Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT5E36)

Drug Name
BICARBONATE Drug Info
Synonyms
bicarbonate; Hydrogen carbonate; Bicarbonate ion; Carbonate, hydrogen; Hydrogencarbonate; Bicarbonate ions; 71-52-3; UNII-HN1ZRA3Q20; HCO3-; HN1ZRA3Q20; Bicarbonate anion; Hydrocarbonate(1-); Monohydrogen carbonate; Hydrogen carbonate ion; Hydrogen carbonate anion; Carbonate (HCO31-); Bicarbonates; Carbonate ion (HCO31-); Carboxyolate; Acid carbonate; hydrogen-carbonate; HYDROXYFORMATE; hydrogencarbonate(1-); HCO3; Carbonic acid, ion(1-); hydrogentrioxocarbonate(IV); hydrogentrioxocarbonate(1-); AC1L19ZH
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
769
ChEBI ID
CHEBI:17544
CAS Number
CAS 71-52-3
TTD Drug ID
DMT5E36
VARIDT Drug ID
DR00138

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Anion exchange protein 2 (SLC4A2) DTF7GAL B3A2_HUMAN Phase 3 [2]
Sulfate anion transporter 1 (SLC26A1) DTJ785O S26A1_HUMAN Phase 3 [3]
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Phase 3 [4]
Anion exchange protein 3 (SLC4A3) DT4X2AH B3A3_HUMAN Phase 3 [5]
Anion transporter/exchanger protein 9 (SLC26A9) DT0TZPS S26A9_HUMAN Phase 3 [6]
Anion exchange transporter (SLC26A6) DTVGOLN S26A6_HUMAN Phase 3 [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Sulfate anion transporter 1 (SLC26A1) DTP SAT1 4.681 4.466 3.567 4.07
Anion exchange protein 2 (SLC4A2) DTP AE2 5.194 4.95 6.396 4.807
Anion exchange protein 3 (SLC4A3) DTP AE3 1.888 1.485 1.585 1.963
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IX (CA-IX) DTT CA9 6.08E-15 2.8 7.25
Anion exchange transporter (SLC26A6) DTP SLC26A6 1.11E-02 -6.73E-01 -1.42E+00
Anion exchange transporter (SLC26A7) DTP SLC26A7 6.29E-07 -1.19E+00 -3.64E+00
Sulfate anion transporter 1 (SLC26A1) DTP SAT1 3.31E-02 -1.17E-01 -5.43E-01
Anion exchange protein 2 (SLC4A2) DTP AE2 5.40E-05 -5.61E-01 -1.60E+00
Anion exchange protein 3 (SLC4A3) DTP AE3 1.59E-02 -1.03E-01 -2.64E-01
Anion transporter/exchanger protein 9 (SLC26A9) DTP SLC26A9 1.55E-01 -1.44E+00 -1.03E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.
2 HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9.
3 SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703.
4 Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201.
5 The SLC4 family of bicarbonate (HCO??) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82.
6 SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505.
7 Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005 Jul 20;24(14):2499-511.