Details of Disease

General Information of Disease (ID: DISYEEY6)

• Disease Name: Dyspepsia
• Synonyms: indigestion; dyspepsia, indigestion
• Disease Class: MD92: Dyspepsia
• Definition: An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.
• Disease Hierarchy:
  DISGJGHR: Functional gastric disease
  DISYEEY6: Dyspepsia
• ICD Code:
  ICD-11: ICD-11: MD92
  ICD-9: ICD-9: 536.8
  Expand ICD-11: 'MD92
  Expand ICD-9: 536.8
• Disease Identifiers:
  MONDO ID: MONDO_0002268
  MESH ID: D004415
  UMLS CUI: C0013395
  MedGen ID: 41681
  HPO ID: HP:0410281
  SNOMED CT ID: 162031009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bromopride	DMYSJRN	Approved	Small molecular drug	[1]
Simethicone	DMXQRU1	Approved	Small molecular drug	[1]
Tegaserod	DM3XYD1	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GTP-010	DMN6IDO	Phase 2	NA	[3]
IW-9179	DM3OKTP	Phase 2	NA	[4]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AJA-777	DM41FCK	Discontinued in Phase 2	NA	[5]
FR-208419	DMLG426	Terminated	Small molecular drug	[7]

This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TZP-202	DMRGZQA	Preclinical	NA	[6]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DW-953	DMEHOFF	Investigative	NA	[8]
NG-049	DMTKSJ0	Investigative	NA	[8]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CRH	TTA7YIZ	Limited	Biomarker	[9]
S100A8	TT4AF6N	moderate	Biomarker	[10]
CYSLTR2	TT0PZR5	Strong	Altered Expression	[11]
HTR3A	TTPC4TU	Strong	Genetic Variation	[12]
PPY	TTIB95A	Strong	Biomarker	[13]
SCN10A	TT90XZ8	Strong	Genetic Variation	[14]
SLC6A4	TT3ROYC	Strong	Genetic Variation	[15]
SSTR3	TTJX3UE	Strong	Altered Expression	[16]
TRPV1	TTMI6F5	Strong	Genetic Variation	[17]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
UGT1A9	DE85D2P	Strong	Biomarker	[18]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KCNIP3	OTCQPEM4	Disputed	Biomarker	[19]
SYMPK	OTYAUDXV	Disputed	Biomarker	[19]
AGA	OTNWT1WB	Strong	Biomarker	[20]
CELA3B	OTGU8BE9	Strong	Biomarker	[21]
CTBP1	OTVYH2DH	Strong	Biomarker	[22]
GNB3	OTA6HYBA	Strong	Genetic Variation	[23]
PRLHR	OT1THGOP	Strong	Genetic Variation	[24]
MCM5	OTAHLB62	Definitive	Altered Expression	[25]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 226).
• [3] Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
• [4] ClinicalTrials.gov (NCT02289846) Trial of IW-9179 in Patients With Diabetic Gastroparesis (DGP). U.S. National Institutes of Health.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034308)
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023009)
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010485)
• [8] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [9] Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults.PLoS One. 2011 May 12;6(5):e19498. doi: 10.1371/journal.pone.0019498.
• [10] Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey.Braz J Microbiol. 2014 Mar 10;44(4):1267-74. doi: 10.1590/s1517-83822013000400034. eCollection 2013 Dec.
• [11] Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study.BMC Gastroenterol. 2016 Jul 30;16(1):85. doi: 10.1186/s12876-016-0499-z.
• [12] Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia.BMC Med Genet. 2011 Oct 20;12:140. doi: 10.1186/1471-2350-12-140.
• [13] Utility of the plasma pancreatic polypeptide response to modified sham feeding in diabetic gastroenteropathy and non-ulcer dyspepsia.Neurogastroenterol Motil. 2020 Feb;32(2):e13744. doi: 10.1111/nmo.13744. Epub 2019 Oct 22.
• [14] Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects.J Gastroenterol. 2013 Jan;48(1):73-80. doi: 10.1007/s00535-012-0602-3. Epub 2012 May 23.
• [15] Polymorphisms of 5-HTT LPR and GN3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.Am J Gastroenterol. 2017 Jun;112(6):903-909. doi: 10.1038/ajg.2017.52. Epub 2017 Mar 14.
• [16] Influence of cigarette smoking on the level of mRNA of somatostatin receptor 3 (SSTR3) in the gastric mucosa of patients with functional dyspepsia.Adv Med Sci. 2010;55(1):53-8. doi: 10.2478/v10039-010-0026-3.
• [17] Functional dyspepsia susceptibility is related to CD14, GNB3, MIF, and TRPV1 gene polymorphisms in the Greek population.Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12913. Epub 2016 Jul 19.
• [18] Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.Transpl Immunol. 2013 Dec;29(1-4):155-61. doi: 10.1016/j.trim.2013.05.005. Epub 2013 May 27.
• [19] Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study).Neurogastroenterol Motil. 2018 Jul;30(7):e13319. doi: 10.1111/nmo.13319. Epub 2018 Mar 2.
• [20] White Paper AGA: Functional Dyspepsia.Clin Gastroenterol Hepatol. 2017 Aug;15(8):1191-1194. doi: 10.1016/j.cgh.2017.05.013. Epub 2017 May 18.
• [21] Association of Low Fecal Elastase-1 and Non-Ulcer Dyspepsia.J Clin Med. 2018 Jun 16;7(6):155. doi: 10.3390/jcm7060155.
• [22] Structural elucidation and bioactivities of a novel arabinogalactan from Coreopsis tinctoria.Carbohydr Polym. 2019 Sep 1;219:219-228. doi: 10.1016/j.carbpol.2019.05.019. Epub 2019 May 7.
• [23] G protein 3 subunit polymorphism and long-term prognosis of functional dyspepsia.Gut Liver. 2014 May;8(3):271-6. doi: 10.5009/gnl.2014.8.3.271.
• [24] Incidence of infusion hypersensitivity reaction after withholding dexamethasone premedication in early breast cancer patients not experiencing two previous cycles of infusion hypersensitivity reaction for weekly paclitaxel chemotherapy.Support Care Cancer. 2018 Jul;26(7):2471-2477. doi: 10.1007/s00520-018-4087-3. Epub 2018 Feb 12.
• [25] Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates.Br J Cancer. 2004 Aug 16;91(4):714-9. doi: 10.1038/sj.bjc.6602028.