Details of the Drug Combination

General Information of Drug Combination (ID: DC95DTW)

Drug Combination Name
Cocaine Acetylcysteine
Indication
Disease Entry Status REF
Cocaine Abuse Phase 1 [1]
Component Drugs Cocaine   DMSOX7I Acetylcysteine   DMWSXI4
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cocaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Cocaine addiction 6C45.2 Approved [3]
Cocaine Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [11]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [11]
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Inhibitor [11]
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Cocaine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [13]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [14]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [15]
Butyrylcholine esterase (BCHE) DEIHSMD CHLE_HUMAN Metabolism [16]
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Cocaine Interacts with 261 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Increases Hydrolysis [17]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases ADR [18]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Decreases Expression [6]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Decreases Expression [6]
Septin-4 (SEPTIN4) OTD16B30 SEPT4_HUMAN Decreases Expression [6]
LIM domain-binding protein 2 (LDB2) OT6Y8IEK LDB2_HUMAN Decreases Expression [6]
Phospholipid phosphatase 2 (PLPP2) OT0BQAXX PLPP2_HUMAN Decreases Expression [6]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [6]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Decreases Expression [6]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Decreases Expression [6]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Decreases Expression [6]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [6]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Increases Expression [6]
Cytochrome c1, heme protein, mitochondrial (CYC1) OT0962IM CY1_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS2 (RPSA) OTJZHEGT RSSA_HUMAN Decreases Expression [6]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [6]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Decreases Expression [6]
Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) OTPB1RGK GNAO_HUMAN Decreases Expression [6]
Clathrin light chain B (CLTB) OTPW9VRE CLCB_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Decreases Expression [6]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [6]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Decreases Expression [6]
Neuroendocrine convertase 2 (PCSK2) OT9Y2Z9B NEC2_HUMAN Decreases Expression [6]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Decreases Expression [6]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) OTZA82J1 PTPRA_HUMAN Decreases Expression [6]
Pleiotrophin (PTN) OTYC7M2A PTN_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Expression [6]
Gap junction beta-2 protein (GJB2) OTBKLEYB CXB2_HUMAN Decreases Expression [6]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Decreases Expression [6]
Vesicle-fusing ATPase (NSF) OTKRJ2ZT NSF_HUMAN Decreases Expression [6]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Decreases Expression [6]
F-actin-capping protein subunit beta (CAPZB) OTF1A4N0 CAPZB_HUMAN Decreases Expression [6]
G protein-activated inward rectifier potassium channel 2 (KCNJ6) OTDE1FT0 KCNJ6_HUMAN Decreases Expression [6]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [6]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [6]
Translocon-associated protein subunit delta (SSR4) OTBWBGMR SSRD_HUMAN Decreases Expression [6]
Neuronal membrane glycoprotein M6-a (GPM6A) OT8G13EG GPM6A_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [6]
Ataxin-3 (ATXN3) OTJVVGKT ATX3_HUMAN Decreases Expression [6]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) OT7Y43A1 PP1A_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Decreases Expression [6]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) OTLL7L74 GBB1_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) OT83PT85 PP2AA_HUMAN Decreases Expression [6]
Vacuolar fusion protein CCZ1 homolog B (CCZ1B) OT1TTYK1 CCZ1B_HUMAN Decreases Expression [6]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Decreases Expression [6]
Transcription factor AP-4 (TFAP4) OT1KQIUX TFAP4_HUMAN Increases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Expression [6]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Expression [6]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Increases Expression [6]
Cadherin-17 (CDH17) OT9EV2XK CAD17_HUMAN Decreases Expression [6]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Decreases Expression [6]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Increases Expression [6]
Beta-sarcoglycan (SGCB) OT5R5LAT SGCB_HUMAN Decreases Expression [6]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [6]
Rho GTPase-activating protein 29 (ARHGAP29) OT8JH4TY RHG29_HUMAN Decreases Expression [6]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Decreases Expression [6]
Transgelin-3 (TAGLN3) OTJBP3VJ TAGL3_HUMAN Decreases Expression [6]
