Details of the Drug Combinations

General Information of This Drug (ID: DMWSXI4)

• Drug Name: Acetylcysteine (DMWSXI4)
• Synonyms: Acetadone EF; Acetadote ALF; Acetylcysteine, Cumberland Pharmaceuticals

Indication

Amyloidosis; ICD 11: 5D00; Status: Approved [1]; Bronchiectasis; ICD 11: CA24; Status: Approved [1]; Bronchitis; ICD 11: CA20; Status: Approved [1]; Bulimia nervosa; ICD 11: 6B81; Status: Approved [1]; Ischemia-reperfusion injury; ICD 11: DB98.B; Status: Approved [1]; Liver disease; ICD 11: DB90-BD99; Status: Approved [2]; Paracetamol poisoning; ICD 11: N.A.; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetylcysteine + Panobinostat	DCD4LAB	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]

22 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetaminophen + Acetylcysteine	DCNXZ2K	Acetaminophen	CBS Deficiency	[4]
Acetazolamide + Acetylcysteine	DCPK6P9	Acetazolamide	Erythrocytosis	[5]
Acetylcysteine + Famotidine	DCFGZ9K	Famotidine	Covid19	[6]
Citalopram + Acetylcysteine	DCFZF3Y	Citalopram	Major Depressive Disorder	[7]
Cocaine + Acetylcysteine	DC95DTW	Cocaine	Cocaine Abuse	[8]
Dexamethasone + Acetylcysteine	DCGHA0E	Dexamethasone	Hepatocellular Carcinoma	[9]
Ethanol + Acetylcysteine	DCTPJHN	Ethanol	Alcohol Use Disorder	[10]
Fenoldopam + Acetylcysteine	DCQ9E5K	Fenoldopam	Kidney Failure, Acute	[11]
Iodixanol + Acetylcysteine	DCZXNGA	Iodixanol	Radiocontrast-induced Nephropathy	[12]
Ondansetron + Acetylcysteine	DC64DJO	Ondansetron	Overdose	[13]
Prednisolone + Acetylcysteine	DC5VDJ4	Prednisolone	Drug Induced Liver Injury	[14]
Rifaximin + Acetylcysteine	DCGWCSC	Rifaximin	Irritable Bowel Syndrome With Diarrhea	[15]
Salbutamol + Acetylcysteine	DCSZ4QX	Salbutamol	Chronic Obstructive Pulmonary Disease	[16]
Sertraline + Acetylcysteine	DCANQ6J	Sertraline	Major Depressive Disorder	[7]
Sodium bicarbonate + Acetylcysteine	DCXHALK	Sodium bicarbonate	Contrast Induced Nephropathy	[17]
Azacitidine + Acetylcysteine	DCKC44Y	Azacitidine	Thrombocytopenia, Isolated	[18]
Deferiprone + Acetylcysteine	DCDGS04	Deferiprone	Diabetes Mellitus	[19]
Pirfenidone + Acetylcysteine	DCEF05R	Pirfenidone	Idiopathic Pulmonary Fibrosis	[20]
Varenicline + Acetylcysteine	DCMWC39	Varenicline	Nicotine Dependence, Cigarettes	[21]
Acetaminophen + Acetylcysteine	DCDFJIE	Acetaminophen	Common Cold	[22]
Amiodarone + Acetylcysteine	DCFCPVE	Amiodarone	Thoracic Surgery	[23]
Atorvastatin + Acetylcysteine	DCT7W2J	Atorvastatin	Coronary Artery Disease	[24]

References

• [1] Acetylcysteine FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT04015557) Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria
• [5] ClinicalTrials.gov (NCT01187108) Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru
• [6] ClinicalTrials.gov (NCT04545008) Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19
• [7] ClinicalTrials.gov (NCT02269540) A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)
• [8] ClinicalTrials.gov (NCT02141620) n-Acetylcysteine and Cocaine
• [9] ClinicalTrials.gov (NCT06039280) Comparison of Dexamethasone and N Acetylcysteine (NAC) Versus N Acetylcysteine (NAC) Alone in the Prevention of Post Embolization Syndrome in Patients With Hepatocellular Carcinoma Following Transarterial Chemoembolization.
• [10] ClinicalTrials.gov (NCT03216954) Influence of n-Acetylcysteine Maintenance on Alcohol Effects
• [11] ClinicalTrials.gov (NCT00122018) An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
• [12] ClinicalTrials.gov (NCT00558142) Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material
• [13] ClinicalTrials.gov (NCT01050270) Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
• [14] ClinicalTrials.gov (NCT02686385) Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury
• [15] ClinicalTrials.gov (NCT04557215) Efficacy and Safety of Rifaximin With NAC in IBS-D
• [16] ClinicalTrials.gov (NCT02818270) Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation
• [17] ClinicalTrials.gov (NCT00497328) COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
• [18] ClinicalTrials.gov (NCT05126004) AZA Combined With NAC for PIT After HSCT
• [19] ClinicalTrials.gov (NCT02882477) Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
• [20] ClinicalTrials.gov (NCT02707640) A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF)
• [21] ClinicalTrials.gov (NCT02723162) Translational Neuropsychopharmacology Research of Nicotine Addiction
• [22] ClinicalTrials.gov (NCT05070650) Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold
• [23] ClinicalTrials.gov (NCT02750319) Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery
• [24] ClinicalTrials.gov (NCT06139952) Ameliorating Contrast Induced Nephropathy After Coronary Angiography