Details of the Drug Combination

General Information of Drug Combination (ID: DCXHALK)

Drug Combination Name

Sodium bicarbonate Acetylcysteine

Indication

Disease Entry	Status	REF
Contrast Induced Nephropathy	Phase 1	[1]

Component Drugs

Sodium bicarbonate DMMU6BJ

Acetylcysteine DMWSXI4

Small molecular drug

2D MOL

3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Sodium bicarbonate

Disease Entry	ICD 11	Status	REF
Metabolic acidosis	5C73	Approved	[2]

Sodium bicarbonate Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	TTZPWGN	CAC1H_HUMAN	Blocker	[5]
Voltage-gated potassium channel Kv4.3 (KCND3)	TTPLQO0	KCND3_HUMAN	Blocker	[6]
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Sodium bicarbonate Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Sodium-driven chloride bicarbonate exchanger (SLC4A10)	DT7RYVF	S4A10_HUMAN	Substrate	[7]
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	DTWDEIL	S4A4_HUMAN	Substrate	[8]
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)	DTCL4P8	S4A5_HUMAN	Substrate	[9]
Sodium bicarbonate cotransporter 3 (SLC4A7)	DT03V27	S4A7_HUMAN	Substrate	[9]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	DTW40Z7	S4A8_HUMAN	Substrate	[9]
Anion exchange protein 4 (SLC4A9)	DTSQY0W	B3A4_HUMAN	Substrate	[10]
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⏷ Show the Full List of 6 DTP(s)

Sodium bicarbonate Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	OT727K92	S4A4_HUMAN	Increases Transport	[11]
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Indication(s) of Acetylcysteine

Disease Entry	ICD 11	Status	REF
Amyloidosis	5D00	Approved	[3]
Bronchiectasis	CA24	Approved	[3]
Bronchitis	CA20	Approved	[3]
Bulimia nervosa	6B81	Approved	[3]
Ischemia-reperfusion injury	DB98.B	Approved	[3]
Liver disease	DB90-BD99	Approved	[4]
Paracetamol poisoning	N.A.	Approved	[3]

References

1	ClinicalTrials.gov (NCT00497328) COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4507).
3	Acetylcysteine FDA Label
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Acute renal failure. Clin Evid (Online). 2008 Sep 3;2008. pii: 2001.
6	Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila). 2009 Jan;47(1):14-23.
7	Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90.
8	The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8.
9	The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60.
10	A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011.
11	G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F633-41. doi: 10.1152/ajprenal.00015.2008. Epub 2008 Jul 9.