Details of the Drug Combination

General Information of Drug Combination (ID: DCTNGRL)

Drug Combination Name
ABT-263 Cytarabine
Indication
Disease Entry Status REF
Ewing sarcoma Investigative [1]
Component Drugs ABT-263   DMNE56X Cytarabine   DMZD5QR
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: TC-71
Zero Interaction Potency (ZIP) Score: 19.959
Bliss Independence Score: 20.359
Loewe Additivity Score: 10.415
LHighest Single Agent (HSA) Score: 13.239

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABT-263
Disease Entry ICD 11 Status REF
Myelofibrosis 2A20.2 Phase 3 [2]
Relapsed or refractory chronic lymphocytic leukaemia 2A82.0 Phase 2 [3]
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [4]
ABT-263 Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Apoptosis regulator Bcl-W (BCL-W) TTQ79W8 B2CL2_HUMAN Inhibitor [7]
G1/S-specific cyclin-D1 (CCND1) TTFCJ7S CCND1_HUMAN Inhibitor [8]
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Inhibitor [7]
Apoptosis regulator Bcl-xL (BCL-xL) TTU1E82 B2CL1_HUMAN Inhibitor [7]
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ABT-263 Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]
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ABT-263 Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [10]
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ABT-263 Interacts with 6 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [11]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Increases Cleavage [12]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [11]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [12]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [12]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Affects Response To Substance [11]
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⏷ Show the Full List of 6 DOT(s)
Indication(s) of Cytarabine
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [5]
Acute myelogenous leukaemia 2A41 Approved [6]
Adult acute monocytic leukemia N.A. Approved [6]
Childhood acute megakaryoblastic leukemia N.A. Approved [6]
Plasma cell myeloma 2A83.1 Approved [6]
Neoplastic meningitis N.A. Investigative [6]
Cytarabine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [20]
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Cytarabine Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [21]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [22]
Organic cation/carnitine transporter 1 (SLC22A4) DT2EG60 S22A4_HUMAN Substrate [23]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [24]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [24]
Equilibrative nucleoside transporter 2 (SLC29A2) DTW78DQ S29A2_HUMAN Substrate [24]
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⏷ Show the Full List of 6 DTP(s)
Cytarabine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [25]
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [26]
Ecto-5'-nucleotidase (NT5E) DE3Z9HM 5NTD_HUMAN Metabolism [26]
Deoxycytidylate deaminase (DCTD) DEXL3P2 DCTD_HUMAN Metabolism [26]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [27]
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Cytarabine Interacts with 549 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [28]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Decreases Response To Substance [29]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Increases Expression [13]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Increases Expression [13]
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) OTIFVXWD PDE6D_HUMAN Decreases Expression [13]
Lymphocyte antigen 75 (LY75) OTDHBU0N LY75_HUMAN Increases Expression [13]
ATP-dependent DNA helicase Q5 (RECQL5) OTVZMP1Q RECQ5_HUMAN Decreases Expression [13]
SLIT and NTRK-like protein 5 (SLITRK5) OTTSUSB8 SLIK5_HUMAN Decreases Expression [13]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Increases Expression [13]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Increases Expression [13]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Increases Expression [13]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [13]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Increases Expression [13]
Non-secretory ribonuclease (RNASE2) OT8Z4FNE RNAS2_HUMAN Increases Expression [13]
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) OT0OUDUT FCG2A_HUMAN Increases Expression [13]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [13]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [13]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [13]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Increases Expression [13]
Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C) OTNLMNYB FCG2C_HUMAN Increases Expression [13]
G protein-coupled receptor kinase 5 (GRK5) OTJK79EK GRK5_HUMAN Increases Expression [13]
RNA-binding protein 34 (RBM34) OTX3LUGI RBM34_HUMAN Decreases Expression [13]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Increases Expression [13]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [13]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Increases Expression [13]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) OTZ25I2W PGTB2_HUMAN Decreases Expression [13]
UV excision repair protein RAD23 homolog A (RAD23A) OTBPAWHX RD23A_HUMAN Decreases Expression [13]
Ras-related protein Rab-5B (RAB5B) OT06PN42 RAB5B_HUMAN Increases Expression [13]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [13]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Increases Expression [13]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [13]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [13]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [13]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [13]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) OTPFQ2QC ACAP1_HUMAN Increases Expression [13]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [13]
C3a anaphylatoxin chemotactic receptor (C3AR1) OT8J0TF8 C3AR_HUMAN Increases Expression [13]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Decreases Expression [13]
DALR anticodon-binding domain-containing protein 3 (DALRD3) OTU79VIP DALD3_HUMAN Decreases Expression [13]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Increases Expression [13]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Increases Expression [13]
DENN domain-containing protein 1A (DENND1A) OTONDAA0 DEN1A_HUMAN Increases Expression [13]
Serine protease FAM111A (FAM111A) OTVLARLG F111A_HUMAN Increases Expression [13]
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) OTG6F93V PPIP2_HUMAN Decreases Expression [13]
Partitioning defective 6 homolog alpha (PARD6A) OTWLV3X1 PAR6A_HUMAN Decreases Expression [13]
