Details of the Drug Combination

General Information of Drug Combination (ID: DCTXME4)

• Drug Combination Name: Vismodegib + Plicamycin
• Indication: Adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Vismodegib (DM5IXKQ): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: DU-145
  Zero Interaction Potency (ZIP) Score: 16.64
  Bliss Independence Score: 21.42
  Loewe Additivity Score: 18.8
  LHighest Single Agent (HSA) Score: 18.72

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Vismodegib

Disease Entry	ICD 11	Status	REF
Basal cell carcinoma	2C32	Approved	[2]
Primitive neuroectodermal tumour medulloblastoma	2A00.11	Phase 2	[3]

Vismodegib Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Smoothened homolog (SMO)	TT8J1S3	SMO_HUMAN	Modulator	[7]

Vismodegib Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[8]

Vismodegib Interacts with 13 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[9]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[9]
Zinc finger protein GLI1 (GLI1)	OT1BTAJO	GLI1_HUMAN	Decreases Expression	[9]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Decreases Expression	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[9]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Expression	[9]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[9]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[9]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Decreases Expression	[9]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[9]
Protein patched homolog 2 (PTCH2)	OTOQ0K9V	PTC2_HUMAN	Decreases Expression	[9]
Suppressor of fused homolog (SUFU)	OT0IRYG1	SUFU_HUMAN	Decreases Response To Substance	[10]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Response To Substance	[10]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[4]
Testicular cancer	2C80	Approved	[4]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[5]
Lung cancer	2C25.0	Investigative	[6]
Ovarian cancer	2C73	Investigative	[6]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[12]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[13]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[14]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[14]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[14]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[15]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[15]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[16]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[11]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[17]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[18]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[19]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[11]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[20]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[17]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[21]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[22]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Breast adenocarcinoma	DCLEA4E	MDA-MB-468	Investigative	[23]
Carcinoma	DCBKWNH	RXF 393	Investigative	[23]
Carcinoma	DCGGB2G	MCF7	Investigative	[23]
Colon adenocarcinoma	DCB1RJN	COLO 205	Investigative	[23]
Colon carcinoma	DCIHIS4	KM12	Investigative	[23]
Invasive ductal carcinoma	DC7MKIN	HS 578T	Investigative	[23]
Invasive ductal carcinoma	DC1JVD5	BT-549	Investigative	[23]
Invasive ductal carcinoma	DCMEQRO	T-47D	Investigative	[23]
Adenocarcinoma	DCG2MMK	OVCAR3	Investigative	[1]
Adenocarcinoma	DCM5SO5	NCIH23	Investigative	[1]
Adenocarcinoma	DCVBNR2	A549	Investigative	[1]
Adenocarcinoma	DCX2KEU	SW-620	Investigative	[1]
Adenocarcinoma	DCKN4FX	HT29	Investigative	[1]
Adenocarcinoma	DCCUBBT	HCT116	Investigative	[1]
Adenocarcinoma	DCQV22I	HCC-2998	Investigative	[1]
Adenocarcinoma	DC1BDZS	HCT-15	Investigative	[1]
Adult acute myeloid leukemia	DCPXMVW	HL-60(TB)	Investigative	[1]
Adult T acute lymphoblastic leukemia	DCC6DIU	MOLT-4	Investigative	[1]
Amelanotic melanoma	DCCZ9ZH	M14	Investigative	[1]
Amelanotic melanoma	DCGDOKI	MDA-MB-435	Investigative	[1]
Anaplastic large cell lymphoma	DC7NMBP	SR	Investigative	[1]
Astrocytoma	DCRJWU1	U251	Investigative	[1]
Astrocytoma	DCW91Z3	SNB-19	Investigative	[1]
Childhood T acute lymphoblastic leukemia	DCS9T4Y	CCRF-CEM	Investigative	[1]
Chronic myelogenous leukemia	DCZQRX8	K-562	Investigative	[1]
Clear cell renal cell carcinoma	DCKN4HV	TK-10	Investigative	[1]
Clear cell renal cell carcinoma	DCCHRLV	786-0	Investigative	[1]
Clear cell renal cell carcinoma	DCHJ0BT	A498	Investigative	[1]
Clear cell renal cell carcinoma	DC73YCW	CAKI-1	Investigative	[1]
Cutaneous melanoma	DCBCLMM	SK-MEL-5	Investigative	[1]
Cutaneous melanoma	DC9TDZB	SK-MEL-28	Investigative	[1]
Glioblastoma	DCJWXRD	SNB-75	Investigative	[1]
Glioma	DCA2JMR	SF-539	Investigative	[1]
Glioma	DCO0DKH	SF-268	Investigative	[1]
Glioma	DCUO9ZK	SF-295	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCQMY29	OVCAR-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC4B6II	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCG83A6	OVCAR-4	Investigative	[1]
Large cell lung carcinoma	DCGOKUU	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DC4KTV5	MDA-MB-231	Investigative	[1]
Lung adenocarcinoma	DCY9RJ5	EKVX	Investigative	[1]
Lung adenocarcinoma	DCB4OVA	HOP-62	Investigative	[1]
Lung adenocarcinoma	DCZQ6NC	NCI-H522	Investigative	[1]
Malignant melanoma	DCSNYNM	UACC62	Investigative	[1]
Malignant melanoma	DC5RVLC	LOX IMVI	Investigative	[1]
Melanoma	DCQZCEW	SK-MEL-2	Investigative	[1]
Melanoma	DCFCDEV	UACC-257	Investigative	[1]
Melanoma	DC7AS3H	MALME-3M	Investigative	[1]
Minimally invasive lung adenocarcinoma	DC63WZ7	NCI-H322M	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DC3NCKM	IGROV1	Investigative	[1]
Non-small cell lung carcinoma	DCWU77T	HOP-92	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCZ20C5	SK-OV-3	Investigative	[1]
Papillary renal cell carcinoma	DCKX3NP	ACHN	Investigative	[1]
Plasma cell myeloma	DC0B4ID	RPMI-8226	Investigative	[1]
Pleural epithelioid mesothelioma	DCVJQT0	NCI-H226	Investigative	[1]
Prostate carcinoma	DCV43TU	PC-3	Investigative	[1]
Renal cell carcinoma	DCLRXZY	UO-31	Investigative	[1]
Renal cell carcinoma	DCL41I9	SN12C	Investigative	[1]

References

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