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Hydrochlorothiazide FDA Label
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Losartan FDA Label
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Prediabetes defined by the International Expert Committee as a risk for development of glomerular hyperfiltration.Acta Diabetol. 2019 May;56(5):525-529. doi: 10.1007/s00592-019-01287-9. Epub 2019 Feb 1.
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Magnificamide, a -Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian -Amylases.Mar Drugs. 2019 Sep 21;17(10):542. doi: 10.3390/md17100542.
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Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes.J Clin Med. 2019 Aug 14;8(8):1214. doi: 10.3390/jcm8081214.
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Carotid intima-media thickness values are significantly higher in patients with prediabetes compared to normal glucose metabolism.Medicine (Baltimore). 2019 Nov;98(44):e17805. doi: 10.1097/MD.0000000000017805.
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Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity.Molecules. 2018 Jun 19;23(6):1483. doi: 10.3390/molecules23061483.
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Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice.Diabetes. 1999 Mar;48(3):469-77. doi: 10.2337/diabetes.48.3.469.
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GAD65 as a potential marker for cognitive performance in an adult population with prediabetes.QJM. 2020 Feb 1;113(2):108-114. doi: 10.1093/qjmed/hcz239.
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Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance.Endocr J. 2017 Apr 29;64(4):403-410. doi: 10.1507/endocrj.EJ16-0472. Epub 2017 Feb 17.
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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.PLoS One. 2008;3(12):e3962. doi: 10.1371/journal.pone.0003962. Epub 2008 Dec 17.
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A Mixed-Methods, Randomized Clinical Trial to Examine Feasibility of a Mindfulness-Based Stress Management and Diabetes Risk Reduction Intervention for African Americans with Prediabetes.Evid Based Complement Alternat Med. 2019 Aug 14;2019:3962623. doi: 10.1155/2019/3962623. eCollection 2019.
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Elevated circulating Neuregulin4 level in patients with diabetes.Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2870. Epub 2016 Dec 27.
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Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again.J Clin Invest. 2004 Nov;114(10):1414-7. doi: 10.1172/JCI23586.
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PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.J Gastrointestin Liver Dis. 2019 Dec 9;28(4):433-438. doi: 10.15403/jgld-506.
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Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.
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Stronger associations of waist circumference and waist-to-height ratio with diabetes than BMI in Chinese adults.Diabetes Res Clin Pract. 2019 Jan;147:9-18. doi: 10.1016/j.diabres.2018.07.029. Epub 2018 Aug 23.
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Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease.Horm Res Paediatr. 2016;86(2):100-105. doi: 10.1159/000448003. Epub 2016 Aug 3.
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Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men.Diabetes Metab J. 2020 Apr;44(2):326-335. doi: 10.4093/dmj.2019.0031. Epub 2019 Oct 31.
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Glycation of glucose sensitive lysine residues K36, K438 and K549 of albumin is associated with prediabetes.J Proteomics. 2019 Sep 30;208:103481. doi: 10.1016/j.jprot.2019.103481. Epub 2019 Aug 5.
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Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats.Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
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Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes.Auton Neurosci. 2009 Mar 12;146(1-2):76-80. doi: 10.1016/j.autneu.2008.11.016. Epub 2009 Jan 17.
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Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis.Neurogastroenterol Motil. 2019 Apr;31(4):e13554. doi: 10.1111/nmo.13554. Epub 2019 Jan 22.
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10-year trajectory of -cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study.Lancet Diabetes Endocrinol. 2016 Jan;4(1):27-34. doi: 10.1016/S2213-8587(15)00336-8. Epub 2015 Nov 11.
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GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice.Peptides. 2020 Mar;125:170207. doi: 10.1016/j.peptides.2019.170207. Epub 2019 Nov 22.
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HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.PLoS Med. 2015 Jul 14;12(7):e1001853. doi: 10.1371/journal.pmed.1001853. eCollection 2015 Jul.
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Prediabetes is associated with genetic variations in the gene encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channel (KCNJ11): A case-control study in a Han Chinese youth population.J Diabetes. 2018 Feb;10(2):121-129. doi: 10.1111/1753-0407.12565. Epub 2017 Aug 1.
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Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes.Atherosclerosis. 2020 Jan;293:49-56. doi: 10.1016/j.atherosclerosis.2019.11.027. Epub 2019 Nov 28.
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Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-Up From a Community-Based Cohort.J Clin Endocrinol Metab. 2020 Mar 1;105(3):e381-9. doi: 10.1210/clinem/dgz171.
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Pre-diabetes alters testicular PGC1-/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress.Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
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The potential role of the osteopontin-osteocalcin-osteoprotegerin triad in the pathogenesis of prediabetes in humans.Acta Diabetol. 2018 Feb;55(2):139-148. doi: 10.1007/s00592-017-1065-z. Epub 2017 Nov 18.
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DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats.Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31. doi: 10.1016/s0006-291x(03)00409-1.
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UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China.BMC Med Genet. 2018 Mar 12;19(1):43. doi: 10.1186/s12881-018-0554-4.
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Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis.J Membr Biol. 2013 Dec;246(12):877-83. doi: 10.1007/s00232-013-9601-4. Epub 2013 Oct 9.