Mediator of RNA polymerase II transcription subunit 9 (MED9) OT59OKEJ MED9_HUMAN Decreases Expression [13]
Phospholipid-transporting ATPase VD (ATP10D) OT3JPE4H AT10D_HUMAN Increases Expression [13]
Bridging integrator 2 (BIN2) OT4S45WJ BIN2_HUMAN Increases Expression [13]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Increases Expression [13]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Decreases Expression [13]
Odontogenic ameloblast-associated protein (ODAM) OTT666SJ ODAM_HUMAN Decreases Expression [14]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3) OTF6I8RV PKHG3_HUMAN Decreases Expression [14]
Aldo-keto reductase family 1 member B15 (AKR1B15) OTUEXSWH AK1BF_HUMAN Decreases Expression [14]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Expression [14]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Decreases Expression [14]
Homeobox protein Meis1 (MEIS1) OTH9DKAD MEIS1_HUMAN Increases Expression [14]
Gamma-aminobutyric acid receptor subunit pi (GABRP) OTGKA8WS GBRP_HUMAN Increases Expression [14]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Decreases Expression [14]
Sarcolipin (SLN) OTERIU75 SARCO_HUMAN Decreases Expression [14]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Increases Expression [14]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Decreases Expression [14]
Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1) OT5DVN9P HS3S1_HUMAN Decreases Expression [14]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Decreases Expression [14]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [14]
Surfeit locus protein 4 (SURF4) OTCSXJ9C SURF4_HUMAN Decreases Expression [14]
Monocarboxylate transporter 4 (SLC16A3) OTDIXEXY MOT4_HUMAN Decreases Expression [14]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Decreases Expression [14]
Glycogenin-2 (GYG2) OTAJ7YEW GLYG2_HUMAN Decreases Expression [14]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Increases Expression [14]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Decreases Expression [14]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3) OT9ZS72C SRGP3_HUMAN Increases Expression [14]
Homeobox protein Hox-A2 (HOXA2) OT6G6ZIK HXA2_HUMAN Increases Expression [14]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Decreases Expression [14]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Decreases Expression [14]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [14]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [14]
ER lumen protein-retaining receptor 3 (KDELR3) OTW8C1V0 ERD23_HUMAN Decreases Expression [14]
Adhesion G protein-coupled receptor B3 (ADGRB3) OT1EWGRW AGRB3_HUMAN Increases Expression [14]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Decreases Expression [14]
Suppression of tumorigenicity 18 protein (ST18) OTPRIMTA ST18_HUMAN Increases Expression [14]
TBC1 domain family member 4 (TBC1D4) OTK66C40 TBCD4_HUMAN Decreases Expression [14]
Protein-tyrosine sulfotransferase 1 (TPST1) OTDPQKEA TPST1_HUMAN Decreases Expression [14]
Clathrin coat assembly protein AP180 (SNAP91) OTE3EXWZ AP180_HUMAN Increases Expression [14]
Kelch-like protein 41 (KLHL41) OTLABE56 KLH41_HUMAN Decreases Expression [14]
Perilipin-3 (PLIN3) OT9ZA7MR PLIN3_HUMAN Decreases Expression [14]
P antigen family member 4 (PAGE4) OT2VLWT0 PAGE4_HUMAN Decreases Expression [14]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [14]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Decreases Expression [14]
Leucine-rich repeat neuronal protein 2 (LRRN2) OTGP2DCY LRRN2_HUMAN Decreases Expression [14]
Cartilage-associated protein (CRTAP) OT53H5U6 CRTAP_HUMAN Decreases Expression [14]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [14]
Matrix metalloproteinase-23 (MMP23B) OT2OR6TS MMP23_HUMAN Decreases Expression [14]
Regulator of G-protein signaling 20 (RGS20) OT6CGYHW RGS20_HUMAN Increases Expression [14]
Lymphocyte antigen 6H (LY6H) OTTFGUD2 LY6H_HUMAN Decreases Expression [14]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Decreases Expression [14]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Increases Expression [14]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Decreases Expression [14]
SLIT and NTRK-like protein 3 (SLITRK3) OT018P93 SLIK3_HUMAN Decreases Expression [14]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [14]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Decreases Expression [14]
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) OT0I2B4J FBLN4_HUMAN Decreases Expression [14]
Heart- and neural crest derivatives-expressed protein 1 (HAND1) OTN4IPVV HAND1_HUMAN Decreases Expression [14]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [14]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Decreases Expression [14]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [14]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [14]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [14]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Decreases Expression [14]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [14]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [14]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Decreases Expression [14]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [14]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Decreases Expression [14]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Decreases Expression [14]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) OTTO6ZP4 AT1B1_HUMAN Decreases Expression [14]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Decreases Expression [14]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [14]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Expression [14]
Tyrosine 3-monooxygenase (TH) OT6ZORKP TY3H_HUMAN Decreases Expression [14]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Expression [14]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Decreases Expression [14]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Decreases Expression [14]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Decreases Expression [14]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Expression [14]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [14]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Decreases Expression [14]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Decreases Expression [14]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Expression [14]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Decreases Expression [14]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Decreases Expression [14]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Decreases Expression [14]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Decreases Expression [14]
