Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3RWXL)

Drug Name
Resveratrol Drug Info
Synonyms
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
Indication
Disease Entry ICD 11 Status REF
Giant cell arteritis 4A44.2 Phase 3 [1]
Rheumatoid arthritis FA20 Phase 3 [1]
Systemic sclerosis 4A42 Phase 3 [1]
Colorectal cancer 2B91.Z Discontinued in Phase 2 [2]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Cross-matching ID
PubChem CID
445154
ChEBI ID
CHEBI:45713
CAS Number
CAS 501-36-0
TTD Drug ID
DM3RWXL
VARIDT Drug ID
DR00287
INTEDE Drug ID
DR1406

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NAD-dependent deacetylase sirtuin-1 (SIRT1) TTUF2HO SIR1_HUMAN Inhibitor [4]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Discontinued in Phase 2 [6]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Discontinued in Phase 2 [6]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Discontinued in Phase 2 [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Phase 3 [8]
NADPH-dependent curcumin reductase (curA) DEZWDKE CURA_ECOLI Phase 3 [9]
Sulfotransferase 1C2 (SULT1C2) DEYMAD4 ST1C2_HUMAN Phase 3 [10]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT SIRT1 6.202 6.863 6.331 6.61
Prostaglandin G/H synthase 1 (COX-1) DTT PTGS1 6.09 7.747 6.04 7.023
Multidrug resistance-associated protein 1 (ABCC1) DTP MRP1 4.838 6.296 5.935 6.146
Breast cancer resistance protein (ABCG2) DTP BCRP 6.732 7.513 6.326 9.277
Multidrug resistance-associated protein 4 (ABCC4) DTP MRP4 4.797 7.054 6.875 5.42
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 10.036 5.779 6.508 6.481
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Giant cell arteritis
ICD Disease Classification 4A44.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT SIRT1 7.82E-01 -0.16 -0.27
Prostaglandin G/H synthase 1 (COX-1) DTT PTGS1 3.77E-01 0.32 0.73
Multidrug resistance-associated protein 1 (ABCC1) DTP MRP1 3.82E-01 1.16E-01 9.50E-01
Breast cancer resistance protein (ABCG2) DTP BCRP 1.85E-01 -1.34E-01 -4.20E-01
Multidrug resistance-associated protein 4 (ABCC4) DTP MRP4 6.77E-01 3.03E-02 1.51E-01
Sulfotransferase 1C2 (SULT1C2) DME SULT1C2 8.34E-01 6.06E-03 3.55E-02
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 5.25E-01 -4.04E-01 -5.29E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018787)
3 Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect Dis. 2017 Feb 13;17(1):144.
4 Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15.
5 Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37.
6 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
7 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
8 Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82.
9 Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
10 Correlation of reactive oxygen species levels with resveratrol sensitivities of anaplastic thyroid cancer cells. Oxid Med Cell Longev. 2018 Jul 10;2018:6235417.