Details of the Drug

General Information of Drug (ID: DMQWZ0H)

Drug Name
Benzthiazide
Synonyms
Aquapres; Aquasec; Aquatag; Benzothiazide; Benzotiazida; Benzthazide; Benzthiazidum; Benztiazide; Dihydrex; Diucen;Diucene; Edemex; Exna; Exosalt; Fouane; Fovane; Freeuril; HyDrine; Lemazide; Proaqua; Regulon; Urazide; Urese; Benztiazide [DCIT]; P 1393; Pfizer 1393; Aqua-Scrip; Aquatag (TN); Benzotiazida [INN-Spanish]; Benzthiazidum [INN-Latin]; Dihydrex (TN); Diucen (TN); Edemax (TN); Exna (TN); Foven (TN); Hy-drine; Pro-aqua; Rid-ema; S-Aqua; Benzthiazide (JAN/INN); Benzthiazide [USAN:INN:BAN]; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)menthyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide; 3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(((phenylmethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide; 6-chloro-3-{[(phenylmethyl)thio]methyl}-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Indication
Disease Entry ICD 11 Status REF
High blood pressure BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 431.9
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption
The drug is absorbed in the digestive tract []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 7.70938 micromolar/kg/day [2]
Chemical Identifiers
Formula
C15H14ClN3O4S3
IUPAC Name
3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Canonical SMILES
C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
InChI
InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)
InChIKey
NDTSRXAMMQDVSW-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2343
ChEBI ID
CHEBI:3047
CAS Number
91-33-8
DrugBank ID
DB00562
TTD ID
D0L2MX
INTEDE ID
DR2262