Homeobox protein Hox-C6 (HOXC6) OTBCRAZV HXC6_HUMAN Decreases Expression [14]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Decreases Expression [14]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [14]
Thymosin beta-15A (TMSB15A) OTSBWCES TB15A_HUMAN Increases Expression [14]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Decreases Expression [14]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Decreases Expression [14]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Decreases Expression [14]
Hyaluronan and proteoglycan link protein 1 (HAPLN1) OTXWR9TJ HPLN1_HUMAN Decreases Expression [14]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [14]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [14]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Decreases Expression [14]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [14]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [14]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Decreases Expression [14]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [14]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [14]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Decreases Expression [14]
Annexin A8 (ANXA8) OTLSSQCY ANXA8_HUMAN Decreases Expression [14]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Decreases Expression [14]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [14]
N-chimaerin (CHN1) OTM196M3 CHIN_HUMAN Decreases Expression [14]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [14]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [14]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Decreases Expression [14]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [14]
Homeobox protein Hox-B8 (HOXB8) OTKHOD17 HXB8_HUMAN Decreases Expression [14]
Homeobox protein Hox-B4 (HOXB4) OTH1HRW5 HXB4_HUMAN Decreases Expression [14]
Homeobox protein Hox-B6 (HOXB6) OT3TFQ0U HXB6_HUMAN Decreases Expression [14]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Increases Expression [14]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [14]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Decreases Expression [14]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Decreases Expression [14]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Increases Expression [14]
Homeobox protein Hox-A5 (HOXA5) OTLWGPQD HXA5_HUMAN Increases Expression [14]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Decreases Expression [14]
Collagen alpha-1(IX) chain (COL9A1) OTWBR27Y CO9A1_HUMAN Increases Expression [14]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Decreases Expression [14]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [14]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [14]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [14]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Decreases Expression [14]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Decreases Expression [14]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Decreases Expression [14]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [14]
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) OT2NRISU PTPRZ_HUMAN Increases Expression [14]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [14]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [14]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [14]
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) OT3B1RGG CNTFR_HUMAN Increases Expression [14]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Decreases Expression [14]
Protein-lysine 6-oxidase (LOX) OT1C2HIU LYOX_HUMAN Decreases Expression [14]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Decreases Expression [14]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Decreases Expression [14]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Increases Expression [14]
Aquaporin-1 (AQP1) OTX5MYX9 AQP1_HUMAN Decreases Expression [14]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [14]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [14]
Translocator protein (TSPO) OTSU7ESK TSPO_HUMAN Decreases Expression [14]
Gastrin-releasing peptide receptor (GRPR) OTBQGYJT GRPR_HUMAN Decreases Expression [14]
Homeobox protein Hox-C8 (HOXC8) OTJUYU8J HXC8_HUMAN Decreases Expression [14]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [14]
Dimethylaniline monooxygenase 4 (FMO4) OT5UYZL7 FMO4_HUMAN Decreases Expression [14]
Gastrin/cholecystokinin type B receptor (CCKBR) OTQSNXOI GASR_HUMAN Decreases Expression [14]
Serpin B6 (SERPINB6) OT7G55IK SPB6_HUMAN Decreases Expression [14]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [14]
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Decreases Expression [14]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Decreases Expression [14]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Increases Expression [14]
Peripherin (PRPH) OT6VUH78 PERI_HUMAN Decreases Expression [14]
Transcription factor SOX-3 (SOX3) OT1CRCOB SOX3_HUMAN Increases Expression [14]
Glutamate receptor 2 (GRIA2) OT5N1WB7 GRIA2_HUMAN Increases Expression [14]
Troponin T, cardiac muscle (TNNT2) OT80NN7R TNNT2_HUMAN Decreases Expression [14]
Peptidyl-prolyl cis-trans isomerase C (PPIC) OTY5Q42N PPIC_HUMAN Decreases Expression [14]
Leptin receptor (LEPR) OT9H7G0C LEPR_HUMAN Decreases Expression [14]
Neuromedin-U (NMU) OTW9X7BQ NMU_HUMAN Increases Expression [14]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Increases Expression [14]
Casein kinase I isoform delta (CSNK1D) OTNF4S77 KC1D_HUMAN Decreases Expression [14]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Decreases Expression [14]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [14]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Decreases Expression [14]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Decreases Expression [14]
Serpin H1 (SERPINH1) OTKGI7BS SERPH_HUMAN Decreases Expression [14]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [14]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) OTOUZN9G LRBA_HUMAN Decreases Expression [14]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [14]
Neuronal membrane glycoprotein M6-a (GPM6A) OT8G13EG GPM6A_HUMAN Increases Expression [14]
Lumican (LUM) OTSRC874 LUM_HUMAN Decreases Expression [14]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) OT4O4NFS ROA3_HUMAN Decreases Expression [14]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Decreases Expression [14]
Cationic amino acid transporter 2 (SLC7A2) OTAMWBVM CTR2_HUMAN Decreases Expression [14]
