):e82135. doi: 10.1371/journal.pone.0082135. eCollection 2013.
201 Modulation of Angiopoietin 2 release from endothelial cells and angiogenesis by the synaptic protein Neuroligin 2.Biochem Biophys Res Commun. 2018 Jun 18;501(1):165-171. doi: 10.1016/j.bbrc.2018.04.204. Epub 2018 May 4.
202 Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.Circulation. 2010 Feb 2;121(4):549-59. doi: 10.1161/CIRCULATIONAHA.109.908319. Epub 2010 Jan 18.
203 Haptoglobin Genotype Is a Determinant of Hemoglobin Adducts and Vitamin E Content in HDL.J Diabetes Res. 2018 May 20;2018:6125420. doi: 10.1155/2018/6125420. eCollection 2018.
204 Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.Circ Res. 2004 Oct 29;95(9):855-7. doi: 10.1161/01.RES.0000146674.38319.07. Epub 2004 Sep 30.
205 A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.Cell. 2017 Jul 27;170(3):522-533.e15. doi: 10.1016/j.cell.2017.06.049.
206 A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.J Eur Acad Dermatol Venereol. 2019 Apr;33(4):753-760. doi: 10.1111/jdv.15387. Epub 2019 Jan 1.
207 An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography.J Biophotonics. 2018 Feb;11(2). doi: 10.1002/jbio.201600312. Epub 2017 Aug 8.
208 Platelet glycoprotein receptor IIIa polymorphism PLA1/PLA2 and coronary risk: a meta-analysis.Thromb Haemost. 2001 Apr;85(4):626-33.
209 Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells.Theranostics. 2017 Jun 25;7(9):2537-2554. doi: 10.7150/thno.17584. eCollection 2017.
210 RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.Nat Commun. 2015 Mar 18;6:6614. doi: 10.1038/ncomms7614.
211 Knockdown of SCARA5 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of the PDGF signaling pathway.Mol Med Rep. 2016 May;13(5):4455-60. doi: 10.3892/mmr.2016.5074. Epub 2016 Mar 30.
212 The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.Genet Med. 2020 Feb;22(2):427-431. doi: 10.1038/s41436-019-0639-2. Epub 2019 Sep 2.
213 Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.Arch Neurol. 2008 Dec;65(12):1640-8. doi: 10.1001/archneur.65.12.1640.
214 Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1489-97. doi: 10.1161/ATVBAHA.114.305065. Epub 2015 Apr 9.
215 Tribbles-2 is a novel regulator of inflammatory activation of monocytes.Int Immunol. 2008 Dec;20(12):1543-50. doi: 10.1093/intimm/dxn116. Epub 2008 Oct 24.
216 Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet.Cell Death Dis. 2019 Sep 12;10(9):676. doi: 10.1038/s41419-019-1931-4.
217 TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H52-H64. doi: 10.1152/ajpheart.00478.2017. Epub 2017 Sep 29.
218 Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation.J Neuropathol Exp Neurol. 2019 Feb 1;78(2):181-186. doi: 10.1093/jnen/nly115.
219 Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.J Clin Invest. 2017 Dec 1;127(12):4569-4582. doi: 10.1172/JCI91770. Epub 2017 Oct 23.
220 Inhibition of macrophage inflammatory protein-1 improves endothelial progenitor cell function and ischemia-induced angiogenesis in diabetes.Angiogenesis. 2019 Feb;22(1):53-65. doi: 10.1007/s10456-018-9636-3. Epub 2018 Jul 9.
221 Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene.Sci Rep. 2017 Mar 8;7:44114. doi: 10.1038/srep44114.
222 Circulating pentraxin 3 is positively associated with chronic hyperglycemia but negatively associated with plasma aldosterone concentration.PLoS One. 2018 May 1;13(5):e0196526. doi: 10.1371/journal.pone.0196526. eCollection 2018.
223 Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker.Toxicol Sci. 2007 Nov;100(1):238-47. doi: 10.1093/toxsci/kfm161. Epub 2007 Jun 14.