Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM214Q8)

Drug Name
Talbutal Drug Info
Synonyms
Lotusate; Profundol; Talbumalum; Talbutale; Talbutalum; Talbutal [INN]; Talbutale [DCIT]; WIN 5095; Lotusate (TN); Sec-Butyl allylbarbituric acid; Talbutal (INN); Talbutalum [INN-Latin]; 5-(1-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(1-methylpropyl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-Allyl-5-(1-methylpropyl) barbituric acid; 5-Allyl-5-sec-butylbarbituric acid; 5-Isobutyl-5-allylbarbituric acid; 5-butan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Indication
Disease Entry ICD 11 Status REF
Irritability MB24 Approved [1]
Therapeutic Class
Hypnotics and Sedatives
Cross-matching ID
PubChem CID
8275
ChEBI ID
CHEBI:134923
CAS Number
CAS 115-44-6
TTD Drug ID
DM214Q8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [3]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [4]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [2]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [3]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [5]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [2]
Ganaxolone DMXJMKF Epileptic seizures 8A61-8A6Z Approved [4]
Mebutamate DM0KYI4 Anxiety disorder 6B00-6B0Z Approved [2]
Metharbital DM5A38V Epilepsy 8A60-8A68 Approved [2]
Etomidate DMZI3WO Anaesthesia 9A78.6 Approved [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Modulator [2]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009410.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.