Atrophin-1 (ATN1) OTNZFLKY ATN1_HUMAN Increases Expression [14]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A) OTU7J3F7 PDE1A_HUMAN Increases Expression [14]
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) OTC3RUN9 HMCS2_HUMAN Decreases Expression [14]
Phospholipid transfer protein (PLTP) OTVJJO5Z PLTP_HUMAN Decreases Expression [14]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Decreases Expression [14]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [14]
Claudin-15 (CLDN15) OT9K0KI7 CLD15_HUMAN Decreases Expression [14]
Junctional adhesion molecule B (JAM2) OTHVJJRJ JAM2_HUMAN Increases Expression [14]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Increases Expression [14]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Decreases Expression [14]
Heart- and neural crest derivatives-expressed protein 2 (HAND2) OTCXYW4Y HAND2_HUMAN Decreases Expression [14]
Neurocalcin-delta (NCALD) OTJZ8UEL NCALD_HUMAN Increases Expression [14]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Decreases Expression [14]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Decreases Expression [14]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Increases Expression [14]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Decreases Expression [14]
Oxidized low-density lipoprotein receptor 1 (OLR1) OTS44RIC OLR1_HUMAN Decreases Expression [14]
Iroquois-class homeodomain protein IRX-5 (IRX5) OT05J514 IRX5_HUMAN Increases Expression [14]
Reelin (RELN) OTLKMW1O RELN_HUMAN Decreases Expression [14]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Decreases Expression [14]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [14]
Matrix-remodeling-associated protein 7 (MXRA7) OTVQLYIY MXRA7_HUMAN Decreases Expression [14]
Disabled homolog 2 (DAB2) OTRMQTMZ DAB2_HUMAN Decreases Expression [14]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B) OT9NPJCR PDE1B_HUMAN Increases Expression [14]
Myosin regulatory light chain 2, atrial isoform (MYL7) OT7ZNDP4 MLRA_HUMAN Decreases Expression [14]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Decreases Expression [14]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Decreases Expression [14]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Decreases Expression [14]
Zinc finger protein basonuclin-1 (BNC1) OTGJ5WUF BNC1_HUMAN Decreases Expression [14]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Increases Expression [14]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) OTPTCBUN GCYA1_HUMAN Decreases Expression [14]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [14]
Desmocollin-2 (DSC2) OTODVH8K DSC2_HUMAN Decreases Expression [14]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Decreases Expression [14]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) OT3ZIANF PLOD1_HUMAN Decreases Expression [14]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [14]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Decreases Expression [14]
MBT domain-containing protein 1 (MBTD1) OT2P6943 MBTD1_HUMAN Increases Expression [14]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [14]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Increases Expression [14]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Decreases Expression [14]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [14]
Coiled-coil domain-containing protein 15 (CCDC15) OT1NZX84 CCD15_HUMAN Increases Expression [14]
Transmembrane protein 62 (TMEM62) OTJ4SPCM TMM62_HUMAN Increases Expression [14]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [14]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Decreases Expression [14]
Tyrosine-protein kinase Mer (MERTK) OTWBRAJ6 MERTK_HUMAN Decreases Expression [14]
Transmembrane emp24 domain-containing protein 1 (TMED1) OTWSH0J8 TMED1_HUMAN Decreases Expression [14]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Decreases Expression [14]
Transforming growth factor beta activator LRRC32 (LRRC32) OTG7EDZL LRC32_HUMAN Decreases Expression [14]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH) OTMCFF0K PIGH_HUMAN Decreases Expression [14]
Desmocollin-3 (DSC3) OTYG47F8 DSC3_HUMAN Decreases Expression [14]
Eukaryotic translation initiation factor 4H (EIF4H) OTGZI072 IF4H_HUMAN Decreases Expression [14]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Expression [14]
Phosphoglucomutase-like protein 5 (PGM5) OTEAS7OC PGM5_HUMAN Decreases Expression [14]
Nicotinate-nucleotide pyrophosphorylase (QPRT) OT6SKKLL NADC_HUMAN Decreases Expression [14]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [14]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Decreases Expression [14]
Probable G-protein coupled receptor 19 (GPR19) OTR7MUS5 GPR19_HUMAN Increases Expression [14]
Alpha-internexin (INA) OT1D33T4 AINX_HUMAN Increases Expression [14]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Decreases Expression [14]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Decreases Expression [14]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Increases Expression [14]
Discoidin domain-containing receptor 2 (DDR2) OT9IHOGZ DDR2_HUMAN Decreases Expression [14]
Rho GTPase-activating protein 44 (ARHGAP44) OTHJUCO1 RHG44_HUMAN Decreases Expression [14]
Sodium-coupled monocarboxylate transporter 2 (SLC5A12) OTKY9NAL SC5AC_HUMAN Decreases Expression [14]
Keratin, type I cytoskeletal 24 (KRT24) OTR7MT1E K1C24_HUMAN Decreases Expression [14]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8) OTKJ0X6Q S4A8_HUMAN Decreases Expression [14]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Decreases Expression [14]
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (MINDY4) OTBZ2SZB MINY4_HUMAN Decreases Expression [14]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1) OT6Z1L2E PLCH1_HUMAN Increases Expression [14]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Decreases Expression [14]
PDZ and LIM domain protein 3 (PDLIM3) OTVXQC81 PDLI3_HUMAN Increases Expression [14]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Decreases Expression [14]
Cordon-bleu protein-like 1 (COBLL1) OTQFN1TC COBL1_HUMAN Decreases Expression [14]
Spindlin-4 (SPIN4) OT09ZWHM SPIN4_HUMAN Decreases Expression [14]
Trans-2,3-enoyl-CoA reductase-like (TECRL) OTXLSNCP TECRL_HUMAN Decreases Expression [14]
Placenta-specific protein 9 (PLAC9) OTZHIJ44 PLAC9_HUMAN Decreases Expression [14]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Decreases Expression [14]
CUGBP Elav-like family member 3 (CELF3) OTTP45WK CELF3_HUMAN Increases Expression [14]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) OT5WC0Q8 KANK4_HUMAN Decreases Expression [14]