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Recent advances in biosensor technology in assessment of early diabetes biomarkers.Biosens Bioelectron. 2018 Jan 15;99:122-135. doi: 10.1016/j.bios.2017.07.047. Epub 2017 Jul 19.
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Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.PLoS One. 2018 Dec 10;13(12):e0208596. doi: 10.1371/journal.pone.0208596. eCollection 2018.
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Myonectin Predicts the Development of Type 2 Diabetes.J Clin Endocrinol Metab. 2018 Jan 1;103(1):139-147. doi: 10.1210/jc.2017-01604.
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Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis.Diabetologia. 2019 May;62(5):860-872. doi: 10.1007/s00125-019-4828-y. Epub 2019 Feb 18.
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Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.J Clin Endocrinol Metab. 2018 Sep 1;103(9):3278-3288. doi: 10.1210/jc.2018-00295.
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Common variants in PERK, JNK, BIP and XBP1 genes are associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population.Chin Med J (Engl). 2014;127(13):2438-44.
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Habitual coffee intake, genetic polymorphisms, and type 2 diabetes.Eur J Endocrinol. 2015 May;172(5):595-601. doi: 10.1530/EJE-14-0805. Epub 2015 Mar 9.
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Impact of short-term exercise training intensity on -cell function in older obese adults with prediabetes.J Appl Physiol (1985). 2018 Dec 1;125(6):1979-1986. doi: 10.1152/japplphysiol.00680.2018. Epub 2018 Oct 11.
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Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES).Lancet Diabetes Endocrinol. 2018 Oct;6(10):781-789. doi: 10.1016/S2213-8587(18)30234-1. Epub 2018 Sep 14.
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Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules.Arch Physiol Biochem. 2020 Oct;126(4):335-340. doi: 10.1080/13813455.2018.1538248. Epub 2018 Nov 21.
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Decreased transcription of ChREBP-/ isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia.Diabetes. 2013 Mar;62(3):837-44. doi: 10.2337/db12-0889. Epub 2012 Dec 3.
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HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.J Immunol. 2004 Mar 15;172(6):3955-62. doi: 10.4049/jimmunol.172.6.3955.
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Prediabetes is Characterized by Higher FGF23 Levels and Higher Prevalence of Vitamin D Deficiency Compared to Normal Glucose Tolerance Subjects.Horm Metab Res. 2019 Feb;51(2):106-111. doi: 10.1055/a-0813-3164. Epub 2018 Dec 20.
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Plasma Secretagogin is Increased in Individuals with Glucose Dysregulation.Exp Clin Endocrinol Diabetes. 2021 Sep;129(9):661-665. doi: 10.1055/a-1001-2244. Epub 2019 Sep 23.
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Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes.Sci Rep. 2019 Jul 1;9(1):9454. doi: 10.1038/s41598-019-46006-0.
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Reduced proliferation and a high apoptotic frequency of pancreatic beta cells contribute to genetically-determined diabetes susceptibility of db/db BKS mice.Horm Metab Res. 2011 May;43(5):306-11. doi: 10.1055/s-0031-1271817. Epub 2011 Mar 16.
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Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes.Diabetes Care. 2016 Nov;39(11):1889-1895. doi: 10.2337/dc16-0769. Epub 2016 Aug 25.
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The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works as Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes.J Pharmacol Exp Ther. 2017 Jul;362(1):24-30. doi: 10.1124/jpet.117.241281. Epub 2017 Apr 24.
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CILP-2 is a novel secreted protein and associated with insulin resistance.J Mol Cell Biol. 2019 Dec 19;11(12):1083-1094. doi: 10.1093/jmcb/mjz016.
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Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.Heart Vessels. 2020 Jan;35(1):52-58. doi: 10.1007/s00380-019-01453-7. Epub 2019 Jun 21.
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Relationship between serum osteocalcin/undercarboxylated osteocalcin and type 2 diabetes: a systematic review/meta-analysis study protocol.BMJ Open. 2019 Mar 12;9(3):e023918. doi: 10.1136/bmjopen-2018-023918.
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Protective Effects of an Obesity-Associated Polymorphism (CDKAL1 rs9356744) on Prediabetes: The Cardiometabolic Risk in Chinese (CRC) Study.Exp Clin Endocrinol Diabetes. 2018 Sep;126(9):540-545. doi: 10.1055/s-0042-109607. Epub 2018 Jun 22.
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Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.PLoS One. 2014 Jan 20;9(1):e84770. doi: 10.1371/journal.pone.0084770. eCollection 2014.
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Elevated mRNA levels of major histocompatibility complex class II genes in lymphocytes of autoimmune BB rats.Diabetes. 1988 Dec;37(12):1637-40. doi: 10.2337/diab.37.12.1637.
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Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress.Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H927-H943. doi: 10.1152/ajpheart.00049.2016. Epub 2016 Aug 12.
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The MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes.Gene. 2014 Aug 10;546(2):150-5. doi: 10.1016/j.gene.2014.06.028. Epub 2014 Jun 14.
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Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.Pancreas. 2000 Jan;20(1):47-54. doi: 10.1097/00006676-200001000-00007.
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Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively.Int J Obes (Lond). 2019 Mar;43(3):512-522. doi: 10.1038/s41366-018-0172-4. Epub 2018 Jul 18.
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