Details of the Drug

General Information of Drug (ID: DMQWZ0H)

• Drug Name: Benzthiazide
• Synonyms: Aquapres; Aquasec; Aquatag; Benzothiazide; Benzotiazida; Benzthazide; Benzthiazidum; Benztiazide; Dihydrex; Diucen;Diucene; Edemex; Exna; Exosalt; Fouane; Fovane; Freeuril; HyDrine; Lemazide; Proaqua; Regulon; Urazide; Urese; Benztiazide [DCIT]; P 1393; Pfizer 1393; Aqua-Scrip; Aquatag (TN); Benzotiazida [INN-Spanish]; Benzthiazidum [INN-Latin]; Dihydrex (TN); Diucen (TN); Edemax (TN); Exna (TN); Foven (TN); Hy-drine; Pro-aqua; Rid-ema; S-Aqua; Benzthiazide (JAN/INN); Benzthiazide [USAN:INN:BAN]; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)menthyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide; 3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(((phenylmethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide; 6-chloro-3-{[(phenylmethyl)thio]methyl}-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Indication

Disease Entry	ICD 11	Status	REF
High blood pressure	BA00	Approved	[1], [2], [3]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 431.9
  Topological Polar Surface Area (xlogp); 1.7
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 7
• ADMET Property:
  Absorption: The drug is absorbed in the digestive tract [4]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 7.70938 micromolar/kg/day [5]
• Chemical Identifiers:
  Formula: C15H14ClN3O4S3
  IUPAC Name: 3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
  Canonical SMILES: C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
  InChI: InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)
  InChIKey: NDTSRXAMMQDVSW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 2343
  ChEBI ID: CHEBI:3047
  CAS Number: 91-33-8
  DrugBank ID: DB00562
  TTD ID: D0L2MX
  INTEDE ID: DR2262

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[6], [7]

Molecular Expression Atlas of This Drug

• The Studied Disease: High blood pressure
• ICD Disease Classification: BA00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Benzthiazide

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Ethacrynic acid	DM60QMR	Moderate	Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Ethacrynic acid.	Essential hypertension [BA00]	[17]
Nadolol	DMW6GVL	Moderate	Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Nadolol.	Essential hypertension [BA00]	[18]