Transcription factor HES-5 (HES5) OTW7JEHV HES5_HUMAN Increases Expression [14]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Expression [14]
Terminal nucleotidyltransferase 5C (TENT5C) OTOWVQ4O TET5C_HUMAN Decreases Expression [14]
FYN-binding protein 2 (FYB2) OTA3NG8M FYB2_HUMAN Decreases Expression [14]
F-actin-uncapping protein LRRC16A (CARMIL1) OT1A5IX5 CARL1_HUMAN Decreases Expression [14]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Decreases Expression [14]
Carboxypeptidase Z (CPZ) OT5HUR28 CBPZ_HUMAN Decreases Expression [14]
NADH-cytochrome b5 reductase 2 (CYB5R2) OTTLM7XN NB5R2_HUMAN Decreases Expression [14]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Increases Expression [14]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Decreases Expression [14]
Cdc42 effector protein 5 (CDC42EP5) OTQQDUCD BORG3_HUMAN Decreases Expression [14]
Cytochrome b5 domain-containing protein 1 (CYB5D1) OTSZWTPT CB5D1_HUMAN Decreases Expression [14]
Transmembrane protein 88 (TMEM88) OTA96YEL TMM88_HUMAN Decreases Expression [14]
Protein cornichon homolog 2 (CNIH2) OTT2ECCW CNIH2_HUMAN Increases Expression [14]
Prostate androgen-regulated mucin-like protein 1 (PARM1) OTDNK7EX PARM1_HUMAN Decreases Expression [14]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Decreases Expression [14]
R-spondin-2 (RSPO2) OT3HHXU0 RSPO2_HUMAN Decreases Expression [14]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Decreases Expression [14]
Staphylococcal nuclease domain-containing protein 1 (SND1) OTT734JN SND1_HUMAN Decreases Expression [14]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Increases Expression [14]
Centriolin (CNTRL) OTQI3VBA CNTRL_HUMAN Increases Expression [14]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) OTKCR5XL CK2N1_HUMAN Increases Expression [14]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Increases Expression [14]
Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10) OTZ6FDOL GLT10_HUMAN Decreases Expression [14]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Decreases Expression [14]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [14]
Transmembrane protein 200A (TMEM200A) OTVJZIOR T200A_HUMAN Decreases Expression [14]
Podoplanin (PDPN) OTBUV19I PDPN_HUMAN Decreases Expression [14]
Rhophilin-2 (RHPN2) OTTYWMF6 RHPN2_HUMAN Decreases Expression [14]
Epidermal growth factor-like protein 6 (EGFL6) OT331X59 EGFL6_HUMAN Decreases Expression [14]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Decreases Expression [14]
Neuron navigator 2 (NAV2) OTGAOL01 NAV2_HUMAN Decreases Expression [14]
Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON) OTBHAW5K SBSPO_HUMAN Decreases Expression [14]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Decreases Expression [14]
Sperm-associated antigen 16 protein (SPAG16) OTIFUPYD SPG16_HUMAN Increases Expression [14]
Cytochrome P450 4X1 (CYP4X1) OTMTEUNE CP4X1_HUMAN Decreases Expression [14]
Inactive serine protease 35 (PRSS35) OT09H6WH PRS35_HUMAN Decreases Expression [14]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [14]
Reprimo-like protein (RPRML) OTPOESFN RPRML_HUMAN Increases Expression [14]
Actin filament-associated protein 1-like 2 (AFAP1L2) OTJBI0VN AF1L2_HUMAN Decreases Expression [14]
Protocadherin-20 (PCDH20) OTFSNRXK PCD20_HUMAN Decreases Expression [14]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Increases Expression [14]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3) OTLAQ14Q SIA7C_HUMAN Decreases Expression [14]
Trinucleotide repeat-containing gene 6A protein (TNRC6A) OT493IOM TNR6A_HUMAN Increases Expression [14]
Coiled-coil domain-containing protein 112 (CCDC112) OT3OEYG6 CC112_HUMAN Increases Expression [14]
Class E basic helix-loop-helix protein 22 (BHLHE22) OTZUQY5L BHE22_HUMAN Increases Expression [14]
Secretory carrier-associated membrane protein 5 (SCAMP5) OT9MXA2J SCAM5_HUMAN Increases Expression [14]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Decreases Expression [14]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Decreases Expression [14]
Protein MGARP (MGARP) OTL90XO8 HUMMR_HUMAN Decreases Expression [14]
Mucolipin-3 (MCOLN3) OTCRPRVS MCLN3_HUMAN Decreases Expression [14]
Breast carcinoma-amplified sequence 4 (BCAS4) OT596N5E BCAS4_HUMAN Decreases Expression [14]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) OT2IVOK4 SH3R2_HUMAN Decreases Expression [14]
Docking protein 4 (DOK4) OTUEWLG8 DOK4_HUMAN Decreases Expression [14]
Probable phospholipid-transporting ATPase IM (ATP8B4) OT48TSYO AT8B4_HUMAN Decreases Expression [14]
Cell migration-inducing and hyaluronan-binding protein (CEMIP) OTK80FYN CEMIP_HUMAN Decreases Expression [14]
Leucine-rich repeat neuronal protein 4 (LRRN4) OTC2T1MP LRRN4_HUMAN Decreases Expression [14]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Decreases Expression [14]
Atlastin-1 (ATL1) OTR2788Y ATLA1_HUMAN Increases Expression [14]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Decreases Expression [14]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) OTQDYH8E ASM3A_HUMAN Decreases Expression [14]
SEC14-like protein 1 (SEC14L1) OTA75FET S14L1_HUMAN Decreases Expression [14]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Expression [14]
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) OTYZP3MP ANS1A_HUMAN Decreases Expression [14]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Decreases Expression [14]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Decreases Expression [14]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [14]
Proprotein convertase subtilisin/kexin type 5 (PCSK5) OTP0RJ4Y PCSK5_HUMAN Decreases Expression [14]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Decreases Expression [14]
Exostosin-2 (EXT2) OT8IR5QN EXT2_HUMAN Decreases Expression [14]
Ecto-ADP-ribosyltransferase 4 (ART4) OTTV2J54 NAR4_HUMAN Decreases Expression [14]
Caveolae-associated protein 3 (CAVIN3) OTOLBK79 CAVN3_HUMAN Decreases Expression [14]
Myeloid-derived growth factor (MYDGF) OT9HRPL6 MYDGF_HUMAN Decreases Expression [14]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6) OT3C3VWX SIA7F_HUMAN Decreases Expression [14]
Coiled-coil domain-containing protein 102A (CCDC102A) OTT7XHIP C102A_HUMAN Decreases Expression [14]
Ras-related and estrogen-regulated growth inhibitor (RERG) OTF6MMLV RERG_HUMAN Decreases Expression [14]
Ras-related protein Rab-37 (RAB37) OTRL8IUO RAB37_HUMAN Decreases Expression [14]
Store-operated calcium entry-associated regulatory factor (SARAF) OTH5JIFE SARAF_HUMAN Decreases Expression [14]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [14]