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease High blood pressure
ICD Disease Classification BA00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Benzthiazide
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Ethacrynic acid DM60QMR Moderate Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Ethacrynic acid. Essential hypertension [BA00] [4]
Nadolol DMW6GVL Moderate Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Nadolol. Essential hypertension [BA00] [5]
Coadministration of a Drug Treating the Disease Different from Benzthiazide (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Scopolamine DMOM8AL Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Scopolamine. Addictive disorder [6C50-6C5Z] [6]
Dronedarone DMA8FS5 Major Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Dronedarone. Angina pectoris [BA40] [7]
Linezolid DMGFPU2 Moderate Additive hypotensive effects by the combination of Benzthiazide and Linezolid. Bacterial infection [1A00-1C4Z] [8]
Rabeprazole DMMZXIW Moderate Increased risk of hypomagnesemia by the combination of Benzthiazide and Rabeprazole. Bacterial infection [1A00-1C4Z] [9]
Cariprazine DMJYDVK Moderate Additive hypotensive effects by the combination of Benzthiazide and Cariprazine. Bipolar disorder [6A60] [10]
Ketoprofen DMRKXPT Moderate Antagonize the effect of Benzthiazide when combined with Ketoprofen. Chronic pain [MG30] [11]
Levomilnacipran DMV26S8 Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Levomilnacipran. Chronic pain [MG30] [12]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Benzthiazide and Olopatadine. Conjunctiva disorder [9A60] [13]
Sertraline DM0FB1J Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Sertraline. Depression [6A70-6A7Z] [12]
Vilazodone DM4LECQ Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Vilazodone. Depression [6A70-6A7Z] [12]
Paroxetine DM5PVQE Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Paroxetine. Depression [6A70-6A7Z] [12]
Vortioxetine DM6F1PU Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Vortioxetine. Depression [6A70-6A7Z] [12]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Benzthiazide and Isocarboxazid. Depression [6A70-6A7Z] [8]
Milnacipran DMBFE74 Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Milnacipran. Depression [6A70-6A7Z] [12]
Escitalopram DMFK9HG Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Escitalopram. Depression [6A70-6A7Z] [12]
Tranylcypromine DMGB5RE Moderate Additive hypotensive effects by the combination of Benzthiazide and Tranylcypromine. Depression [6A70-6A7Z] [14]
Desvenlafaxine DMHD4PE Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Desvenlafaxine. Depression [6A70-6A7Z] [12]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Benzthiazide and OPC-34712. Depression [6A70-6A7Z] [10]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Benzthiazide and Phenelzine. Depression [6A70-6A7Z] [8]
Mepenzolate DM8YU2F Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Mepenzolate. Digestive system disease [DE2Z] [6]
Oxybutynine DMJPBAX Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Oxybutynine. Discovery agent [N.A.] [6]
Carbamazepine DMZOLBI Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Carbamazepine. Epilepsy/seizure [8A61-8A6Z] [15]
Eslicarbazepine DMZREFQ Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Eslicarbazepine. Epilepsy/seizure [8A61-8A6Z] [16]
Mefenamic acid DMK7HFI Moderate Antagonize the effect of Benzthiazide when combined with Mefenamic acid. Female pelvic pain [GA34] [11]
Solifenacin DMG592Q Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Solifenacin. Functional bladder disorder [GC50] [6]
Tolterodine DMSHPW8 Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Tolterodine. Functional bladder disorder [GC50] [6]
Propantheline DM2EN6G Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Propantheline. Gastric ulcer [DA60] [6]
Dexlansoprazole DM1DBV5 Moderate Increased risk of hypomagnesemia by the combination of Benzthiazide and Dexlansoprazole. Gastro-oesophageal reflux disease [DA22] [9]
Metipranolol DMJMVKI Moderate Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Metipranolol. Glaucoma [9C61] [5]
Levobunolol DMTNFCQ Moderate Increased risk of hyperglycemia by the combination of Benzthiazide and Levobunolol. Glaucoma [9C61] [5]
Carvedilol DMHTEAO Moderate Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Carvedilol. Heart failure [BD10-BD1Z] [5]
Furosemide DMMQ8ZG Moderate Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Furosemide. Heart failure [BD10-BD1Z] [17]
Bumetanide DMRV7H0 Moderate Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Bumetanide. Heart failure [BD10-BD1Z] [17]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Benzthiazide and Procarbazine. Hodgkin lymphoma [2B30] [8]
Acebutolol DM0TI4U Moderate Increased risk of hyperglycemia by the combination of Benzthiazide and Acebutolol. Hypertension [BA00-BA04] [5]
Moexipril DM26E4B Moderate Additive hypotensive effects by the combination of Benzthiazide and Moexipril. Hypertension [BA00-BA04] [18]
Bisoprolol DM3UZ95 Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Bisoprolol. Hypertension [BA00-BA04] [5]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Benzthiazide and Captopril. Hypertension [BA00-BA04] [18]
Nebivolol DM7F1PA Moderate Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Nebivolol. Hypertension [BA00-BA04] [5]
Pindolol DMD2NV7 Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Pindolol. Hypertension [BA00-BA04] [5]
Enalapril DMNFUZR Moderate Additive hypotensive effects by the combination of Benzthiazide and Enalapril. Hypertension [BA00-BA04] [18]
