Details of Disease

General Information of Disease (ID: DISW4TQ8)

• Disease Name: Wolff-Parkinson-White syndrome
• Synonyms: accessory atrioventricular pathways; preexcitation syndrome; Wpw syndrome; Wolff-Parkinson-White pattern; anomalous atrioventricular excitation; Wolff-Parkinson-White pattern (finding); Wolff-Parkinson-White syndrome; Wolff-Parkinson-white syndrome (disease); anomalous A-V excitation; WPW; ventricular familial preexcitation syndrome
• Definition: A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes.
• Disease Hierarchy:
  DIS5DQIA: PRKAG2-related cardiomyopathy
  DISLKUNL: Heart arrhythmia
  DISW4TQ8: Wolff-Parkinson-White syndrome
• Disease Identifiers:
  MONDO ID: MONDO_0008685
  MESH ID: D014927
  UMLS CUI: C0043202
  OMIM ID: 194200
  MedGen ID: 12162
  HPO ID: HP:0001716
  Orphanet ID: 907
  SNOMED CT ID: 74390002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BMP2	TTP3IGX	Limited	Biomarker	[1]
LAMP2	TTULDG7	Limited	Genetic Variation	[2]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
APRT	DE2MV1R	Strong	Genetic Variation	[3]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MYH6	OT3YNCH1	moderate	Genetic Variation	[4]
ND5	OT45LW1K	moderate	Genetic Variation	[5]
MFAP1	OTZN4FT3	Strong	Genetic Variation	[3]
PRKAG2	OTHTAM54	Strong	Autosomal dominant	[6]
PRKAG3	OTS1A2VE	Strong	Genetic Variation	[7]

References

• [1] A 8.26Mb deletion in 6q16 and a 4.95Mb deletion in 20p12 including JAG1 and BMP2 in a patient with Alagille syndrome and Wolff-Parkinson-White syndrome.Eur J Med Genet. 2008 Nov-Dec;51(6):651-7. doi: 10.1016/j.ejmg.2008.07.012. Epub 2008 Aug 15.
• [2] Danon disease as an underrecognized cause of hypertrophic cardiomyopathy in children.Circulation. 2005 Sep 13;112(11):1612-7. doi: 10.1161/CIRCULATIONAHA.105.546481. Epub 2005 Sep 6.
• [3] Overexpression of G100S mutation in PRKAG2 causes Wolff-Parkinson-White syndrome in zebrafish.Clin Genet. 2014 Sep;86(3):287-91. doi: 10.1111/cge.12267. Epub 2013 Oct 25.
• [4] Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus.Am J Med Genet A. 2015 Dec;167A(12):2975-84. doi: 10.1002/ajmg.a.37297. Epub 2015 Aug 18.
• [5] Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy.Pediatr Neonatol. 2008 Aug;49(4):145-9. doi: 10.1016/S1875-9572(08)60030-3.
• [6] The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
• [7] PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population.J Chin Med Assoc. 2016 Dec;79(12):656-660. doi: 10.1016/j.jcma.2016.08.008. Epub 2016 Nov 17.