General Information of Drug (ID: DM7ZOAE)

Drug Name
GFT-505 Drug Info
Synonyms GFT-1007; PPAR activator (dyslipidemia/type 2 diabetes), Genfit
Indication
Disease Entry ICD 11 Status REF
Non-alcoholic steatohepatitis DB92.1 Phase 3 [1]
Type-2 diabetes 5A11 Phase 2 [2]
Cross-matching ID
PubChem CID
9864881
CAS Number
CAS 923978-27-2
TTD Drug ID
DM7ZOAE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MBX-8025 DMNTCV4 Obesity 5B81 Phase 2/3 [4]
T3D-959 DMR3245 Alzheimer disease 8A20 Phase 2 [5]
T3D-959 DMR3245 Alzheimer disease 8A20 Phase 2 [6]
KD3010 DMNFDYE Metabolic disorder 5C50-5D2Z Phase 1 [7]
SAR351034 DM15PG9 Dyslipidemia 5C80-5C81 Phase 1 [8]
CER-002 DMLBKZV Dyslipidemia 5C80-5C81 Phase 1 [9]
PMID25416646-Compound-Figure5-C DM17FKL N. A. N. A. Patented [10]
GW-501516 DMPL2KM Type-1 diabetes 5A10 Discontinued in Phase 4 [11]
Sodelglitazar DMJ816F Hyperlipidaemia 5C80 Discontinued in Phase 2 [12]
Indeglitazar DMS56UD Type-2 diabetes 5A11 Discontinued in Phase 2 [13]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [14]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [15]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [16]
Ciprofibrate DMGC5DB Hyperlipoproteinemia 5C80 Approved [15]
Pemafibrate DMD1VZL Hyperlipidemia 5C80.Z Approved [17]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [18]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [19]
CS-038 DM67P0F Type-2 diabetes 5A11 Phase 3 [20]
TESAGLITAZAR DMGRBN5 Type-1 diabetes 5A10 Phase 3 [21]
ZYH-1 DMMBJYC Lipid metabolism disorder 5C52.Z Phase 3 [22]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor alpha (PPARA) TTJ584C PPARA_HUMAN Modulator [3]
Peroxisome proliferator-activated receptor delta (PPARD) TT2JWF6 PPARD_HUMAN Modulator [3]

References

1 ClinicalTrials.gov (NCT02704403) Phase 3 Study to Evaluate the Efficacy and Safety of Elafibranor Versus Placebo in Patients With Nonalcoholic Steatohepatitis (NASH) (RESOLVE-IT). U.S. National Institutes of Health.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025107)
3 Dual peroxisome proliferator-activated receptor / agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes Care.2013 Oct;36(10):2923-30.
4 ClinicalTrials.gov (NCT00701883) Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol. U. S. National Institute of Health. 2008.
5 Phrma report (2013 Alzheimers disease)
6 T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38.
7 Kalypsys nearing completion of phase Ia study of KD3010 for metabolic disorders. Kalypsys. 2007.
8 Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31.
9 Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010 May; 30(5): 894-899.
10 PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
11 Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.Arterioscler Thromb Vasc Biol.2012 Sep;32(9):2289-94.
12 Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7.
13 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7.
14 Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74.
15 Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42.
16 Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in... Mol Pharmacol. 2009 Apr;75(4):782-92.
17 Pemafibrate: First Global Approval. Drugs. 2017 Oct;77(16):1805-1810.
18 Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95.
19 Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56.
20 Determination of chiglitazar, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatograph... Pharmazie. 2007 Nov;62(11):825-9.
21 Tesaglitazar, a dual PPAR-/ agonist, hamster carcinogenicity, investigative animal and clinical studies.Toxicol Pathol.2012;40(1):18-32.
22 Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16.