Details of Disease

General Information of Disease (ID: DISQZ13G)

• Disease Name: Proliferative diabetic retinopathy
• Disease Class: 9B71: Retinopathy
• Definition: Advanced retinopathy due to diabetes mellitus characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.
• Disease Hierarchy:
  DISHGUJM: Diabetic retinopathy
  DISQZ13G: Proliferative diabetic retinopathy
• ICD Code:
  ICD-11: ICD-11: 9B71.01
  Expand ICD-11: '9B71.01
• Disease Identifiers:
  MONDO ID: MONDO_0001660
  UMLS CUI: C0154830
  MedGen ID: 56347
  SNOMED CT ID: 59276001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Emixustat	DMH8VMP	Phase 2/3	Small molecular drug	[1]
OC-10X	DMOSRFZ	Phase 1	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 17 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD96	TT83C4X	Limited	Genetic Variation	[2]
CPM	TTVOH2M	Limited	Genetic Variation	[2]
DPP10	TTOVUPC	Limited	Genetic Variation	[2]
KCNN3	TT9JH25	Limited	Genetic Variation	[2]
NPY2R	TTJ6WK9	Limited	Genetic Variation	[3]
AMD1	TTBFROQ	Strong	Biomarker	[4]
AOC3	TT7HC21	Strong	Biomarker	[5]
CNTF	TTGEM5Q	Strong	Altered Expression	[6]
CTSH	TT3G406	Strong	Genetic Variation	[7]
DPEP1	TTYUENF	Strong	Biomarker	[8]
IL11RA	TTZPLJS	Strong	Biomarker	[9]
IL31	TT1RJXK	Strong	Altered Expression	[10]
PGF	TT48I1Y	Strong	Biomarker	[11]
PLXDC1	TTPSK7A	Strong	Biomarker	[12]
ROBO1	TTND1YP	Strong	Altered Expression	[13]
ROBO4	TT3S9TY	Strong	Biomarker	[14]
SLIT2	TTDWK85	Strong	Biomarker	[13]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC16A7	DTLT3UG	Limited	Genetic Variation	[2]
ABCC11	DTWN7FC	Strong	Biomarker	[15]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
AOC2	DE8DP90	Strong	Biomarker	[5]

