Details of the Drug Combinations

General Information of This Drug (ID: DMSI5CB)

Drug Name
Chloroquine   DMSI5CB
Synonyms
Amokin; Aralen; Aralen HCl; Arechin; Arechine; Arequin; Arolen; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; CU-01000012392-2; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chlorochinum; Chloroin; Chloroquin; Chloroquina; Chloroquine (USP/INN); Chloroquine (VAN); Chloroquine Bis-Phosphoric Acid; Chloroquine FNA (TN); Chloroquine [USAN:INN:BAN]; Chloroquine phosphate; Chloroquinium; Chloroquinum; Chloroquinum [INN-Latin]; Chlorquin; Cidanchin; Clorochina; Clorochina [DCIT]; Cloroquina; Cloroquina [INN-Spanish]; Cocartrit; Dawaquin (TN); Delagil; Dichinalex; Elestol; Gontochin; Gontochin phosphate; Heliopar; Imagon; Ipsen 225; Iroquine; Khingamin; Klorokin; Lapaquin; Malaquin; Malaquin (*Diphosphate*); Malaren; Malarex; Mesylith; Miniquine; Neochin; Nivachine; Nivaquine B; Pfizerquine; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; RP 3377; RP-3377; Resochen; Resochin; Resochin (TN); Resoquina; Resoquine; Reumachlor; Reumaquin; Rivoquine; Ro 01-6014/N2; Ronaquine; Roquine; SN 6718; SN-7618; ST 21; ST 21 (pharmaceutical); Sanoquin; Silbesan;Siragan; Solprina; Sopaquin; Tanakan; Tanakene; Tresochin; Trochin; W 7618;WIN 244
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Plasmodium falciparum malaria 1F40 Approved [2]
Plasmodium malariae malaria N.A. Approved [2]
Plasmodium ovale malaria N.A. Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [4]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [5]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antimalarials
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

125 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Chloroquine DCFQC96 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
AC265347 + Chloroquine DC1KIZ3 AC265347 DD2 (Cell Line: DD2) [6]
Acamprosate + Chloroquine DCF9X8R Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Acitretin + Chloroquine DCIUAC9 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Alfacalcidol + Chloroquine DC9ET3K Alfacalcidol Hepatoblastoma (Cell Line: HB3) [6]
Alvespimycin hydrochloride + Chloroquine DC0HP0U Alvespimycin hydrochloride Hepatoblastoma (Cell Line: HB3) [7]
Atovaquone + Chloroquine DC9HXI7 Atovaquone Hepatoblastoma (Cell Line: HB3) [6]
Auranofin + Chloroquine DCUKWGC Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Azelnidipine + Chloroquine DCYHMQH Azelnidipine DD2 (Cell Line: DD2) [6]
Bafilomycin A1 + Chloroquine DC3IHOV Bafilomycin A1 DD2 (Cell Line: DD2) [6]
Bafilomycin A1 + Chloroquine DCGVWS4 Bafilomycin A1 Hepatoblastoma (Cell Line: HB3) [7]
Bardoxolone methyl + Chloroquine DCHZU3Z Bardoxolone methyl Primitive neuroectodermal tumor (Cell Line: TC-32) [6]
BIIB-021 + Chloroquine DC49APV BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Biperiden + Chloroquine DC1WW0H Biperiden Hepatoblastoma (Cell Line: HB3) [7]
BIX-01294 + Chloroquine DCGA57W BIX-01294 DD2 (Cell Line: DD2) [6]
Bortezomib + Chloroquine DC29HJY Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
BREQUINAR + Chloroquine DCHG854 BREQUINAR Hepatoblastoma (Cell Line: HB3) [7]
Bumetanide + Chloroquine DCQQHZX Bumetanide DD2 (Cell Line: DD2) [6]
Carfilzomib + Chloroquine DC09ZJ4 Carfilzomib Hepatoblastoma (Cell Line: HB3) [6]
Cerivastatin + Chloroquine DCCYL35 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Sertraline DCY7SBL Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Baclofen DCUIUIU Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Bepridil DCFDZER Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Triiodothyronine DCWVRT5 Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Lumefantrine DCEFL9D Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Kanamycin DC0QXF0 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Artemether DC9GF3T Artemether Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Dihydroergotamine DCEFVES Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Vinblastine DCCWRDG Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + MK-3207 DCHZNV7 MK-3207 Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Fomepizole DC26MJJ Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Everolimus DCLRK6W Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Tetrandrine DCB1Z2O Tetrandrine DD2 (Cell Line: DD2) [6]
Chloroquine + BHV-0223 DC4HJER BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Cantharidin DCDO4VY Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Chloroquine + Metyrosine DCXF20C Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Terameprocol DCOCNFK Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Nicardipine DCFOE6V Nicardipine Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Chlorzoxazone DC93XO8 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Memantine DCGQN8M Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Docetaxel DCI62LE Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Phensuximide DCWM4GX Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Chloroxine DCAWF06 Chloroxine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Chloroquine + Chloroxine DC8WGZF Chloroxine Primitive neuroectodermal tumor (Cell Line: TC-32) [6]
