Details of the Drug Combinations

General Information of This Drug (ID: DMA9SEY)

Drug Name
GDC-0084   DMA9SEY
Synonyms GDC-0084/RG7666
Indication
Disease Entry ICD 11 Status REF
Glioblastoma of brain 2A00.00 Phase 2 [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

77 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + GDC-0084 DCG0S39 ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
Bardoxolone methyl + GDC-0084 DC33TFM Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [3]
Bleomycin + GDC-0084 DC26ZNV Bleomycin Hodgkin lymphoma (Cell Line: HDLM-2) [2]
Bleomycin + GDC-0084 DCGTE8M Bleomycin Hodgkin lymphoma (Cell Line: L-428) [2]
Decitabine + GDC-0084 DCKB0FQ Decitabine Ewing sarcoma (Cell Line: TC-71) [3]
Eltanexor oral + GDC-0084 DCJ0YIF Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [3]
Etoposide + GDC-0084 DC4S7JQ Etoposide Ewing sarcoma (Cell Line: TC-71) [3]
Everolimus + GDC-0084 DCIRVQU Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
Fomepizole + GDC-0084 DC51Y2A Fomepizole Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Lumefantrine DCS1X2H Lumefantrine DD2 (Cell Line: DD2) [3]
GDC-0084 + AT13387 DC115GZ AT13387 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + PF-3758309 DC147GE PF-3758309 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Carfilzomib DC54JBM Carfilzomib Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Panobinostat DCWIGQ5 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
GDC-0084 + Eltanexor oral DCGCS6W Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Formononetin DCG8AGK Formononetin Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Everolimus DCYZ3LG Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + BN-2629 DCOEY77 BN-2629 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + PMID25656651-Compound-5 DCFLGGM PMID25656651-Compound-5 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Exherin DC67WKW Exherin Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Emetine DCP8565 Emetine DD2 (Cell Line: DD2) [3]
GDC-0084 + THAPSIGARGIN DCU0VM6 THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Withaferin A DCMJQUT Withaferin A Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + OSI-906 DC62X1V OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Bardoxolone methyl DCYNRXX Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Ispinesib DCHOSM1 Ispinesib Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + (-)-englerin A DC0VTEM (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Naltrexone DC7SNNM Naltrexone DD2 (Cell Line: DD2) [3]
GDC-0084 + Quinine DCUBHWP Quinine DD2 (Cell Line: DD2) [3]
GDC-0084 + Romidepsin DC4UT2Y Romidepsin Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + NVP-AUY922 DC44D7V NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Mitotane DCWGMAI Mitotane Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Mefloquine DCOTCG3 Mefloquine DD2 (Cell Line: DD2) [3]
GDC-0084 + ZSTK474 DC3B96O ZSTK474 DD2 (Cell Line: DD2) [3]
GDC-0084 + Doxorubicin DCXIUC5 Doxorubicin Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Cytarabine DCA6JV0 Cytarabine Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + CP-868596 DCX00PF CP-868596 Ewing sarcoma (Cell Line: TC-71) [3]
GDC-0084 + Ruxolitinib DC9NGQ2 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Ruxolitinib DCT2GMU Ruxolitinib Hodgkin lymphoma (Cell Line: HDLM-2) [2]
GDC-0084 + Ombrabulin DCODPCP Ombrabulin Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Trametinib DCROZ8H Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
GDC-0084 + Trametinib DCW5YT2 Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
GDC-0084 + Trametinib DC7CN1A Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
GDC-0084 + Panobinostat DCFIW64 Panobinostat Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Ym155 DCMIBJB Ym155 Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + SCH 727965 DC4ROEY SCH 727965 Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Emetine DCWZILX Emetine Hepatoblastoma (Cell Line: HB3) [2]
GDC-0084 + Cotellic DC60IMQ Cotellic Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
GDC-0084 + Cotellic DCSD7MA Cotellic Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
GDC-0084 + Cotellic DCP8Q4J Cotellic Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
GDC-0084 + SNX-5422 DCQN986 SNX-5422 Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Azathioprine DCZK8AV Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + ABT-263 DCL0NWT ABT-263 Hodgkin lymphoma (Cell Line: L-1236) [2]
GDC-0084 + Artemisinin DCGH4F9 Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
GDC-0084 + Naltrexone DCV2D27 Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
GDC-0084 + Quinine DCVFRKE Quinine Hepatoblastoma (Cell Line: HB3) [2]
GDC-0084 + BGT226 DCI67ZQ BGT226 Hodgkin lymphoma (Cell Line: L-1236) [2]
IMD-0354 + GDC-0084 DCGY5R1 IMD-0354 Hodgkin lymphoma (Cell Line: L-1236) [2]
JQ1 + GDC-0084 DCYS331 JQ1 Ewing sarcoma (Cell Line: TC-71) [3]
LY2523355 + GDC-0084 DCSYZVT LY2523355 Ewing sarcoma (Cell Line: TC-71) [3]
LY2874455 + GDC-0084 DCOCQV8 LY2874455 Ewing sarcoma (Cell Line: TC-71) [3]
Mitomycin + GDC-0084 DC3504I Mitomycin Ewing sarcoma (Cell Line: TC-71) [3]
MK-1775 + GDC-0084 DCSYH40 MK-1775 Ewing sarcoma (Cell Line: TC-71) [3]
MK-2206 + GDC-0084 DCI1WR6 MK-2206 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + GDC-0084 DCBB7UL NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [3]
Ombrabulin + GDC-0084 DCTM69U Ombrabulin Hodgkin lymphoma (Cell Line: HDLM-2) [2]
Ombrabulin + GDC-0084 DCXZ69B Ombrabulin Hodgkin lymphoma (Cell Line: L-428) [2]
Panobinostat + GDC-0084 DC3SCKM Panobinostat Ewing sarcoma (Cell Line: TC-71) [3]
Panobinostat + GDC-0084 DCC2PG8 Panobinostat Hodgkin lymphoma (Cell Line: HDLM-2) [2]
Panobinostat + GDC-0084 DCFWKYR Panobinostat Hodgkin lymphoma (Cell Line: L-428) [2]
Pelitinib + GDC-0084 DCX7EN8 Pelitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
PHA-739358 + GDC-0084 DCP4NIQ PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
PMID25656651-Compound-5 + GDC-0084 DC4WVNG PMID25656651-Compound-5 Hodgkin lymphoma (Cell Line: L-1236) [2]
SNX-5422 + GDC-0084 DCGG28H SNX-5422 Hodgkin lymphoma (Cell Line: HDLM-2) [2]
SNX-5422 + GDC-0084 DCA9E4W SNX-5422 Hodgkin lymphoma (Cell Line: L-428) [2]
TG100801 + GDC-0084 DCCTL5N TG100801 Ewing sarcoma (Cell Line: TC-71) [3]
Vincristine + GDC-0084 DCM2ANZ Vincristine Hodgkin lymphoma (Cell Line: L-1236) [3]
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⏷ Show the Full List of 77 DrugCom(s)

References

1 ClinicalTrials.gov (NCT03522298) Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma. U.S. National Institutes of Health.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.