Catenin delta-2 (CTNND2) OTYKE30Y CTND2_HUMAN Decreases Expression [6]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Increases Expression [6]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [19]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Expression [19]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Expression [19]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Decreases Expression [19]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Increases Expression [20]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Decreases Expression [20]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Expression [21]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Increases Expression [21]
Integrin beta-1-binding protein 1 (ITGB1BP1) OTVQFNGS ITBP1_HUMAN Increases Expression [9]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) OTEZVTI1 DNPH1_HUMAN Decreases Expression [9]
Oligophrenin-1 (OPHN1) OTDURZAV OPHN1_HUMAN Increases Expression [21]
Liprin-alpha-3 (PPFIA3) OTNPZ6HT LIPA3_HUMAN Increases Expression [22]
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) OTBT8KW9 NDUS2_HUMAN Affects Expression [23]
Pituitary homeobox 3 (PITX3) OTE2KT8P PITX3_HUMAN Decreases Expression [24]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Decreases Expression [9]
Claudin-11 (CLDN11) OTNN6UTL CLD11_HUMAN Decreases Expression [25]
TIP41-like protein (TIPRL) OTS2FZ8O TIPRL_HUMAN Increases Expression [21]
Protocadherin-8 (PCDH8) OTDDOQM2 PCDH8_HUMAN Increases Expression [21]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Affects Expression [23]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Increases Expression [21]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [21]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [21]
Adenylate kinase isoenzyme 1 (AK1) OT614AR3 KAD1_HUMAN Decreases Expression [9]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [26]
Beta-nerve growth factor (NGF) OTOLABJT NGF_HUMAN Decreases Expression [27]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Increases Expression [28]
Pro-opiomelanocortin (POMC) OTV41F7T COLI_HUMAN Increases Secretion [29]
Proenkephalin-A (PENK) OT8P3HMP PENK_HUMAN Decreases Expression [30]
Proenkephalin-B (PDYN) OTEJ6430 PDYN_HUMAN Increases Expression [9]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Increases Secretion [31]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Decreases Expression [32]
Insulin (INS) OTZ85PDU INS_HUMAN Decreases Expression [33]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [34]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [35]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [8]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Decreases Expression [9]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [9]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Increases Expression [36]
Serum amyloid P-component (APCS) OT76JZ8Z SAMP_HUMAN Increases Expression [37]
Platelet basic protein (PPBP) OT1FHGQS CXCL7_HUMAN Increases Expression [38]
Platelet factor 4 (PF4) OTEMJU68 PLF4_HUMAN Increases Expression [38]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Secretion [39]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [9]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Decreases Expression [25]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Expression [9]
Inhibin alpha chain (INHA) OT7HWCO3 INHA_HUMAN Decreases Expression [21]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Increases Expression [40]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [34]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [41]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [30]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Decreases Expression [22]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [21]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Decreases Expression [42]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Secretion [39]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Secretion [39]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Affects Expression [23]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [9]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Decreases Expression [21]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Increases Activity [43]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Secretion [39]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Increases Expression [30]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Decreases Expression [21]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [8]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Decreases Expression [30]
Desmoplakin (DSP) OTB2MOP8 DESP_HUMAN Increases Expression [22]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [21]
P-selectin (SELP) OTWR90PK LYAM3_HUMAN Affects Localization [38]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Affects Expression [30]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [30]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Increases Expression [21]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Secretion [44]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [45]
Parvalbumin alpha (PVALB) OTZW1WVQ PRVA_HUMAN Decreases Expression [22]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Secretion [35]
Nucleoside diphosphate kinase B (NME2) OTCYGLHV NDKB_HUMAN Affects Expression [23]
Receptor-type tyrosine-protein phosphatase beta (PTPRB) OTCQPLGZ PTPRB_HUMAN Decreases Expression [21]
Sodium-dependent noradrenaline transporter (SLC6A2) OTMHQJMP SC6A2_HUMAN Decreases Activity [46]
