General Information of Drug (ID: DM17FKL)

Drug Name
PMID25416646-Compound-Figure5-C Drug Info
Cross-matching ID
TTD Drug ID
DM17FKL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GFT-505 DM7ZOAE Non-alcoholic steatohepatitis DB92.1 Phase 3 [2]
MBX-8025 DMNTCV4 Obesity 5B81 Phase 2/3 [3]
T3D-959 DMR3245 Alzheimer disease 8A20 Phase 2 [4]
T3D-959 DMR3245 Alzheimer disease 8A20 Phase 2 [5]
KD3010 DMNFDYE Metabolic disorder 5C50-5D2Z Phase 1 [6]
SAR351034 DM15PG9 Dyslipidemia 5C80-5C81 Phase 1 [7]
CER-002 DMLBKZV Dyslipidemia 5C80-5C81 Phase 1 [8]
GW-501516 DMPL2KM Type-1 diabetes 5A10 Discontinued in Phase 4 [9]
Sodelglitazar DMJ816F Hyperlipidaemia 5C80 Discontinued in Phase 2 [10]
Indeglitazar DMS56UD Type-2 diabetes 5A11 Discontinued in Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [12]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [13]
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [14]
Rosiglitazone XR DMT45MU Type-2 diabetes 5A11 Approved [15]
Thiazolidinedione DMC1NBW Alzheimer disease 8A20 Approved [13]
Glitazone DMDN4A1 N. A. N. A. Phase 4 [16]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [17]
Rivoglitazone DMBY31K Ocular inflammation 9C61.24 Phase 3 [18]
Balaglitazone DMXBHR6 Type-1 diabetes 5A10 Phase 3 [19]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [20]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor delta (PPARD) TT2JWF6 PPARD_HUMAN Agonist [1]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) TTZMAO3 PPARG_HUMAN Agonist [1]

References

1 PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
2 Dual peroxisome proliferator-activated receptor / agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes Care.2013 Oct;36(10):2923-30.
3 ClinicalTrials.gov (NCT00701883) Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol. U. S. National Institute of Health. 2008.
4 Phrma report (2013 Alzheimers disease)
5 T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38.
6 Kalypsys nearing completion of phase Ia study of KD3010 for metabolic disorders. Kalypsys. 2007.
7 Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31.
8 Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010 May; 30(5): 894-899.
9 Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.Arterioscler Thromb Vasc Biol.2012 Sep;32(9):2289-94.
10 Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7.
11 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7.
12 Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602.
13 Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7.
14 Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74.
15 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
16 Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42.
17 Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95.
18 A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes Obes Metab. 2011 Sep;13(9):806-13.
19 Balaglitazone: a second generation peroxisome proliferator-activated receptor (PPAR) gamma () agonist.Mini Rev Med Chem.2012 Feb;12(2):87-97.
20 Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56.