Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5WZ0O)

Drug Name

EDP-420 Drug Info

Synonyms

EP-013420

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial 23S ribosomal RNA (Bact 23S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[3]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[4]
Thiamphenicol	DMDRKH2	Bacterial infection	1A00-1C4Z	Approved	[5]
Lefamulin	DME6G97	Community-acquired pneumonia	CA40.Z	Approved	[6]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[7]
Spiramycin	DM20R5F	Bacterial infection	1A00-1C4Z	Approved	[8]
Macrolides	DM3BS97	Bacterial infection	1A00-1C4Z	Approved	[9]
Cethromycin	DMIGX84	Bacterial infection	1A00-1C4Z	Phase 3	[10]
Oxazolidinones	DMBM47Z	Gram-positive bacterial infection	1B74-1G40	Phase 2	[11]
Micrococcin	DMJ4D1P	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 23S ribosomal RNA (Bact 23S rRNA)	TTLFGBV	NOUNIPROTAC	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00270517) Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia. U.S. National Institutes of Health.
2	EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May; 51(5): 1666-1670.
3	Company report (JMI Laboratories)
4	Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94.
5	The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
7	Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23.
8	The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
9	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
10	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
11	Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.