Coadministration of a Drug Treating the Disease Different from Benzthiazide (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Scopolamine	DMOM8AL	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Scopolamine.	Addictive disorder [6C50-6C5Z]	[19]
Dronedarone	DMA8FS5	Major	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Dronedarone.	Angina pectoris [BA40]	[20]
Linezolid	DMGFPU2	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Linezolid.	Bacterial infection [1A00-1C4Z]	[21]
Rabeprazole	DMMZXIW	Moderate	Increased risk of hypomagnesemia by the combination of Benzthiazide and Rabeprazole.	Bacterial infection [1A00-1C4Z]	[22]
Cariprazine	DMJYDVK	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Cariprazine.	Bipolar disorder [6A60]	[23]
Ketoprofen	DMRKXPT	Moderate	Antagonize the effect of Benzthiazide when combined with Ketoprofen.	Chronic pain [MG30]	[24]
Levomilnacipran	DMV26S8	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Levomilnacipran.	Chronic pain [MG30]	[25]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Benzthiazide and Olopatadine.	Conjunctiva disorder [9A60]	[26]
Sertraline	DM0FB1J	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Sertraline.	Depression [6A70-6A7Z]	[25]
Vilazodone	DM4LECQ	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Vilazodone.	Depression [6A70-6A7Z]	[25]
Paroxetine	DM5PVQE	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Paroxetine.	Depression [6A70-6A7Z]	[25]
Vortioxetine	DM6F1PU	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Vortioxetine.	Depression [6A70-6A7Z]	[25]
Isocarboxazid	DMAF1NB	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Isocarboxazid.	Depression [6A70-6A7Z]	[21]
Milnacipran	DMBFE74	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Milnacipran.	Depression [6A70-6A7Z]	[25]
Escitalopram	DMFK9HG	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Escitalopram.	Depression [6A70-6A7Z]	[25]
Tranylcypromine	DMGB5RE	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Tranylcypromine.	Depression [6A70-6A7Z]	[27]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Desvenlafaxine.	Depression [6A70-6A7Z]	[25]
OPC-34712	DMHG57U	Moderate	Additive hypotensive effects by the combination of Benzthiazide and OPC-34712.	Depression [6A70-6A7Z]	[23]
Phenelzine	DMHIDUE	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Phenelzine.	Depression [6A70-6A7Z]	[21]
Mepenzolate	DM8YU2F	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Mepenzolate.	Digestive system disease [DE2Z]	[19]
Oxybutynine	DMJPBAX	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Oxybutynine.	Discovery agent [N.A.]	[19]
Carbamazepine	DMZOLBI	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Carbamazepine.	Epilepsy/seizure [8A61-8A6Z]	[28]
Eslicarbazepine	DMZREFQ	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Eslicarbazepine.	Epilepsy/seizure [8A61-8A6Z]	[29]
Mefenamic acid	DMK7HFI	Moderate	Antagonize the effect of Benzthiazide when combined with Mefenamic acid.	Female pelvic pain [GA34]	[24]
Solifenacin	DMG592Q	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Solifenacin.	Functional bladder disorder [GC50]	[19]
Tolterodine	DMSHPW8	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Tolterodine.	Functional bladder disorder [GC50]	[19]
Propantheline	DM2EN6G	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Propantheline.	Gastric ulcer [DA60]	[19]
Dexlansoprazole	DM1DBV5	Moderate	Increased risk of hypomagnesemia by the combination of Benzthiazide and Dexlansoprazole.	Gastro-oesophageal reflux disease [DA22]	[22]
Metipranolol	DMJMVKI	Moderate	Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Metipranolol.	Glaucoma [9C61]	[18]
Levobunolol	DMTNFCQ	Moderate	Increased risk of hyperglycemia by the combination of Benzthiazide and Levobunolol.	Glaucoma [9C61]	[18]
Carvedilol	DMHTEAO	Moderate	Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Carvedilol.	Heart failure [BD10-BD1Z]	[18]
Furosemide	DMMQ8ZG	Moderate	Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Furosemide.	Heart failure [BD10-BD1Z]	[30]
Bumetanide	DMRV7H0	Moderate	Increased risk of fluid/electrolyte loss by the combination of Benzthiazide and Bumetanide.	Heart failure [BD10-BD1Z]	[30]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Procarbazine.	Hodgkin lymphoma [2B30]	[21]
Acebutolol	DM0TI4U	Moderate	Increased risk of hyperglycemia by the combination of Benzthiazide and Acebutolol.	Hypertension [BA00-BA04]	[18]
Moexipril	DM26E4B	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Moexipril.	Hypertension [BA00-BA04]	[31]
Bisoprolol	DM3UZ95	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Bisoprolol.	Hypertension [BA00-BA04]	[18]