Multivesicular body subunit 12A (MVB12A) OT3737K0 MB12A_HUMAN Decreases Expression [14]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) OTMLBCLC PELI1_HUMAN Increases Expression [14]
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL) OT9EIUGH PHIPL_HUMAN Increases Expression [14]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Decreases Expression [14]
Vacuolar-sorting protein SNF8 (SNF8) OTRQA2AI SNF8_HUMAN Decreases Expression [14]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Increases Expression [14]
PC-esterase domain-containing protein 1B (PCED1B) OT19CDAB PED1B_HUMAN Decreases Expression [14]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Decreases Expression [14]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) OTY5HZN5 LRIG1_HUMAN Increases Expression [14]
Lysyl oxidase homolog 4 (LOXL4) OT6XY2JL LOXL4_HUMAN Decreases Expression [14]
Multiple epidermal growth factor-like domains protein 10 (MEGF10) OTILSPJ6 MEG10_HUMAN Increases Expression [14]
N-terminal kinase-like protein (SCYL1) OTQ0IN7P SCYL1_HUMAN Decreases Expression [14]
Ecto-ADP-ribosyltransferase 5 (ART5) OTEZUT8V NAR5_HUMAN Decreases Expression [14]
Protein phosphatase 1M (PPM1M) OTCPLZQ7 PPM1M_HUMAN Decreases Expression [14]
Roundabout homolog 3 (ROBO3) OTPVG40S ROBO3_HUMAN Increases Expression [14]
Prickle-like protein 1 (PRICKLE1) OT9HHEM9 PRIC1_HUMAN Decreases Expression [14]
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5) OTK7QZ3B LRFN5_HUMAN Decreases Expression [14]
Guanylate-binding protein 4 (GBP4) OTSPNGKX GBP4_HUMAN Decreases Expression [14]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Increases Expression [14]
Myeloid-associated differentiation marker (MYADM) OTZTZI7P MYADM_HUMAN Decreases Expression [14]
Protein Niban 2 (NIBAN2) OTVDQSPI NIBA2_HUMAN Decreases Expression [14]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Increases Expression [14]
Protein kinase C-binding protein NELL2 (NELL2) OTS4MJZ7 NELL2_HUMAN Increases Expression [14]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Decreases Expression [14]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Decreases Expression [14]
Plakophilin-2 (PKP2) OTJOVF68 PKP2_HUMAN Decreases Expression [14]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Decreases Expression [14]
Ribosome quality control complex subunit TCF25 (TCF25) OTTFHHU9 TCF25_HUMAN Decreases Expression [14]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [14]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Expression [14]
Transcription elongation factor A protein-like 7 (TCEAL7) OTNPDZCN TCAL7_HUMAN Increases Expression [14]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Decreases Expression [14]
Ribonuclease P protein subunit p25 (RPP25) OTEN6QN7 RPP25_HUMAN Decreases Expression [14]
EF-hand domain-containing protein D1 (EFHD1) OTL5INE4 EFHD1_HUMAN Decreases Expression [14]
Arginine/serine-rich protein 1 (RSRP1) OTOAZLCL RSRP1_HUMAN Decreases Expression [14]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Decreases Expression [14]
Max dimerization protein 3 (MXD3) OT4U88UP MAD3_HUMAN Increases Expression [14]
Transcription factor GATA-5 (GATA5) OTO81B63 GATA5_HUMAN Decreases Expression [14]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Decreases Expression [14]
Uncharacterized protein KIAA1671 (KIAA1671) OTYGNSCG K1671_HUMAN Decreases Expression [14]
Tripartite motif-containing protein 6 (TRIM6) OTBSMX0B TRIM6_HUMAN Decreases Expression [14]
Tripartite motif-containing protein 5 (TRIM5) OTMZH7EJ TRIM5_HUMAN Decreases Expression [14]
RNA exonuclease 4 (REXO4) OT2NNFKZ REXO4_HUMAN Decreases Expression [14]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Decreases Expression [14]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Decreases Expression [14]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Decreases Expression [14]
Small conductance calcium-activated potassium channel protein 2 (KCNN2) OTQVTMK5 KCNN2_HUMAN Decreases Expression [14]
Thiamin pyrophosphokinase 1 (TPK1) OTCHPUD0 TPK1_HUMAN Decreases Expression [14]
SPARC-related modular calcium-binding protein 2 (SMOC2) OTK1EQ49 SMOC2_HUMAN Decreases Expression [14]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [14]
RWD domain-containing protein 1 (RWDD1) OTVEZWQG RWDD1_HUMAN Increases Expression [14]
Calcium-binding protein 39-like (CAB39L) OTQEBL0W CB39L_HUMAN Decreases Expression [14]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Decreases Expression [14]
Anoctamin-8 (ANO8) OT07SRRX ANO8_HUMAN Increases Expression [14]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Expression [14]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Decreases Expression [14]
Zinc transporter ZIP2 (SLC39A2) OTE0GI4W S39A2_HUMAN Decreases Expression [14]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Decreases Expression [14]
Nuclear receptor-interacting protein 3 (NRIP3) OTU15GMK NRIP3_HUMAN Decreases Expression [14]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Decreases Expression [14]
PR domain zinc finger protein 8 (PRDM8) OTRA3265 PRDM8_HUMAN Increases Expression [14]
Integral membrane protein 2C (ITM2C) OTHVMXE3 ITM2C_HUMAN Decreases Expression [14]
Rho guanine nucleotide exchange factor 3 (ARHGEF3) OTHGNC0A ARHG3_HUMAN Decreases Expression [14]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Decreases Expression [14]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Increases Expression [14]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Decreases Expression [14]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Decreases Expression [14]
Host cell factor C1 regulator 1 (HCFC1R1) OTGDPS5C HPIP_HUMAN Decreases Expression [14]
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) OT65C86U IMPA3_HUMAN Decreases Expression [14]
PH and SEC7 domain-containing protein 3 (PSD3) OTTN9B9O PSD3_HUMAN Increases Expression [14]
G-protein coupled receptor 83 (GPR83) OT7A2FE8 GPR83_HUMAN Decreases Expression [14]
Podocalyxin-like protein 2 (PODXL2) OTB3PUR8 PDXL2_HUMAN Increases Expression [14]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Decreases Expression [14]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Decreases Expression [14]
Low-density lipoprotein receptor-related protein 1B (LRP1B) OT4YZG2N LRP1B_HUMAN Decreases Expression [14]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Decreases Expression [14]
Protein PALS2 (PALS2) OTV12NKE PALS2_HUMAN Decreases Expression [14]
Spermatogenesis-associated protein 7 (SPATA7) OT78G2IH SPAT7_HUMAN Increases Expression [14]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Expression [14]
C-type lectin domain family 1 member B (CLEC1B) OTO38TRG CLC1B_HUMAN Decreases Expression [14]
