Details of the Drug-Related molecule(s) Interaction Atlas

HY-N0040 Drug Info

Ginsenoside C; Ginsenoside Rb2; Ginsenoside-Rb2; (20S)-ginsenoside Rb2; 11021-13-9; 20-[(6-O-a-L-arabinopyranosyl-ss-D-glucopyranosyl)oxy]-12ss-hydroxydammar-24-en-3ss-yl 2-O-ss-D-glucopyranosyl-ss-D-glucopyranoside; CHEBI:77152; CHEMBL449303; EINECS 234-251-4; HY-N0040; N219O0L31C; NSC 308878; UNII-N219O0L31C; beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-

Cross-matching ID

PubChem CID

6917976

ChEBI ID

CHEBI:77152

CAS Number

CAS 11021-13-9

TTD Drug ID

DM349AM

INTEDE Drug ID

DR2140

General Information of Drug (ID: DM349AM)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Beta-glucosidase (bglA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[2]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[2]
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[2]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[2]
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[3] , [2]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[3] , [2]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[1]
CCG-208408	DMCFEUG	N. A.	N. A.	Preclinical	[4]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-glucosidase (bglA)	DEUQTKA	A0A249DCH3_LACRH	Substrate	[1]
Beta-glucosidase (bglA)	DEUO7V8	A0A509DD13_9STRE	Substrate	[2]
Beta-glucosidase (bglA)	DE4LKZ9	A0A3D1ZWL4_9BIFI	Substrate	[2]
Beta-glucosidase (bglA)	DEM6GYO	A0A351PC96_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DERPJZ6	A0A4Q4LS82_BIFAN	Substrate	[1]

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References

1	Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.
2	Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.
3	Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998 Oct;50(10):1155-60.
4	Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.