General Information of Drug (ID: DM8Q267)

Drug Name
7-phenethoxy-2H-chromen-2-one Drug Info
Synonyms CHEMBL567544; 7-phenethoxy-2H-chromen-2-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
45485279
TTD Drug ID
DM8Q267

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [2]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [3]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [5]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [6]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [5]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [5]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [1]
CATECHIN DMY38SB Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [7]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [8]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [5]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [6]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [5]
SPERMINE DMD4BFY N. A. N. A. Terminated [8]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [5]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase (CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [10]
Quinethazone DMWCOSR Hypertension BA00-BA04 Approved [11]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [5]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [6]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [12]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [5]
PMID30074415-Compound-21 DM3NPOU N. A. N. A. Patented [13]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [5]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [6]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [14]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [15]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [16]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [1]
Carbonic anhydrase XIV (CA-XIV) TTEYTKG CAH14_HUMAN Inhibitor [1]

References

1 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
2 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
3 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
4 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
5 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
6 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
7 Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.
8 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
9 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
10 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
11 Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for th... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73.
12 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
13 Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.
14 Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-assoc... Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.
15 Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407.
16 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.
17 Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9.
18 Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int J Mol Sci. 2013 May 29;14(6):11402-23.