Dynein axonemal heavy chain 2 (DNAH2) OT7J5LDI DYH2_HUMAN Decreases Expression [14]
Semaphorin-5B (SEMA5B) OTUVSKK0 SEM5B_HUMAN Increases Expression [14]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Decreases Expression [14]
Protein dispatched homolog 3 (DISP3) OTEW6RYT DISP3_HUMAN Increases Expression [14]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Decreases Expression [14]
Vesicular glutamate transporter 2 (SLC17A6) OTP1MJGP VGLU2_HUMAN Increases Expression [14]
Beta-1,4-galactosyltransferase 7 (B4GALT7) OTG5WHRW B4GT7_HUMAN Decreases Expression [14]
Tachykinin-3 (TAC3) OTOJGM38 TKNK_HUMAN Decreases Expression [14]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [14]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) OTZ71SK9 BI2L1_HUMAN Decreases Expression [14]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Decreases Expression [14]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Decreases Expression [14]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Decreases Expression [14]
Microtubule-associated tumor suppressor 1 (MTUS1) OTBPALMU MTUS1_HUMAN Increases Expression [14]
Y+L amino acid transporter 1 (SLC7A7) OTYNABBR YLAT1_HUMAN Decreases Expression [14]
Lysosomal thioesterase PPT2 (PPT2) OTD5VJ9A PPT2_HUMAN Decreases Expression [14]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [14]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [14]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Decreases Expression [14]
Nuclease EXOG, mitochondrial (EXOG) OTZAI8L7 EXOG_HUMAN Decreases Expression [14]
Netrin-G1 (NTNG1) OTF48IID NTNG1_HUMAN Increases Expression [14]
Protein SSUH2 homolog (SSUH2) OTWUBDV0 SSUH2_HUMAN Increases Expression [14]
Transmembrane protein 98 (TMEM98) OTKDUEED TMM98_HUMAN Decreases Expression [14]
Plasmolipin (PLLP) OTFGCB9U PLLP_HUMAN Decreases Expression [14]
C2 domain-containing protein 2 (C2CD2) OTL1K0OB C2CD2_HUMAN Decreases Expression [14]
Talin-2 (TLN2) OT10QQBC TLN2_HUMAN Decreases Expression [14]
Protein mab-21-like 2 (MAB21L2) OTZM5VMX MB212_HUMAN Decreases Expression [14]
Transient receptor potential cation channel subfamily V member 2 (TRPV2) OT0A9AVD TRPV2_HUMAN Decreases Expression [14]
Transcription factor SOX-21 (SOX21) OTNT50CC SOX21_HUMAN Increases Expression [14]
LHFPL tetraspan subfamily member 6 protein (LHFPL6) OTY6LHJY LHPL6_HUMAN Increases Expression [14]
Stonin-1 (STON1) OT2HPUAI STON1_HUMAN Decreases Expression [14]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Increases Expression [16]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Decreases Expression [30]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [31]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [15]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [32]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Expression [33]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Affects Localization [34]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [35]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [36]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [30]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Decreases Activity [37]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [36]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [38]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Secretion [39]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Degradation [40]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [38]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [37]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [16]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [16]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [15]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [16]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [41]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [15]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Decreases Expression [16]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [42]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2) OTPAHDGO PLCB2_HUMAN Affects Localization [43]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Activity [44]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [45]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [46]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Increases Expression [16]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [15]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [15]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [15]
Jouberin (AHI1) OT8K2YWY AHI1_HUMAN Increases Expression [47]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Affects Localization [48]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [16]
Solute carrier family 12 member 6 (SLC12A6) OT9CS413 S12A6_HUMAN Decreases Expression [16]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) OT27CCUF SIAT9_HUMAN Decreases Expression [16]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Decreases Expression [16]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Increases ADR [49]
Kynurenine 3-monooxygenase (KMO) OT3MRMM9 KMO_HUMAN Increases Response To Substance [50]
Stathmin-4 (STMN4) OT7ZUKW6 STMN4_HUMAN Increases Response To Substance [50]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Response To Substance [51]
Protein lyl-1 (LYL1) OTCNOV1M LYL1_HUMAN Decreases Response To Substance [52]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Decreases Response To Substance [53]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Increases Response To Substance [50]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases ADR [49]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Affects Response To Substance [54]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [55]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Response To Substance [56]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Decreases Response To Substance [57]
Calcitonin receptor (CALCR) OTOVDJ7S CALCR_HUMAN Increases Response To Substance [50]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Response To Substance [58]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [18]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Affects Response To Substance [53]
Deoxycytidine kinase (DCK) OTW8HLZC DCK_HUMAN Decreases Response To Substance [29]
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⏷ Show the Full List of 549 DOT(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 ClinicalTrials.gov (NCT04472598) Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis (TRANSFORM-1). U.S. National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8319).