Captopril	DM458UM	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Captopril.	Hypertension [BA00-BA04]	[31]
Nebivolol	DM7F1PA	Moderate	Increased risk of hypertriglyceridemia by the combination of Benzthiazide and Nebivolol.	Hypertension [BA00-BA04]	[18]
Pindolol	DMD2NV7	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Pindolol.	Hypertension [BA00-BA04]	[18]
Enalapril	DMNFUZR	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Enalapril.	Hypertension [BA00-BA04]	[31]
Perindopril	DMOPZDT	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Perindopril.	Hypertension [BA00-BA04]	[31]
Quinapril	DMR8H31	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Quinapril.	Hypertension [BA00-BA04]	[31]
Lisinopril	DMUOK4C	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Lisinopril.	Hypertension [BA00-BA04]	[31]
Belladonna	DM2RBWK	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Belladonna.	Infectious gastroenteritis/colitis [1A40]	[19]
Meclofenamic acid	DM05FXR	Moderate	Antagonize the effect of Benzthiazide when combined with Meclofenamic acid.	Inflammatory spondyloarthritis [FA92]	[24]
ITI-007	DMUQ1DO	Moderate	Additive hypotensive effects by the combination of Benzthiazide and ITI-007.	Insomnia [7A00-7A0Z]	[23]
Clidinium	DMUMQZ0	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Clidinium.	Irritable bowel syndrome [DD91]	[19]
Dicyclomine	DMZSDGX	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Dicyclomine.	Irritable bowel syndrome [DD91]	[19]
Porfimer Sodium	DM7ZWNY	Moderate	Increased risk of photosensitivity reactions by the combination of Benzthiazide and Porfimer Sodium.	Lung cancer [2C25]	[32]
Arsenic trioxide	DM61TA4	Major	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Arsenic trioxide.	Mature B-cell lymphoma [2A85]	[33]
Propranolol	DM79NTF	Moderate	Increased risk of hyperglycemia by the combination of Benzthiazide and Propranolol.	Migraine [8A80]	[18]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Ozanimod.	Multiple sclerosis [8A40]	[21]
Promethazine	DM6I5GR	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Promethazine.	Nausea/vomiting [MD90]	[23]
Sibutramine	DMFJTDI	Moderate	Increased risk of hyponatremia by the combination of Benzthiazide and Sibutramine.	Obesity [5B80-5B81]	[25]
Diclofenac	DMPIHLS	Moderate	Antagonize the effect of Benzthiazide when combined with Diclofenac.	Osteoarthritis [FA00-FA05]	[24]
Naproxen	DMZ5RGV	Moderate	Antagonize the effect of Benzthiazide when combined with Naproxen.	Osteoarthritis [FA00-FA05]	[24]
Etodolac	DM6WJO9	Moderate	Antagonize the effect of Benzthiazide when combined with Etodolac.	Pain [MG30-MG3Z]	[24]
Diflunisal	DM7EN8I	Moderate	Antagonize the effect of Benzthiazide when combined with Diflunisal.	Pain [MG30-MG3Z]	[24]
Ibuprofen	DM8VCBE	Moderate	Antagonize the effect of Benzthiazide when combined with Ibuprofen.	Pain [MG30-MG3Z]	[24]
Flavoxate	DMKV4NL	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Flavoxate.	Pain [MG30-MG3Z]	[19]
Safinamide	DM0YWJC	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Safinamide.	Parkinsonism [8A00]	[21]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Rasagiline.	Parkinsonism [8A00]	[21]
Biperiden	DME78OA	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Biperiden.	Parkinsonism [8A00]	[19]
Methylscopolamine	DM5VWOB	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Methylscopolamine.	Peptic ulcer [DA61]	[19]
Esomeprazole	DM7BN0X	Moderate	Increased risk of hypomagnesemia by the combination of Benzthiazide and Esomeprazole.	Peptic ulcer [DA61]	[22]
Meloxicam	DM2AR7L	Moderate	Antagonize the effect of Benzthiazide when combined with Meloxicam.	Rheumatoid arthritis [FA20]	[24]
Sulindac	DM2QHZU	Moderate	Antagonize the effect of Benzthiazide when combined with Sulindac.	Rheumatoid arthritis [FA20]	[24]
Oxaprozin	DM9UB0P	Moderate	Antagonize the effect of Benzthiazide when combined with Oxaprozin.	Rheumatoid arthritis [FA20]	[24]
Flurbiprofen	DMGN4BY	Moderate	Antagonize the effect of Benzthiazide when combined with Flurbiprofen.	Rheumatoid arthritis [FA20]	[24]
Fenoprofen	DML5VQ0	Moderate	Antagonize the effect of Benzthiazide when combined with Fenoprofen.	Rheumatoid arthritis [FA20]	[24]
Quetiapine	DM1N62C	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Quetiapine.	Schizophrenia [6A20]	[23]
Mesoridazine	DM2ZGAN	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Mesoridazine.	Schizophrenia [6A20]	[34]
Thioridazine	DM35M8J	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Thioridazine.	Schizophrenia [6A20]	[34]