This Disease Is Related to 22 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C1orf94	OTITUS83	Limited	Genetic Variation	[2]
CEP135	OT1O9XYJ	Limited	Genetic Variation	[3]
COMMD1	OT7WUD5R	Limited	Genetic Variation	[2]
GPATCH2	OT09TY4W	Limited	Genetic Variation	[2]
NAALADL2	OT2HOGPQ	Limited	Genetic Variation	[2]
OC90	OT7K2WV8	Limited	Genetic Variation	[2]
PRKAG2	OTHTAM54	Limited	Genetic Variation	[2]
STUM	OTORRHZ9	Limited	Genetic Variation	[2]
HYOU1	OTBGBSOV	moderate	Biomarker	[16]
ANGPTL8	OTQFINCD	Strong	Biomarker	[17]
ATP1A3	OTM8EG6H	Strong	Biomarker	[8]
C1QTNF3	OTOJMWW0	Strong	Biomarker	[18]
C1QTNF5	OTLKU5I2	Strong	Biomarker	[18]
CAPN5	OTQ8QM7K	Strong	Biomarker	[19]
ENHO	OT91QASK	Strong	Biomarker	[20]
IL26	OT2WYCW4	Strong	Altered Expression	[21]
MFRP	OTHY9ZA5	Strong	Biomarker	[18]
NELFE	OTL4E94L	Strong	Biomarker	[8]
PIWIL4	OTDA9MY0	Strong	Biomarker	[22]
PLXNA2	OTNNBJMQ	Strong	Genetic Variation	[23]
RPE	OT0XT3JU	Strong	Biomarker	[24]
SNAP47	OT1DE2QT	Strong	Biomarker	[25]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.Diabetes. 2019 Feb;68(2):441-456. doi: 10.2337/db18-0567. Epub 2018 Nov 28.
• [3] The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.Med Sci Monit. 2018 Dec 8;24:8891-8898. doi: 10.12659/MSM.909803.
• [4] Indocyanine green molecular angiography of choroidal neovascularization.Exp Eye Res. 2019 Mar;180:122-128. doi: 10.1016/j.exer.2018.12.016. Epub 2018 Dec 21.
• [5] Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy.Curr Eye Res. 2017 Dec;42(12):1674-1683. doi: 10.1080/02713683.2017.1359847. Epub 2017 Sep 22.
• [6] Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy.Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5594-5603. doi: 10.1167/iovs.17-21973.
• [7] Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).Graefes Arch Clin Exp Ophthalmol. 2015 Nov;253(11):1959-65. doi: 10.1007/s00417-015-3118-8. Epub 2015 Aug 6.
• [8] Retinal Nonperfusion Characteristics on Ultra-Widefield Angiography in Eyes With Severe Nonproliferative Diabetic Retinopathy and Proliferative Diabetic Retinopathy.JAMA Ophthalmol. 2019 Jun 1;137(6):626-631. doi: 10.1001/jamaophthalmol.2019.0440.
• [9] Interleukin-11 Overexpression and M2 Macrophage Density are Associated with Angiogenic Activity in Proliferative Diabetic Retinopathy.Ocul Immunol Inflamm. 2020 May 18;28(4):575-588. doi: 10.1080/09273948.2019.1616772. Epub 2019 Aug 12.
• [10] Association between aqueous humor and vitreous fluid levels of Th17 cell-related cytokines in patients with proliferative diabetic retinopathy.PLoS One. 2017 May 30;12(5):e0178230. doi: 10.1371/journal.pone.0178230. eCollection 2017.
• [11] Angiogenic and inflammatory biomarker levels in aqueous humor and vitreous of neovascular glaucoma and proliferative diabetic retinopathy.Int Ophthalmol. 2020 Feb;40(2):467-475. doi: 10.1007/s10792-019-01207-4. Epub 2019 Dec 4.
• [12] TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy.Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3151-7. doi: 10.1167/iovs.07-1249. Epub 2008 Mar 3.
• [13] The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy.PLoS One. 2017 Oct 3;12(10):e0185795. doi: 10.1371/journal.pone.0185795. eCollection 2017.
• [14] Upregulated VEGF and Robo4 correlate with the reduction of miR-15a in the development of diabetic retinopathy.Endocrine. 2019 Jul;65(1):35-45. doi: 10.1007/s12020-019-01921-0. Epub 2019 Apr 12.
• [15] Myeloid-Related Protein-14/MRP-14/S100A9/Calgranulin B is Associated with Inflammation in Proliferative Diabetic Retinopathy.Ocul Immunol Inflamm. 2018;26(4):615-624. doi: 10.1080/09273948.2016.1245759. Epub 2016 Nov 16.
• [16] The 150-kDa oxygen-regulated protein (ORP150) regulates proteinuria in diabetic nephropathy via mediating VEGF.Exp Mol Pathol. 2019 Oct;110:104255. doi: 10.1016/j.yexmp.2019.04.014. Epub 2019 Apr 25.
• [17] Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy.Int J Ophthalmol. 2017 Dec 18;10(12):1819-1823. doi: 10.18240/ijo.2017.12.05. eCollection 2017.
• [18] CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner.PLoS One. 2017 Jun 20;12(6):e0178253. doi: 10.1371/journal.pone.0178253. eCollection 2017.
• [19] Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.Sci Rep. 2019 May 20;9(1):7608. doi: 10.1038/s41598-019-44031-7.
• [20] The association of serum and vitreous adropin concentrations with diabetic retinopathy.Ann Clin Biochem. 2019 Mar;56(2):253-258. doi: 10.1177/0004563218820359. Epub 2019 Feb 24.
• [21] Increased interleukin-26 expression in proliferative diabetic retinopathy.Int J Ophthalmol. 2019 Nov 18;12(11):1688-1692. doi: 10.18240/ijo.2019.11.04. eCollection 2019.
• [22] PIWI-like protein, HIWI2: A novel player in proliferative diabetic retinopathy.Exp Eye Res. 2018 Dec;177:191-196. doi: 10.1016/j.exer.2018.08.018. Epub 2018 Aug 23.
• [23] Improved Macular Capillary Flow on Optical Coherence Tomography Angiography After Panretinal Photocoagulation for Proliferative Diabetic Retinopathy.Am J Ophthalmol. 2019 Oct;206:217-227. doi: 10.1016/j.ajo.2019.04.032. Epub 2019 May 10.
• [24] miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy.Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E443-E452. doi: 10.1152/ajpendo.00360.2018. Epub 2018 Dec 21.
• [25] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.Invest Ophthalmol Vis Sci. 2012 Jun 26;53(7):4055-62. doi: 10.1167/iovs.12-9857.