Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3ICYL)

Drug Name

AP-301-IH Drug Info

Synonyms

AP-301; AP-301-IRI; AP-301-PN; AP-301-PN); Peptide TNF alpha analog (pneumonia), Apeptico; Peptide TNF alpha modulator (edema in acute lung injury), Apeptico/Medical College of Georgia; Peptide TNF alpha modulator (ischemia/reperfusion injury), Apeptico

Indication

Disease Entry	ICD 11	Status	REF
Pneumonia	CA40	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DM3ICYL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[3]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[4]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[5]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[6]
Enbrel	DM7RNP3	Arthritis	FA20	Approved	[7]
Golimumab	DMHZV7X	Psoriatic arthritis	FA21	Approved	[8]
Certolizumab	DM5CL9Z	Rheumatoid arthritis	FA20	Approved	[9]
Etanercept	DMCV109	Arthritis	FA20	Approved	[10]
Adalimumab	DMQMV1B	Crohn disease	DD70	Approved	[11]
Infliximab	DMH7OIA	Crohn disease	DD70	Approved	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT02095626) Study in Intensive Care Patients Regarding the Effect of Inhaled AP-301 After Primary Graft Dysfunction After Lung Transplantation. U.S. National Institutes of Health.
2	AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na(+) current in primary dog, pig and rat alveolar type II cells. Pulm Pharmacol Ther. 2013 Jun;26(3):356-63.
3	Efficacy of different thalidomide regimens for patients with multiple myeloma and its relationship with TNF-alpha level. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1312-5.
4	Clinical pipeline report, company report or official report of AstraZeneca (2009).
5	Targeted therapies in myelodysplastic syndromes: ASH 2003 review. Semin Hematol. 2004 Apr;41(2 Suppl 4):13-20.
6	Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351.
7	Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loose... J Bone Joint Surg Am. 2001 Jul;83(7):1057-61.
8	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
9	Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
10	The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
11	Adalimumab for psoriasis patients who are non-responders to etanercept: open-label prospective evaluation. J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1394-7.
12	Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):300-9.