Chloroquine + Fendiline DC0ZGX4 Fendiline Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + PFK-158 DCA5R6I PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Sulfapyridine DCFI3EZ Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Tolvaptan DC2UN2V Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Trifluoperazine DCEYF9P Trifluoperazine DD2 (Cell Line: DD2) [6]
Chloroquine + KN-62 DCR4AZV KN-62 DD2 (Cell Line: DD2) [6]
Chloroquine + Idarubicin DCNQ9IH Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Imatinib DCIW0MI Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Methylene blue DCPCA17 Methylene blue DD2 (Cell Line: DD2) [6]
Chloroquine + Tropisetron DC40UVJ Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Artemisinin DCBPG21 Artemisinin Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Maprotiline DCIPKJG Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Leflunomide DCBRXN0 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Novobiocin DCCEDAS Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Hyodeoxycholic acid DC71058 Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Piperaquine DCNUB4H Piperaquine Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Endoxifen DCFVNMU Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Mycophenolic acid DCQSSPH Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Hydralazine DCNVADH Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + CYTISINE DCSRV77 CYTISINE Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Chloroquine + CYTISINE DCBNQN3 CYTISINE Primitive neuroectodermal tumor (Cell Line: TC-32) [6]
Chloroquine + Lidoflazine DCM91G3 Lidoflazine Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + JTC-801 DCWH7VY JTC-801 DD2 (Cell Line: DD2) [6]
Chloroquine + Vinpocetine DC0TLWD Vinpocetine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Chloroquine + Doxorubicin DC8C4SZ Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Auranofin DC0SY6B Auranofin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Chloroquine + Auranofin DC7B49O Auranofin Primitive neuroectodermal tumor (Cell Line: TC-32) [6]
Chloroquine + Cerivastatin DCZHDXJ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Calindol DCWGEIC Calindol Hepatoblastoma (Cell Line: HB3) [6]
Chloroquine + Aciclovir DCYKV2W Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Chloroquine + Acetohydroxamic Acid DCJ4ZZ0 Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Cilostazol + Chloroquine DC8NL0A Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Clindamycin + Chloroquine DCW1CYV Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Clindamycin + Chloroquine DC1DV29 Clindamycin Hepatoblastoma (Cell Line: HB3) [6]
Clomiphene citrate + Chloroquine DCT52AG Clomiphene citrate DD2 (Cell Line: DD2) [6]
Clomiphene citrate + Chloroquine DCGYFK1 Clomiphene citrate Hepatoblastoma (Cell Line: HB3) [7]
Cycloheximide + Chloroquine DCEKNRB Cycloheximide Hepatoblastoma (Cell Line: HB3) [7]
Cytarabine + Chloroquine DCJGIAM Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Daporinad + Chloroquine DC76RVP Daporinad Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Diphenidol + Chloroquine DCOB1CD Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Eltanexor oral + Chloroquine DCBH4UN Eltanexor oral Hepatoblastoma (Cell Line: HB3) [7]
Fluspirilene + Chloroquine DCOFCRN Fluspirilene DD2 (Cell Line: DD2) [6]
Fluspirilene + Chloroquine DCV1J6E Fluspirilene Hepatoblastoma (Cell Line: HB3) [7]
Gentian violet + Chloroquine DC70XIL Gentian violet Hepatoblastoma (Cell Line: HB3) [7]
Glipizide + Chloroquine DC2TPAT Glipizide Hepatoblastoma (Cell Line: HB3) [7]
GSK2126458 + Chloroquine DC1XHHN GSK2126458 Hepatoblastoma (Cell Line: HB3) [7]
Itraconazole + Chloroquine DCSGB6K Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Levamisole + Chloroquine DCGUHNS Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Lidoflazine + Chloroquine DCU9LSZ Lidoflazine Hepatoblastoma (Cell Line: HB3) [7]
MANOALIDE + Chloroquine DCBW6RU MANOALIDE Hepatoblastoma (Cell Line: HB3) [7]
Mefloquine + Chloroquine DC9UL52 Mefloquine DD2 (Cell Line: DD2) [6]
Methotrexate + Chloroquine DC7K4X4 Methotrexate DD2 (Cell Line: DD2) [6]
MK-3207 + Chloroquine DCPYG6Z MK-3207 Hepatoblastoma (Cell Line: HB3) [7]
Nilotinib + Chloroquine DCKO1QP Nilotinib DD2 (Cell Line: DD2) [6]
Nilotinib + Chloroquine DCM834H Nilotinib Hepatoblastoma (Cell Line: HB3) [7]
Nisoldipine + Chloroquine DCEX7F1 Nisoldipine Hepatoblastoma (Cell Line: HB3) [6]
