General Information of Drug (ID: DM3CZVW)

Drug Name
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide Drug Info
Synonyms
n-(2-flouro-benzyl)-4-sulfamoyl-benzamide; N-[(2-fluorophenyl)methyl]-4-sulfamoylbenzamide; n-(2-fluoro-benzyl)-4-sulfamoyl-benzamide; 2-fluoro-SBB; 1g1d; AC1L1HTZ; SCHEMBL678599; BDBM12014; 1g45; AKOS008607291; DB02069; n-(2-fluorobenzyl)-4-sulfamoylbenzamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4290
TTD Drug ID
DM3CZVW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [2]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [3]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [4]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [5]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [6]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [6]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [7]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [8]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
3 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
4 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
5 Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
6 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
7 Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
8 Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
9 Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
10 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.