Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1DE2QT)

• DOT Name: Synaptosomal-associated protein 47 (SNAP47)
• Synonyms: SNAP-47; Epididymis luminal protein 170; Synaptosomal-associated 47 kDa protein
• Gene Name: SNAP47
• Related Disease:
  Colorectal carcinoma
  Hyperglycemia
  Non-small-cell lung cancer
  Prediabetes syndrome
  Proliferative diabetic retinopathy
  Type-1/2 diabetes
  X-linked reticulate pigmentary disorder
• UniProt ID: SNP47_HUMAN
• Pfam ID: PF02893
• Sequence:
  MRAARRGLHCAGAERPRRRGRLWDSSGVPQRQKRPGPWRTQTQEQMSRDVCIHTWPCTYY
  LEPKRRWVTGQLSLTSLSLRFMTDSTGEILVSFPLSSIVEIKKEASHFIFSSITILEKGH
  AKHWFSSLRPSRNVVFSIIEHFWRELLLSQPGAVADASVPRTRGEELTGLMAGSQKRLED
  TARVLHHQGQQLDSVMRGLDKMESDLEVADRLLTELESPAWWPFSSKLWKTPPETKPRED
  VSMTSCEPFGKEGILIKIPAVISHRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDV
  DDIKVHSPYEISIRQRFIGKPDMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSAR
  TSSPAEKSCSVWHAASGLMGRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRR
  MKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT
• Function: Plays a role in intracellular membrane fusion.

Molecular Interaction Atlas (MIA) of This DOT

7 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Colorectal carcinoma	DIS5PYL0	Strong	Biomarker	[1]
Hyperglycemia	DIS0BZB5	Strong	Biomarker	[2]
Non-small-cell lung cancer	DIS5Y6R9	Strong	Altered Expression	[3]
Prediabetes syndrome	DISH2I53	Strong	Biomarker	[2]
Proliferative diabetic retinopathy	DISQZ13G	Strong	Biomarker	[4]
Type-1/2 diabetes	DISIUHAP	Strong	Biomarker	[2]
X-linked reticulate pigmentary disorder	DIS0RB5A	Strong	Biomarker	[4]

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Cisplatin	DMRHGI9	Approved	Synaptosomal-associated protein 47 (SNAP47) decreases the response to substance of Cisplatin.	[9]

3 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Synaptosomal-associated protein 47 (SNAP47).	[5]
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide decreases the expression of Synaptosomal-associated protein 47 (SNAP47).	[6]
Leflunomide	DMR8ONJ	Phase 1 Trial	Leflunomide decreases the expression of Synaptosomal-associated protein 47 (SNAP47).	[8]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Synaptosomal-associated protein 47 (SNAP47).	[7]

References

• [1] Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.BMC Cancer. 2016 Feb 24;16:154. doi: 10.1186/s12885-016-2183-7.
• [2] Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively.Int J Obes (Lond). 2019 Mar;43(3):512-522. doi: 10.1038/s41366-018-0172-4. Epub 2018 Jul 18.
• [3] Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential.J Investig Med. 2012 Apr;60(4):689-94. doi: 10.2310/JIM.0b013e31824963b6.
• [4] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.Invest Ophthalmol Vis Sci. 2012 Jun 26;53(7):4055-62. doi: 10.1167/iovs.12-9857.
• [5] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [6] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [7] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [8] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [9] Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway. Environ Toxicol. 2022 Feb;37(2):224-236. doi: 10.1002/tox.23391. Epub 2021 Oct 19.