Details of Disease

General Information of Disease (ID: DISYMCOF)

Disease Name Large cell carcinoma
Synonyms carcinoma, large cell; large cell carcinoma
Definition A malignant epithelial neoplasm composed of large, atypical cells.
Disease Hierarchy
DISH9F1N: Carcinoma
DISYMCOF: Large cell carcinoma
Disease Identifiers
MONDO ID
MONDO_0005232
MESH ID
D018287
UMLS CUI
C0206704
MedGen ID
61665
SNOMED CT ID
22687000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
STK33 TTP34DQ Limited Altered Expression [1]
CYP2A6 TTAQ6ZW Strong Biomarker [2]
CLDN6 TTKSV48 Definitive Genetic Variation [3]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
GLDC DEIN8FB Limited Biomarker [4]
ME1 DE97WM8 Strong Genetic Variation [5]
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This Disease Is Related to 7 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ERBIN OTNWTUA8 Limited Genetic Variation [6]
SPRR1B OTXNW3P6 Limited Altered Expression [7]
TMPO OTL68EL4 Limited Genetic Variation [6]
CHL1 OT6E6E8P Strong Altered Expression [8]
MKS1 OT83W5PB Strong Genetic Variation [5]
SFTPB OTOHS07E Strong Altered Expression [9]
PYCARD OT67RON3 Definitive Genetic Variation [10]
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⏷ Show the Full List of 7 DOT(s)

References

1 Correlation between STK33 and the pathology and prognosis of lung cancer.Oncol Lett. 2017 Oct;14(4):4800-4804. doi: 10.3892/ol.2017.6766. Epub 2017 Aug 17.
2 CYP2A6 overexpression in human lung cancers correlates with a high malignant status.Oncol Rep. 2007 Jul;18(1):53-7.
3 Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.Int J Cancer. 2014 Nov 1;135(9):2206-14. doi: 10.1002/ijc.28857. Epub 2014 Apr 8.
4 Glycine decarboxylase and HIF-1 expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer.Virchows Arch. 2017 Mar;470(3):323-330. doi: 10.1007/s00428-016-2057-z. Epub 2017 Jan 7.
5 Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmic reticulum stress-mediated mechanism.Acta Pharmacol Sin. 2017 Apr;38(4):539-550. doi: 10.1038/aps.2016.146. Epub 2017 Jan 23.
6 Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma.Virchows Arch. 2019 Oct;475(4):407-414. doi: 10.1007/s00428-019-02597-7. Epub 2019 Jun 15.
7 Mechanism of repression of squamous differentiation marker, SPRR1B, in malignant bronchial epithelial cells: role of critical TRE-sites and its transacting factors.Oncogene. 2001 Feb 1;20(5):634-44. doi: 10.1038/sj.onc.1204134.
8 Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).J Cancer Res Clin Oncol. 2019 Sep;145(9):2285-2292. doi: 10.1007/s00432-019-02989-x. Epub 2019 Aug 1.
9 Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles.PLoS One. 2016 Jun 20;11(6):e0157865. doi: 10.1371/journal.pone.0157865. eCollection 2016.
10 Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.Cancer Res. 2006 Jun 15;66(12):6210-8. doi: 10.1158/0008-5472.CAN-05-4447.