Nuclear transcription factor Y subunit beta (NFYB) OTXSE7KW NFYB_HUMAN Increases Expression [21]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [47]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Affects Expression [23]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Decreases Expression [9]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [21]
Transketolase (TKT) OTT5KPUB TKT_HUMAN Affects Expression [23]
Peroxiredoxin-5, mitochondrial (PRDX5) OTUEKZ18 PRDX5_HUMAN Affects Expression [23]
Phosphatidylethanolamine-binding protein 1 (PEBP1) OTQ5FEI0 PEBP1_HUMAN Affects Expression [23]
CAP-Gly domain-containing linker protein 1 (CLIP1) OTTGAEJE CLIP1_HUMAN Increases Expression [21]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Decreases Activity [48]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Decreases Expression [22]
Gastrin/cholecystokinin type B receptor (CCKBR) OTQSNXOI GASR_HUMAN Decreases Expression [21]
D(3) dopamine receptor (DRD3) OT0OFFKB DRD3_HUMAN Decreases Expression [49]
Alpha-actinin-2 (ACTN2) OT9FOLD7 ACTN2_HUMAN Increases Expression [9]
Hippocalcin-like protein 1 (HPCAL1) OTOBBFRD HPCL1_HUMAN Decreases Expression [9]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Increases Expression [42]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [50]
Glutamate receptor 2 (GRIA2) OT5N1WB7 GRIA2_HUMAN Increases Expression [51]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases Expression [51]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [52]
Beta-crystallin B2 (CRYBB2) OTL0Z8E6 CRBB2_HUMAN Decreases Expression [9]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [24]
Small ribosomal subunit protein uS4 (RPS9) OTPV69Q0 RS9_HUMAN Decreases Expression [9]
Small ribosomal subunit protein eS10 (RPS10) OTE3VSAH RS10_HUMAN Decreases Expression [9]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Decreases Expression [9]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Increases Expression [53]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [30]
AP-2 complex subunit sigma (AP2S1) OTEV2XGW AP2S1_HUMAN Decreases Expression [9]
Ephrin type-B receptor 4 (EPHB4) OTKLPVXJ EPHB4_HUMAN Decreases Expression [21]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Increases Expression [9]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [52]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [53]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [47]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [8]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Affects Expression [23]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Decreases Expression [9]
Glutamate receptor ionotropic, NMDA 1 (GRIN1) OTZ5YBO8 NMDZ1_HUMAN Increases Expression [51]
Synaptic vesicular amine transporter (SLC18A2) OTUOMMM6 VMAT2_HUMAN Decreases Expression [54]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [8]
Peptidyl-prolyl cis-trans isomerase D (PPID) OT2CDF7W PPID_HUMAN Increases Expression [21]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Expression [42]
Dystrophin-related protein 2 (DRP2) OTWR7WGU DRP2_HUMAN Affects Expression [23]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) OTS9YK3E KCC2B_HUMAN Decreases Expression [42]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [9]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [21]
Myocyte-specific enhancer factor 2D (MEF2D) OT7CEIG0 MEF2D_HUMAN Decreases Expression [21]
Proteasome activator complex subunit 4 (PSME4) OTDGF53O PSME4_HUMAN Increases Expression [9]
Cysteine and glycine-rich protein 2 (CSRP2) OT4SW0HI CSRP2_HUMAN Decreases Expression [21]
Cocaine- and amphetamine-regulated transcript protein (CARTPT) OTTE4V9S CART_HUMAN Increases Expression [9]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Expression [9]
Prolyl endopeptidase-like (PREPL) OTN5XMLZ PPCEL_HUMAN Increases Expression [47]
Myomegalin (PDE4DIP) OTS15WNF MYOME_HUMAN Decreases Expression [47]
Adropin (ENHO) OT91QASK ENHO_HUMAN Decreases Expression [47]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [21]
Tumor protein p53-inducible nuclear protein 2 (TP53INP2) OT0GTBXO T53I2_HUMAN Decreases Expression [9]
RING1 and YY1-binding protein (RYBP) OTZZ4P2Z RYBP_HUMAN Increases Expression [21]
Programmed cell death protein 7 (PDCD7) OTK5YO7J PDCD7_HUMAN Increases Expression [21]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [9]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Increases Expression [42]
Protein Churchill (CHURC1) OTCVNVQN CHUR_HUMAN Decreases Expression [9]
Connector enhancer of kinase suppressor of ras 2 (CNKSR2) OTAGERJ2 CNKR2_HUMAN Increases Expression [9]
Lysophosphatidic acid receptor 1 (LPAR1) OTJNJQPF LPAR1_HUMAN Decreases Expression [9]
Zinc finger protein ubi-d4 (DPF2) OTL0JH2C REQU_HUMAN Increases Expression [21]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [8]
Protein MAL2 (MAL2) OTVPEI80 MAL2_HUMAN Increases Expression [9]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Increases Expression [9]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Increases Expression [21]
GRIP and coiled-coil domain-containing protein 1 (GCC1) OTDOE6U8 GCC1_HUMAN Increases Expression [42]
Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A) OTHQP0L5 FAH2A_HUMAN Affects Expression [23]