4 Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
6 Cytarabine FDA Label
7 Clinical pipeline report, company report or official report of Roche (2009).
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9.
10 Effect of rifampin on the pharmacokinetics, safety and tolerability of navitoclax (ABT-263), a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer. J Clin Pharm Ther. 2014 Dec;39(6):680-4.
11 Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin. Toxicol In Vitro. 2018 Feb;46:229-236. doi: 10.1016/j.tiv.2017.09.023. Epub 2017 Sep 23.
12 BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11.
13 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
14 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
15 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
16 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
17 Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000 May;6(5):1796-803.
18 Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15;105(12):4752-8. doi: 10.1182/blood-2004-11-4544. Epub 2005 Feb 15.
19 Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2014 Feb;1843(2):387-97. doi: 10.1016/j.bbamcr.2013.10.015. Epub 2013 Oct 31.
20 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
21 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
22 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
23 OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
24 FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
25 Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20.
26 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
27 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
28 [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. Ontogenez. 2001 Jul-Aug;32(4):295-301.
29 Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008 Apr 1;68(7):2349-57. doi: 10.1158/0008-5472.CAN-07-5528.
30 Arabinosylcytosine downregulates thymidine kinase and induces cross-resistance to zidovudine in T-lymphoid cells. Biochem Biophys Res Commun. 2003 Aug 1;307(3):564-8. doi: 10.1016/s0006-291x(03)01232-4.
31 [Combined effect of TNF-related apoptosis induced ligand and Ara-C in inducing apoptosis of HL-60 cells and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):510-5.
32 JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):440-50. doi: 10.1016/j.bbrc.2005.12.197. Epub 2006 Jan 11.
33 The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
34 Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. Thromb Res. 2002 Apr 1;106(1):63-70. doi: 10.1016/s0049-3848(02)00075-0.
35 Prolactinemia in adolescent males surviving malignancies in childhood: impaired dating activity. J Adolesc Health. 1993 Nov;14(7):543-7. doi: 10.1016/1054-139x(93)90138-f.
36 Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children. Med Pediatr Oncol. 2001 Nov;37(5):459-64. doi: 10.1002/mpo.1230.
37 Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines. J Pharmacol Exp Ther. 2009 Oct;331(1):77-86. doi: 10.1124/jpet.109.155671. Epub 2009 Jul 23.
38 Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1992 Dec 1;80(11):2883-90.
39 [Influence of HMGB1/MAPK/m-TOR signaling pathway on cell autophagy and chemotherapy resistance in K562 cells]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct 28;41(10):1016-1023. doi: 10.11817/j.issn.1672-7347.2016.10.002.
40 Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res. 1996 Oct 15;56(20):4743-8.
41 Ara-C induces apoptosis in monkey fibroblast cells. Toxicol In Vitro. 2003 Jun;17(3):367-73. doi: 10.1016/s0887-2333(03)00024-9.
42 Cytosine arabinoside induced acute interstitial nephritis in a patient treated for refractory anemia with excess of blasts in transformation. Nephron. 2000 Nov;86(3):356-7. doi: 10.1159/000045798.
43 Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. J Biol Chem. 1997 Sep 19;272(38):23481-4. doi: 10.1074/jbc.272.38.23481.
44 Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. Oncogene. 2003 Jul 10;22(28):4356-69. doi: 10.1038/sj.onc.1206486.
45 Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment. Cell Death Differ. 1998 Jul;5(7):584-91. doi: 10.1038/sj.cdd.4400382.
46 The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells. Haematologica. 2006 Jul;91(7):912-9.
47 [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
48 Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons. J Neurooncol. 2008 Aug;89(1):1-7. doi: 10.1007/s11060-008-9585-6. Epub 2008 Apr 15.
49 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
50 Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
51 In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. Leukemia. 2004 Mar;18(3):521-9. doi: 10.1038/sj.leu.2403253.
52 Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia. 2005 Nov;19(11):1941-7. doi: 10.1038/sj.leu.2403836.
53 DNA methylation and sensitivity to antimetabolites in cancer cell lines. Oncol Rep. 2008 Feb;19(2):407-12.
54 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
55 Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent. Toxicol Sci. 2014 Jul;140(1):94-102. doi: 10.1093/toxsci/kfu058. Epub 2014 Mar 27.
56 Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
57 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKC. J Med Chem. 2011 Oct 13;54(19):6714-23. doi: 10.1021/jm2005892. Epub 2011 Sep 14.
58 Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.