Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GIWZ)

Drug Name

Mirogabalin Drug Info

Synonyms

Mirogabalin; 1138245-13-2; UNII-S7LK2KDM5U; DS-5565; S7LK2KDM5U; Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-; Bicyclo(3.2.0)hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-; 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid; ((1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo(3.2.0)hept-3-en-6-yl)acetic acid; Mirogabalin [INN]; Mirogabalin [USAN:INN]; [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid; DS5565; DS 5565; GTPL8303

Indication

Disease Entry	ICD 11	Status	REF
Peripheral neuropathy	8C0Z	Registered	[1]
Cancer related pain	MG30	Phase 3	[2]
Cardiovascular disease	BA00-BE2Z	Phase 3	[3]
Fibromyalgia	MG30.01	Phase 3	[2]

Cross-matching ID

PubChem CID: 59509752
CAS Number: CAS 1138245-13-2
TTD Drug ID: DM5GIWZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[5]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[6]
Lercanidipine	DMPWSEM	Hypertension	BA00-BA04	Approved	[7]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[9]
Imagabalin	DMRLVUD	Generalized anxiety disorder	6B00	Phase 3	[10]
NP-118809	DM8A64W	Pain	MG30-MG3Z	Discontinued in Phase 2	[11]
PD-144550	DM03526	Discovery agent	N.A.	Investigative	[12]
3-Aminomethyl-5-methyl-hexanoic acid	DMTYXH1	Discovery agent	N.A.	Investigative	[12]
(S)-2-amino-3-cyclohexylpropanoic acid	DM1GBX8	Discovery agent	N.A.	Investigative	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Modulator	[4]

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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8303).
4	Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec;37(12):3253-61.
5	Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24.
6	Sulfobutyl ether-alkyl ether mixed cyclodextrin derivatives with enhanced inclusion ability. J Pharm Sci. 2009 Dec;98(12):4769-80.
7	Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):981-7.
8	Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76.
9	A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge. Rev Med Liege. 2007 Nov;62(11):688-94.
10	Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology. Brain Res. 2011 Jul 15;1401:1-9.
11	Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72.
12	Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994).
13	Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.