Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB7WYM)

• Drug Name: ATOSIBAN Drug Info
• Synonyms: Atosiban; Tractocile; 90779-69-4; Atosiban acetate; Antocin; UNII-081D12SI0Z; Rwj 22164; Orf-22164; RWJ-22164; CHEMBL382301; 1-Deamino-2D-tyr-(OEt)-4-thr-8-orn-oxytocin; dTVT; 081D12SI0Z; 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin; 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin; NCGC00165718-01; Atosibanum [INN-Latin]; ORF 22164; deTVT; Atosibanum; Antocin II; Atosiban [USAN:INN:BAN]; RWJ22164; 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-threonine-8-L-ornithineox
• Cross-matching ID:
  PubChem CID: 5311010
  ChEBI ID: CHEBI:135899
  CAS Number: CAS 90779-69-4
  TTD Drug ID: DMB7WYM

Molecule-Related Drug Atlas

Drug(s) Targeting Vasopressin V1b receptor (V1BR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[4]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[5]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[6]
ABT-436	DMNAU1V	Anxiety disorder	6B00-6B0Z	Phase 2	[7]
ARGENINE VASOPRESSIN	DM8KN0Q	Discovery agent	N.A.	Investigative	[8]
D[Arg4,Orn8]VP	DM8D4QT	Discovery agent	N.A.	Investigative	[8]
D[Leu4,Lys8]VP	DMDBU7Q	Discovery agent	N.A.	Investigative	[8]
D[Arg4,Lys8]VP	DM69OVM	Discovery agent	N.A.	Investigative	[8]
D[Cha4,Lys8]VP	DM0GO7U	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Vasopressin V2 receptor (V2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[9]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[10]
Tolvaptan	DMIWFRL	Autosomal dominant polycystic kidney disease	GB81	Approved	[11]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[12]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[13]
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[14]
Satavaptan	DME5PN3	Acute and chronic heart failure	BD1Z	Phase 3	[15]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]
ASP-7035	DMTF24A	Nocturia	MF55	Phase 2	[17]

Drug(s) Targeting Vasopressin V1a receptor (V1AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[18]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[19]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[12]
Felypressin	DMHLP9C	Localisation	N.A.	Approved	[20]
Terlipressin	DMT9FH3	Hypertension	BA00-BA04	Approved	[21]
Balovaptan	DMKMTDG	Autism spectrum disorder	6A02	Phase 3	[22]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[23]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]
VA-111913	DMAYWXD	Dysmenorrhea	GA34.3	Phase 2	[24]

Drug(s) Targeting Oxytocin receptor (OTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[25]
Carbetocin	DMUSLW3	Postpartum haemorrhage	JA43	Approved	[20]
Retosiban	DMOYGZF	Preterm labour	JB00	Phase 3	[26]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]
Barusiban	DMWI0X3	Androgen deficiency	5A81.1	Phase 2	[27]
FE-202767	DMDGZ1C	Erectile dysfunction	HA01.1	Phase 2	[25]
GSK-557296	DM3ZL2O	Premature ejaculation	HA03.0Z	Phase 2	[28]
Pyrrolidine derivative 13	DM3VA8P	N. A.	N. A.	Patented	[29]
PMID28906174-Compound-figure1g	DMECU90	N. A.	N. A.	Patented	[29]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxytocin receptor (OTR)	TTSCIUP	OXYR_HUMAN	Inhibitor	[1]
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Inhibitor	[2]
Vasopressin V1b receptor (V1BR)	TTL9MHW	V1BR_HUMAN	Inhibitor	[2]
Vasopressin V2 receptor (V2R)	TTK8R02	V2R_HUMAN	Inhibitor	[2]

References

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• [2] The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4.
• [3] Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88.
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• [9] Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 368).
• [11] Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 2009 May 1;419(3):577-84.
• [12] Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation. 2001 Nov 13;104(20):2417-23.
• [13] Vasopressin receptors: structure/function relationships and signal transduction in target cells. J Soc Biol. 2005;199(4):351-9.
• [14] Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95.
• [15] Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17.
• [16] Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22.
• [17] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030285)
• [18] Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65.
• [19] Mapping peptide-binding domains of the human V1a vasopressin receptor with a photoactivatable linear peptide antagonist. J Biol Chem. 1997 Oct 17;272(42):26536-44.
• [20] Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512.
• [21] Investigational vasopressin receptor modulators in the pipeline. Expert Opin Investig Drugs. 2009 Aug;18(8):1119-31.
• [22] Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder. J Med Chem. 2020 Feb 27;63(4):1511-1525.
• [23] Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
• [24] Clinical pipeline report, company report or official report of Avarx.
• [25] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369).
• [26] The Effect of an Oxytocin Receptor Antagonist (Retosiban, GSK221149A) on the Response of Human Myometrial Explants to Prolonged Mechanical Stretch.Endocrinology.2015 Oct;156(10):3511-6.
• [27] The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2009 Jun;200(6):627.e1-10.
• [28] Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: a multi-level site of action. Br J Pharmacol. 2013 Aug;169(7):1477-85.
• [29] A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290.