Protein arginine N-methyltransferase 6 (PRMT6) OT5V3XIN ANM6_HUMAN Decreases Expression [55]
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) OT1B19RU NED4L_HUMAN Increases Expression [9]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Increases Expression [9]
Sigma non-opioid intracellular receptor 1 (SIGMAR1) OTDORW5C SGMR1_HUMAN Affects Binding [56]
Apolipoprotein L2 (APOL2) OT303Q7B APOL2_HUMAN Increases Expression [42]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Decreases Expression [9]
Synaptotagmin-11 (SYT11) OTLRTZEI SYT11_HUMAN Increases Expression [21]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) OTG0B7RM SCMC3_HUMAN Decreases Expression [47]
Oxysterol-binding protein-related protein 1 (OSBPL1A) OTQ33OQV OSBL1_HUMAN Decreases Expression [9]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [9]
Semaphorin-6A (SEMA6A) OTDQ7QAW SEM6A_HUMAN Decreases Expression [21]
E3 ubiquitin-protein ligase MARCHF7 (MARCHF7) OTG9SF10 MARH7_HUMAN Increases Expression [21]
Serine/threonine-protein kinase PAK 6 (PAK6) OTAHPZTT PAK6_HUMAN Decreases Expression [21]
Beta-catenin-interacting protein 1 (CTNNBIP1) OTX9SBJG CNBP1_HUMAN Decreases Expression [21]
Protein lin-7 homolog C (LIN7C) OTB3015O LIN7C_HUMAN Increases Expression [21]
Mitoferrin-1 (SLC25A37) OTJ9F01S MFRN1_HUMAN Increases Expression [9]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) OT3XMZU3 FLRT3_HUMAN Increases Expression [21]
Sodium/hydrogen exchanger 2 (SLC9A2) OTYZYSHX SL9A2_HUMAN Decreases Expression [21]
Klotho (KL) OTD4VWU6 KLOT_HUMAN Increases Expression [9]
ProSAAS (PCSK1N) OT7ZRW2F PCS1N_HUMAN Decreases Expression [9]
Protein FAM153A (FAM153A) OTNHG4S2 F153A_HUMAN Increases Expression [47]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5) OTY807N5 ENPP5_HUMAN Increases Expression [9]
Probable ATP-dependent RNA helicase DDX41 (DDX41) OT6KEIHP DDX41_HUMAN Decreases Expression [21]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) OTW28QTH HCN2_HUMAN Increases Expression [21]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [9]
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) OTSQTPFQ SHAN2_HUMAN Decreases Expression [21]
Paraplegin (SPG7) OT8OY9ST SPG7_HUMAN Decreases Expression [21]
Solute carrier family 22 member 14 (SLC22A14) OTHRY1XS S22AE_HUMAN Decreases Expression [21]
UDP-N-acetylglucosamine transporter (SLC35A3) OTG92DK5 S35A3_HUMAN Increases Expression [21]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Decreases Expression [9]
Protocadherin gamma-A1 (PCDHGA1) OTR1U1LI PCDG1_HUMAN Increases Expression [21]
Protocadherin alpha-2 (PCDHA2) OTAV93M9 PCDA2_HUMAN Increases Expression [21]
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Increases Response To Substance [57]
Sodium-dependent dopamine transporter (SLC6A3) OT39XG28 SC6A3_HUMAN Increases Response To Substance [58]
Calcium/calmodulin-dependent protein kinase type IV (CAMK4) OT47RDGV KCC4_HUMAN Increases Response To Substance [59]
Collagen alpha-1(XXI) chain (COL21A1) OT7GS82E COLA1_HUMAN Affects Response To Substance [10]
Neuromedin-K receptor (TACR3) OT7Q68XE NK3R_HUMAN Increases Response To Substance [60]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Hydrolysis [61]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Increases Response To Substance [62]
Dopamine beta-hydroxylase (DBH) OTC6I2SP DOPO_HUMAN Increases Response To Substance [63]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Affects Response To Substance [64]
Synaptotagmin-13 (SYT13) OTG94RJ4 SYT13_HUMAN Affects Response To Substance [10]
Dynein axonemal heavy chain 8 (DNAH8) OTGES2OU DYH8_HUMAN Affects Response To Substance [10]
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) OTGIL2YD ACHA5_HUMAN Decreases Response To Substance [65]
Little elongation complex subunit 2 (ICE2) OTJ3BXND ICE2_HUMAN Affects Response To Substance [10]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Decreases Response To Substance [66]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Affects Response To Substance [67]
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) OTQFH2ZD CAC1D_HUMAN Affects Response To Substance [68]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Increases Response To Substance [69]
Kelch-like protein 5 (KLHL5) OTRDVST4 KLHL5_HUMAN Affects Response To Substance [10]
Probable phospholipid-transporting ATPase IIB (ATP9B) OTRTYQOK ATP9B_HUMAN Affects Response To Substance [10]
Glycoprotein endo-alpha-1,2-mannosidase (MANEA) OTV7L8I6 MANEA_HUMAN Affects Response To Substance [10]
Serine-rich coiled-coil domain-containing protein 1 (CCSER1) OTVLD4J3 CCSE1_HUMAN Affects Response To Substance [10]
Homer protein homolog 1 (HOMER1) OTWFD3SI HOME1_HUMAN Increases Response To Substance [70]
Teneurin-3 (TENM3) OTWY13GR TEN3_HUMAN Affects Response To Substance [10]
------------------------------------------------------------------------------------
⏷ Show the Full List of 261 DOT(s)
Indication(s) of Acetylcysteine
Disease Entry ICD 11 Status REF
Amyloidosis 5D00 Approved [4]
Bronchiectasis CA24 Approved [4]
Bronchitis CA20 Approved [4]
Bulimia nervosa 6B81 Approved [4]
Ischemia-reperfusion injury DB98.B Approved [4]
Liver disease DB90-BD99 Approved [5]
Paracetamol poisoning N.A. Approved [4]

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3 Cocaine FDA Label
4 Acetylcysteine FDA Label
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