NITD609 + Chloroquine DCPDP0P NITD609 Hepatoblastoma (Cell Line: HB3) [7]
Nitisinone + Chloroquine DCTJ52D Nitisinone DD2 (Cell Line: DD2) [6]
Nitisinone + Chloroquine DC1ZWIJ Nitisinone Hepatoblastoma (Cell Line: HB3) [6]
Olmesartan medoxomil + Chloroquine DCR3HJU Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Otilonium bromide + Chloroquine DCQW90E Otilonium bromide DD2 (Cell Line: DD2) [6]
Otilonium bromide + Chloroquine DC5V6JP Otilonium bromide Hepatoblastoma (Cell Line: HB3) [6]
Panobinostat + Chloroquine DCBNHXZ Panobinostat Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [6]
Panobinostat + Chloroquine DCQVCLO Panobinostat Hepatoblastoma (Cell Line: HB3) [7]
PD-0173955 + Chloroquine DCBZZIM PD-0173955 Hepatoblastoma (Cell Line: HB3) [7]
Perhexiline + Chloroquine DC1VO1J Perhexiline DD2 (Cell Line: DD2) [6]
Perhexiline + Chloroquine DCYD99P Perhexiline Hepatoblastoma (Cell Line: HB3) [7]
Piperaquine + Chloroquine DCQV5VY Piperaquine DD2 (Cell Line: DD2) [6]
Pyronaridine + Chloroquine DCEKACQ Pyronaridine DD2 (Cell Line: DD2) [6]
Quinine + Chloroquine DCNYA6J Quinine DD2 (Cell Line: DD2) [6]
Relugolix + Chloroquine DC43VPP Relugolix DD2 (Cell Line: DD2) [6]
Remdesivir + Chloroquine DCWP6Z7 Remdesivir Coronavirus Disease 2019 (COVID-19) (Cell Line: .) [8]
RTB101 + Chloroquine DCLC3IB RTB101 Primitive neuroectodermal tumor (Cell Line: TC-32) [6]
Sotalol + Chloroquine DCO13HQ Sotalol Hepatoblastoma (Cell Line: HB3) [7]
Tiagabine + Chloroquine DC4Q9MX Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Tranylcypromine + Chloroquine DCTTOUD Tranylcypromine DD2 (Cell Line: DD2) [6]
Trichostatin A + Chloroquine DC2R3D1 Trichostatin A DD2 (Cell Line: DD2) [6]
Trichostatin A + Chloroquine DCLPZYJ Trichostatin A Hepatoblastoma (Cell Line: HB3) [7]
Vorinostat + Chloroquine DC202LF Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
ZSTK474 + Chloroquine DC7VRXV ZSTK474 DD2 (Cell Line: DD2) [6]
ZSTK474 + Chloroquine DCI4T95 ZSTK474 Hepatoblastoma (Cell Line: HB3) [6]
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⏷ Show the Full List of 125 DrugCom(s)
1 Discontinued Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Azithromycin + Chloroquine DCPBGEO Azithromycin Bacterial infection [9]
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12 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Artesunate + Chloroquine DCNDOA2 Artesunate Uncomplicated Falciparum Malaria [10]
Artesunate + Chloroquine DCPMMUQ Artesunate Plasmodium Falciparum Infection [11]
Azithromycin + Chloroquine DCHVLZW Azithromycin Plasmodium Falciparum Infection [11]
Azithromycin + Chloroquine DCXXX1G Azithromycin Malaria Prophylaxis [12]
Gemcitabine + Chloroquine DCSRX1T Gemcitabine Pancreatic Cancer [13]
Pyrimethamine + Chloroquine DCQ5UUQ Pyrimethamine Malaria [14]
Tafenoquine + Chloroquine DC597WV Tafenoquine Malaria [15]
Temozolomide + Chloroquine DC6REIT Temozolomide Glioblastoma [16]
Temozolomide + Chloroquine DCTXR4Y Temozolomide Glioblastoma Multiforme [17]
Tafenoquine + Chloroquine DCH4DDM Tafenoquine Malaria, Vivax [18]
Tafenoquine + Chloroquine DCUK86Y Tafenoquine Malaria, Vivax [19]
Chloroquine + Hydroxychloroquine DC5QFXT Hydroxychloroquine COVID [20]
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⏷ Show the Full List of 12 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5535).
2 Chloroquine FDA Label
3 ClinicalTrials.gov (NCT04360759) Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19. U.S. National Institutes of Health.
4 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
5 Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
6 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
7 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
8 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019101)
10 ClinicalTrials.gov (NCT00959517) Trial of Artesunate Combination Therapy in Pakistan
11 ClinicalTrials.gov (NCT00379821) Chloroquine Alone or in Combination for Malaria in Children in Malawi
12 ClinicalTrials.gov (NCT01100060) A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects
13 ClinicalTrials.gov (NCT01777477) Adjuvant Effect of Chloroquine on Gemcitabine
14 ClinicalTrials.gov (NCT02511054) Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
15 ClinicalTrials.gov (NCT01205178) G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)
16 ClinicalTrials.gov (NCT04397679) Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma
17 ClinicalTrials.gov (NCT02378532) The Addition of Chloroquine to Chemoradiation for Glioblastoma
18 ClinicalTrials.gov (NCT01376167) Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse
19 ClinicalTrials.gov (NCT02563496) A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria
20 ClinicalTrials.gov (NCT04420247) Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19