Aripiprazole	DM3NUMH	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Aripiprazole.	Schizophrenia [6A20]	[23]
Iloperidone	DM6AUFY	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Iloperidone.	Schizophrenia [6A20]	[34]
Paliperidone	DM7NPJS	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Paliperidone.	Schizophrenia [6A20]	[34]
Perphenazine	DMA4MRX	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Perphenazine.	Schizophrenia [6A20]	[34]
Molindone	DMAH70G	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Molindone.	Schizophrenia [6A20]	[23]
Thiothixene	DMDINC4	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Thiothixene.	Schizophrenia [6A20]	[23]
Trifluoperazine	DMKBYWI	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Trifluoperazine.	Schizophrenia [6A20]	[34]
Risperidone	DMN6DXL	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Risperidone.	Schizophrenia [6A20]	[34]
Amisulpride	DMSJVAM	Moderate	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Amisulpride.	Schizophrenia [6A20]	[34]
Asenapine	DMSQZE2	Moderate	Additive hypotensive effects by the combination of Benzthiazide and Asenapine.	Schizophrenia [6A20]	[23]
Pimozide	DMW83TP	Major	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Pimozide.	Schizophrenia [6A20]	[35]
Atropine	DMEN6X7	Minor	Altered absorption of Benzthiazide due to GI dynamics variation caused by Atropine.	Unspecific substance harmful effect [NE6Z]	[19]
Amiodarone	DMUTEX3	Major	Increased risk of ventricular arrhythmias by the combination of Benzthiazide and Amiodarone.	Ventricular tachyarrhythmia [BC71]	[36]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7125).
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083206.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] FDA approval: ado-trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer. Clin Cancer Res. 2014 Sep 1;20(17):4436-41.
• [5] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [6] Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
• [7] Diuretic activity of a dihydro-analog of benzthiazide; (3-benzylthiomethyl-6-chloro-7-sulfamyl-3,4 dihydro-1,2,4 benzothiadiazine, 1,1-dioxide). Chemotherapia (Basel). 1962;4:405-12.
• [8] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [9] Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
• [10] Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
• [11] Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
• [12] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [13] Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
• [14] Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
• [15] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
• [16] Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
• [17] Marone C, Muggli F, Lahn W, Frey FJ "Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man." Eur J Clin Invest 15 (1985): 253-7. [PMID: 3935455]
• [18] Dean S, Kendall MJ, Potter S, Thompson MH, Jackson DA "Nadolol in combination with indapamide and xipamide in resistant hypertensives." Eur J Clin Pharmacol 28 (1985): 29-33. [PMID: 3987783]
• [19] Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
• [20] Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
• [21] Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
• [22] FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
• [23] Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
• [24] Muller FO, Schall R, Devaal AC, Groenewoud G, Hundt HKL, Middle MV "Influence of meloxicam on furosemide pharmacokinetics and pharmacodynamics in healthy volunteers." Eur J Clin Pharmacol 48 (1995): 247-51. [PMID: 7589049]
• [25] Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
• [26] Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
• [27] Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
• [28] Yassa R, Nastase C, Camille Y, Henderson M, Belzile L, Beland F "Carbamazepine, diuretics, and hyponatremia: a possible interaction." J Clin Psychiatry 48 (1987): 281-3. [PMID: 3597330]
• [29] Product Information. Aptiom (eslicarbazepine). Sunovion Pharmaceuticals Inc, Marlborough, MA.
• [30] Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61. [PMID: 6701709]
• [31] Burnakis TG, Mioduch HJ "Combined therapy with captopril and potassium supplementation: a potential for hyperkalemia." Arch Intern Med 144 (1984): 2371-2. [PMID: 6391404]
• [32] Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
• [33] Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
• [34] Cerner Multum, Inc. "Australian Product Information.".
• [35] Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
• [36] Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]