Perindopril DMOPZDT Moderate Additive hypotensive effects by the combination of Benzthiazide and Perindopril. Hypertension [BA00-BA04] [18]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Benzthiazide and Quinapril. Hypertension [BA00-BA04] [18]
Lisinopril DMUOK4C Moderate Additive hypotensive effects by the combination of Benzthiazide and Lisinopril. Hypertension [BA00-BA04] [18]
Belladonna DM2RBWK Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Belladonna. Infectious gastroenteritis/colitis [1A40] [6]
Meclofenamic acid DM05FXR Moderate Antagonize the effect of Benzthiazide when combined with Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [11]
ITI-007 DMUQ1DO Moderate Additive hypotensive effects by the combination of Benzthiazide and ITI-007. Insomnia [7A00-7A0Z] [10]
Clidinium DMUMQZ0 Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Clidinium. Irritable bowel syndrome [DD91] [6]
Dicyclomine DMZSDGX Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Dicyclomine. Irritable bowel syndrome [DD91] [6]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Benzthiazide and Porfimer Sodium. Lung cancer [2C25] [19]
Arsenic trioxide DM61TA4 Major Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Arsenic trioxide. Mature B-cell lymphoma [2A85] [20]
Propranolol DM79NTF Moderate Increased risk of hyperglycemia by the combination of Benzthiazide and Propranolol. Migraine [8A80] [5]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Benzthiazide and Ozanimod. Multiple sclerosis [8A40] [8]
Promethazine DM6I5GR Moderate Additive hypotensive effects by the combination of Benzthiazide and Promethazine. Nausea/vomiting [MD90] [10]
Sibutramine DMFJTDI Moderate Increased risk of hyponatremia by the combination of Benzthiazide and Sibutramine. Obesity [5B80-5B81] [12]
Diclofenac DMPIHLS Moderate Antagonize the effect of Benzthiazide when combined with Diclofenac. Osteoarthritis [FA00-FA05] [11]
Naproxen DMZ5RGV Moderate Antagonize the effect of Benzthiazide when combined with Naproxen. Osteoarthritis [FA00-FA05] [11]
Etodolac DM6WJO9 Moderate Antagonize the effect of Benzthiazide when combined with Etodolac. Pain [MG30-MG3Z] [11]
Diflunisal DM7EN8I Moderate Antagonize the effect of Benzthiazide when combined with Diflunisal. Pain [MG30-MG3Z] [11]
Ibuprofen DM8VCBE Moderate Antagonize the effect of Benzthiazide when combined with Ibuprofen. Pain [MG30-MG3Z] [11]
Flavoxate DMKV4NL Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Flavoxate. Pain [MG30-MG3Z] [6]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Benzthiazide and Safinamide. Parkinsonism [8A00] [8]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Benzthiazide and Rasagiline. Parkinsonism [8A00] [8]
Biperiden DME78OA Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Biperiden. Parkinsonism [8A00] [6]
Methylscopolamine DM5VWOB Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Methylscopolamine. Peptic ulcer [DA61] [6]
Esomeprazole DM7BN0X Moderate Increased risk of hypomagnesemia by the combination of Benzthiazide and Esomeprazole. Peptic ulcer [DA61] [9]
Meloxicam DM2AR7L Moderate Antagonize the effect of Benzthiazide when combined with Meloxicam. Rheumatoid arthritis [FA20] [11]
Sulindac DM2QHZU Moderate Antagonize the effect of Benzthiazide when combined with Sulindac. Rheumatoid arthritis [FA20] [11]
Oxaprozin DM9UB0P Moderate Antagonize the effect of Benzthiazide when combined with Oxaprozin. Rheumatoid arthritis [FA20] [11]
Flurbiprofen DMGN4BY Moderate Antagonize the effect of Benzthiazide when combined with Flurbiprofen. Rheumatoid arthritis [FA20] [11]
Fenoprofen DML5VQ0 Moderate Antagonize the effect of Benzthiazide when combined with Fenoprofen. Rheumatoid arthritis [FA20] [11]
Quetiapine DM1N62C Moderate Additive hypotensive effects by the combination of Benzthiazide and Quetiapine. Schizophrenia [6A20] [10]
Mesoridazine DM2ZGAN Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Mesoridazine. Schizophrenia [6A20] [21]
Thioridazine DM35M8J Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Thioridazine. Schizophrenia [6A20] [21]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Benzthiazide and Aripiprazole. Schizophrenia [6A20] [10]
Iloperidone DM6AUFY Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Iloperidone. Schizophrenia [6A20] [21]
Paliperidone DM7NPJS Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Paliperidone. Schizophrenia [6A20] [21]
Perphenazine DMA4MRX Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Perphenazine. Schizophrenia [6A20] [21]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Benzthiazide and Molindone. Schizophrenia [6A20] [10]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Benzthiazide and Thiothixene. Schizophrenia [6A20] [10]
Trifluoperazine DMKBYWI Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Trifluoperazine. Schizophrenia [6A20] [21]
Risperidone DMN6DXL Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Risperidone. Schizophrenia [6A20] [21]
Amisulpride DMSJVAM Moderate Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Amisulpride. Schizophrenia [6A20] [21]
Asenapine DMSQZE2 Moderate Additive hypotensive effects by the combination of Benzthiazide and Asenapine. Schizophrenia [6A20] [10]
Pimozide DMW83TP Major Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Pimozide. Schizophrenia [6A20] [22]
Atropine DMEN6X7 Minor Altered absorption of Benzthiazide due to GI dynamics variation caused by Atropine. Unspecific substance harmful effect [NE6Z] [6]
Amiodarone DMUTEX3 Major Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Amiodarone. Ventricular tachyarrhythmia [BC71] [23]
⏷ Show the Full List of 87 DDI Information of This Drug

References

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